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Energetic Evolution of Cellular Transportomes

Behrooz Darbani, Douglas B. Kell, Irina Borodina
doi: https://doi.org/10.1101/218396
Behrooz Darbani
1The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800 Lyngby, Denmark
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Douglas B. Kell
2School of Chemistry & Manchester Institute of Biotechnology, The University of Manchester, 131 Princess St, Manchester M1 7DN, United Kingdom
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  • For correspondence: dbk@manchester.ac.uk irbo@biosustain.dtu.dk
Irina Borodina
1The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800 Lyngby, Denmark
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  • For correspondence: dbk@manchester.ac.uk irbo@biosustain.dtu.dk
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ABSTRACT

Transporter proteins mediate the translocation of substances across the membranes of living cells. We performed a genome-wide analysis of the compositional reshaping of cellular transporters (the transportome) across the kingdoms of bacteria, archaea, and eukarya. We show that the transportomes of eukaryotes evolved strongly towards a higher energetic efficiency, as ATP-dependent transporters diminished and secondary transporters and ion channels proliferated. This change has likely been important in the development of tissues performing energetically costly cellular functions. The transportome analysis also indicated seven bacterial species, including Neorickettsia risticii and Neorickettsia sennetsu, as likely origins of the mitochondrion in eukaryotes, due to the restricted presence therein of clear homologues of modern mitochondrial solute carriers.

  • Abbreviations

    ADT
    ATP-dependent transporters
    EUE
    energy-usage efficiency
    IC
    ion-channels
    ST
    secondary transporters
  • Copyright 
    The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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    Posted November 12, 2017.
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    Energetic Evolution of Cellular Transportomes
    Behrooz Darbani, Douglas B. Kell, Irina Borodina
    bioRxiv 218396; doi: https://doi.org/10.1101/218396
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    Energetic Evolution of Cellular Transportomes
    Behrooz Darbani, Douglas B. Kell, Irina Borodina
    bioRxiv 218396; doi: https://doi.org/10.1101/218396

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