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LRRTM1 underlies synaptic convergence in visual thalamus

View ORCID ProfileAboozar Monavarfeshani, Gail Stanton, Jonathan Van Name, Kaiwen Su, William A. Mills III, Kenya Swilling, Alicia Kerr, Jianmin Su, View ORCID ProfileMichael A. Fox
doi: https://doi.org/10.1101/221200
Aboozar Monavarfeshani
1Developmental and Translational Neurobiology Center, Virginia Tech Carilion Research Institute, 2 Riverside Circle, Roanoke, VA
2Department of Biological Sciences, Virginia Tech, Blacksburg, VA 24061
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Gail Stanton
1Developmental and Translational Neurobiology Center, Virginia Tech Carilion Research Institute, 2 Riverside Circle, Roanoke, VA
3Virginia Tech Carilion School of Medicine, Roanoke, VA
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Jonathan Van Name
1Developmental and Translational Neurobiology Center, Virginia Tech Carilion Research Institute, 2 Riverside Circle, Roanoke, VA
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Kaiwen Su
1Developmental and Translational Neurobiology Center, Virginia Tech Carilion Research Institute, 2 Riverside Circle, Roanoke, VA
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William A. Mills III
1Developmental and Translational Neurobiology Center, Virginia Tech Carilion Research Institute, 2 Riverside Circle, Roanoke, VA
4Translational Biology, Medicine, and Health Graduate Program, Virginia Tech, Blacksburg, VA
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Kenya Swilling
1Developmental and Translational Neurobiology Center, Virginia Tech Carilion Research Institute, 2 Riverside Circle, Roanoke, VA
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Alicia Kerr
1Developmental and Translational Neurobiology Center, Virginia Tech Carilion Research Institute, 2 Riverside Circle, Roanoke, VA
4Translational Biology, Medicine, and Health Graduate Program, Virginia Tech, Blacksburg, VA
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Jianmin Su
1Developmental and Translational Neurobiology Center, Virginia Tech Carilion Research Institute, 2 Riverside Circle, Roanoke, VA
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Michael A. Fox
1Developmental and Translational Neurobiology Center, Virginia Tech Carilion Research Institute, 2 Riverside Circle, Roanoke, VA
2Department of Biological Sciences, Virginia Tech, Blacksburg, VA 24061
3Virginia Tech Carilion School of Medicine, Roanoke, VA
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Abstract

It has long been thought that the mammalian visual system is organized into parallel pathways, with incoming visual signals being parsed in the retina based on feature (e.g. color, contrast and motion) and then transmitted to the brain in unmixed, feature-specific channels. To faithfully convey feature-specific information from retina to cortex, thalamic relay cells must receive inputs from only a small number of functionally similar retinal ganglion cells. However, recent studies challenged this by revealing substantial levels of retinal convergence onto relay cells. Here, we sought to identify mechanisms responsible for the assembly of such convergence. Using an unbiased transcriptomics approach and targeted mutant mice, we discovered a critical role for the synaptic adhesion molecule Leucine Rich Repeat Transmembrane Neuronal 1 (LRRTM1) in the emergence of retinothalamic convergence. Importantly, LRRTM1 mutant mice display impairment in visual behaviors, suggesting a functional role of retinothalamic convergence in vision.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted November 17, 2017.
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LRRTM1 underlies synaptic convergence in visual thalamus
Aboozar Monavarfeshani, Gail Stanton, Jonathan Van Name, Kaiwen Su, William A. Mills III, Kenya Swilling, Alicia Kerr, Jianmin Su, Michael A. Fox
bioRxiv 221200; doi: https://doi.org/10.1101/221200
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LRRTM1 underlies synaptic convergence in visual thalamus
Aboozar Monavarfeshani, Gail Stanton, Jonathan Van Name, Kaiwen Su, William A. Mills III, Kenya Swilling, Alicia Kerr, Jianmin Su, Michael A. Fox
bioRxiv 221200; doi: https://doi.org/10.1101/221200

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