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Binding of the integrated stress response inhibitor, ISRIB, reveals a regulatory site in the nucleotide exchange factor, elF2B
View ORCID ProfileAlisa F. Zyryanova, Félix Weis, Alexandre Faille, Akeel Abo Alard, Ana Crespillo-Casado, Heather P. Harding, Felicity Allen, Leopold Parts, Christophe Fromont, Peter M. Fischer, Alan J. Warren, David Ron
doi: https://doi.org/10.1101/224824
Alisa F. Zyryanova
1Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom
Félix Weis
1Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom
2Department of Haematology, University of Cambridge, Cambridge, UK
3Wellcome Trust–Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK.
4MRC Laboratory of Molecular Biology Francis Crick Avenue Cambridge UK CB2 0QH
Alexandre Faille
1Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom
2Department of Haematology, University of Cambridge, Cambridge, UK
3Wellcome Trust–Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK.
Akeel Abo Alard
5Division of Biomolecular Science & Medicinal Chemistry, School of Pharmacy, University of Nottingham, Nottingham UK NG7 2RD
Ana Crespillo-Casado
1Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom
Heather P. Harding
1Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom
Felicity Allen
6Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK CB10 1SA
Leopold Parts
6Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK CB10 1SA
Christophe Fromont
5Division of Biomolecular Science & Medicinal Chemistry, School of Pharmacy, University of Nottingham, Nottingham UK NG7 2RD
Peter M. Fischer
5Division of Biomolecular Science & Medicinal Chemistry, School of Pharmacy, University of Nottingham, Nottingham UK NG7 2RD
Alan J. Warren
1Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom
2Department of Haematology, University of Cambridge, Cambridge, UK
3Wellcome Trust–Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK.
4MRC Laboratory of Molecular Biology Francis Crick Avenue Cambridge UK CB2 0QH
David Ron
1Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom
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Posted November 25, 2017.
Binding of the integrated stress response inhibitor, ISRIB, reveals a regulatory site in the nucleotide exchange factor, elF2B
Alisa F. Zyryanova, Félix Weis, Alexandre Faille, Akeel Abo Alard, Ana Crespillo-Casado, Heather P. Harding, Felicity Allen, Leopold Parts, Christophe Fromont, Peter M. Fischer, Alan J. Warren, David Ron
bioRxiv 224824; doi: https://doi.org/10.1101/224824
Binding of the integrated stress response inhibitor, ISRIB, reveals a regulatory site in the nucleotide exchange factor, elF2B
Alisa F. Zyryanova, Félix Weis, Alexandre Faille, Akeel Abo Alard, Ana Crespillo-Casado, Heather P. Harding, Felicity Allen, Leopold Parts, Christophe Fromont, Peter M. Fischer, Alan J. Warren, David Ron
bioRxiv 224824; doi: https://doi.org/10.1101/224824
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