Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Presence of Atopy Increases the Risk of Asthma Relapse

Laurel Teoh, View ORCID ProfileIan Mackay, Peter P Van Asperen, View ORCID ProfileJason Acworth, Mark Hurwitz, View ORCID ProfileJohn W Upham, Weng Hou Siew, Claire YT Wang, View ORCID ProfileTheo P Sloots, View ORCID ProfileTeresa Neeman, View ORCID ProfileAnne B Chang
doi: https://doi.org/10.1101/217547
Laurel Teoh
1Department of Paediatrics and Child Health, Centenary Hospital for Women and Children, Woden, ACT, Australia
2Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ian Mackay
3Queensland Paediatric Infectious Diseases Laboratory
4Child Health Research Centre, The University of Queensland, Brisbane, Qld, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Ian Mackay
Peter P Van Asperen
5Department of Respiratory Medicine, The Children's Hospital at Westmead, Sydney Children's Hospitals Network, Westmead, NSW, Australia
6Discipline of Paediatrics and Child Health, Sydney Medical School, University of Sydney, Sydney, NSW, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jason Acworth
7Emergency Medicine Department, Lady Cilento Children’s Hospital, Brisbane, Qld, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Jason Acworth
Mark Hurwitz
8Department of Respiratory and Sleep Medicine, The Canberra Hospital, Woden, ACT, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
John W Upham
9School of Medicine, The University of Queensland, Brisbane, Qld, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for John W Upham
Weng Hou Siew
3Queensland Paediatric Infectious Diseases Laboratory
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Claire YT Wang
3Queensland Paediatric Infectious Diseases Laboratory
4Child Health Research Centre, The University of Queensland, Brisbane, Qld, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Theo P Sloots
3Queensland Paediatric Infectious Diseases Laboratory
4Child Health Research Centre, The University of Queensland, Brisbane, Qld, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Theo P Sloots
Teresa Neeman
10Statistical Consulting Unit, Australian National University, Canberra, ACT, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Teresa Neeman
Anne B Chang
2Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia
4Child Health Research Centre, The University of Queensland, Brisbane, Qld, Australia
11Respiratory and Sleep Medicine Department, Lady Cilento Children’s Hospital, Brisbane, Qld, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Anne B Chang
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

Objectives In children with hospitalised and non-hospitalised asthma exacerbations, to: (a) describe the point prevalence of respiratory viruses/atypical bacteria using polymerase chain reaction (PCR) and; (b) evaluate the impact of respiratory viruses/atypical bacteria and atopy on acute severity and clinical recovery.

Design This was a prospective study performed during 2009-2011.

Setting The study was performed in the Emergency Departments of 2 hospitals.

Patients 244 children aged 2-16 years presenting with acute asthma to the Emergency Departments were recruited. A nasopharyngeal aspirate and allergen skin prick test were performed.

Main outcome measures The outcomes were divided into (a) acute severity outcomes [Australian National Asthma Council assessment, hospitalisation, Functional Severity Scale, acute asthma score, asthma quality of life questionnaires for parents (PACQLQ) on presentation, asthma diary scores (ADS) on presentation and length of hospitalisation] and (b) recovery outcomes (PACQLQ for 21 days, ADS for 14 days and representation for asthma for 21 days).

Results PCR for viruses/atypical bacteria was positive in 81.7% of children (75.1% human rhinovirus, co-detection in 14.2%). M. pneumoniae and C. pneumoniae were rarely detected. The presence of micro-organisms had little impact on acute asthma or recovery outcomes. Children with atopy were significantly more likely to relapse and represent for medical care by day-14 (OR 1.11, 95%CI 1.00,1.23).

Conclusions The presence of any viruses is associated with asthma exacerbations but does not appear to influence asthma recovery. In contrast, atopy is associated with asthma relapse. M. pneumoniae and C. pneumoniae are rare triggers of acute asthma in young children.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
Back to top
PreviousNext
Posted November 10, 2017.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Presence of Atopy Increases the Risk of Asthma Relapse
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Presence of Atopy Increases the Risk of Asthma Relapse
Laurel Teoh, Ian Mackay, Peter P Van Asperen, Jason Acworth, Mark Hurwitz, John W Upham, Weng Hou Siew, Claire YT Wang, Theo P Sloots, Teresa Neeman, Anne B Chang
bioRxiv 217547; doi: https://doi.org/10.1101/217547
Reddit logo Twitter logo Facebook logo LinkedIn logo Mendeley logo
Citation Tools
Presence of Atopy Increases the Risk of Asthma Relapse
Laurel Teoh, Ian Mackay, Peter P Van Asperen, Jason Acworth, Mark Hurwitz, John W Upham, Weng Hou Siew, Claire YT Wang, Theo P Sloots, Teresa Neeman, Anne B Chang
bioRxiv 217547; doi: https://doi.org/10.1101/217547

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Physiology
Subject Areas
All Articles
  • Animal Behavior and Cognition (4239)
  • Biochemistry (9164)
  • Bioengineering (6801)
  • Bioinformatics (24061)
  • Biophysics (12154)
  • Cancer Biology (9564)
  • Cell Biology (13822)
  • Clinical Trials (138)
  • Developmental Biology (7655)
  • Ecology (11736)
  • Epidemiology (2066)
  • Evolutionary Biology (15538)
  • Genetics (10670)
  • Genomics (14357)
  • Immunology (9508)
  • Microbiology (22894)
  • Molecular Biology (9123)
  • Neuroscience (49107)
  • Paleontology (357)
  • Pathology (1487)
  • Pharmacology and Toxicology (2581)
  • Physiology (3851)
  • Plant Biology (8351)
  • Scientific Communication and Education (1473)
  • Synthetic Biology (2301)
  • Systems Biology (6205)
  • Zoology (1302)