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GDF15 Concentrations in Maternal Serum Associated with Vomiting in Pregnancy: the Cambridge Baby Growth Study

View ORCID ProfileClive J. Petry, View ORCID ProfileKen K. Ong, Keith A. Burling, Peter Barker, John R.B. Perry, Carlo L. Acerini, View ORCID ProfileIeuan A. Hughes, View ORCID ProfileDavid B. Dunger, View ORCID ProfileStephen O’Rahilly
doi: https://doi.org/10.1101/221267
Clive J. Petry
1Department of Paediatrics, University of Cambridge, Addenbrooke’s Hospital, Cambridge CB2 0QQ, U.K.
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Ken K. Ong
1Department of Paediatrics, University of Cambridge, Addenbrooke’s Hospital, Cambridge CB2 0QQ, U.K.
2Medical Research Council Epidemiology Unit, Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Addenbrooke’s Hospital, Cambridge CB2 0QQ, U.K.
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Keith A. Burling
3NIHR Biomedical Research Centre Core Biochemistry Assay Lab, Department of Clinical Biochemistry, Addenbrooke’s Hospital, Cambridge CB2 0QQ, U.K.
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Peter Barker
3NIHR Biomedical Research Centre Core Biochemistry Assay Lab, Department of Clinical Biochemistry, Addenbrooke’s Hospital, Cambridge CB2 0QQ, U.K.
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John R.B. Perry
2Medical Research Council Epidemiology Unit, Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Addenbrooke’s Hospital, Cambridge CB2 0QQ, U.K.
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Carlo L. Acerini
1Department of Paediatrics, University of Cambridge, Addenbrooke’s Hospital, Cambridge CB2 0QQ, U.K.
4Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Addenbrooke’s Hospital, Cambridge CB2 0QQ, U.K.
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Ieuan A. Hughes
1Department of Paediatrics, University of Cambridge, Addenbrooke’s Hospital, Cambridge CB2 0QQ, U.K.
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David B. Dunger
1Department of Paediatrics, University of Cambridge, Addenbrooke’s Hospital, Cambridge CB2 0QQ, U.K.
4Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Addenbrooke’s Hospital, Cambridge CB2 0QQ, U.K.
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Stephen O’Rahilly
4Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Addenbrooke’s Hospital, Cambridge CB2 0QQ, U.K.
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Abstract

Nausea and vomiting in pregnancy (NVP) affects 70-90% of all pregnant women but its pathogenesis is unknown. Growth and Differentiation Factor 15 (GDF15), secreted from the trophoblast and decidual stromal cells, is present at high levels in the blood of pregnant women. The receptor for GDF15 has recently been identified and is specifically expressed in the hindbrain where it transmits aversive signals including nausea and conditioned taste aversion. We explored the relationship between GDF15 concentrations in maternal serum during pregnancy and self-reported NVP. In a study of 791 women from the Cambridge Baby Growth Study maternal GDF15 concentrations were higher in women who reported vomiting in the 2nd trimester (geometric mean: 11,670 pg/mL; 95% confidence interval: 11,056-12,318) and were even higher in the eleven women who reported taking anti-emetics during pregnancy (13,376 (10,821-16,535) compared to those who reported no nausea or vomiting during pregnancy (10,657 (10,121-11,222); P=0.02 and P=0.04, respectively, adjusted for gestational age at sampling and maternal BMI). In conclusion serum GDF15 concentrations early in the second trimester of pregnancy are significantly and positively associated with second trimester vomiting and with maternal anti-emetic use. In the context of the recently revealed biology of GDF15 this data suggests that antagonism of GDF15 may have some potential for therapeutic benefit in NVP.

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Posted November 17, 2017.
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GDF15 Concentrations in Maternal Serum Associated with Vomiting in Pregnancy: the Cambridge Baby Growth Study
Clive J. Petry, Ken K. Ong, Keith A. Burling, Peter Barker, John R.B. Perry, Carlo L. Acerini, Ieuan A. Hughes, David B. Dunger, Stephen O’Rahilly
bioRxiv 221267; doi: https://doi.org/10.1101/221267
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GDF15 Concentrations in Maternal Serum Associated with Vomiting in Pregnancy: the Cambridge Baby Growth Study
Clive J. Petry, Ken K. Ong, Keith A. Burling, Peter Barker, John R.B. Perry, Carlo L. Acerini, Ieuan A. Hughes, David B. Dunger, Stephen O’Rahilly
bioRxiv 221267; doi: https://doi.org/10.1101/221267

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