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Penetrance of polygenic obesity susceptibility loci across the body mass index distribution: an update on scaling effects

Arkan Abadi, Akram Alyass, Sebastien Robiou du Pont, Ben Bolker, Pardeep Singh, Viswanathan Mohan, Rafael Diaz, James C. Engert, Hertzel C. Gerstein, Sonia S. Anand, David Meyre
doi: https://doi.org/10.1101/225128
Arkan Abadi
1Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON L8S 4L8 Canada
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Akram Alyass
1Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON L8S 4L8 Canada
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Sebastien Robiou du Pont
1Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON L8S 4L8 Canada
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Ben Bolker
2Department of Mathematics and Statistics, McMaster University, Hamilton, ON L8S 4L8 Canada
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Pardeep Singh
3Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON L8S 4L8 Canada
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Viswanathan Mohan
4Madras Diabetes Research Foundation, Chennai, India
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Rafael Diaz
5ECLA-Academic Research Organization, Rosario, Argentina
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James C. Engert
6McGill University, Montreal, QC H3A 0G4 Canada
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Hertzel C. Gerstein
1Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON L8S 4L8 Canada
7Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton General Hospital, Hamilton, ON L8S 4L8 Canada
8Department of Medicine, McMaster University, Hamilton, ON L8S 4L8 Canada
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Sonia S. Anand
1Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON L8S 4L8 Canada
7Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton General Hospital, Hamilton, ON L8S 4L8 Canada
8Department of Medicine, McMaster University, Hamilton, ON L8S 4L8 Canada
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David Meyre
1Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON L8S 4L8 Canada
3Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON L8S 4L8 Canada
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  • For correspondence: mevred@mcmaster.ca
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Article Information

doi 
https://doi.org/10.1101/225128
History 
  • November 29, 2017.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Arkan Abadi1,9,
  2. Akram Alyass1,9,
  3. Sebastien Robiou du Pont1,
  4. Ben Bolker2,
  5. Pardeep Singh3,
  6. Viswanathan Mohan4,
  7. Rafael Diaz5,
  8. James C. Engert6,
  9. Hertzel C. Gerstein1,7,8,
  10. Sonia S. Anand1,7,8 and
  11. David Meyre1,3,*
  1. 1Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON L8S 4L8 Canada
  2. 2Department of Mathematics and Statistics, McMaster University, Hamilton, ON L8S 4L8 Canada
  3. 3Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON L8S 4L8 Canada
  4. 4Madras Diabetes Research Foundation, Chennai, India
  5. 5ECLA-Academic Research Organization, Rosario, Argentina
  6. 6McGill University, Montreal, QC H3A 0G4 Canada
  7. 7Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton General Hospital, Hamilton, ON L8S 4L8 Canada
  8. 8Department of Medicine, McMaster University, Hamilton, ON L8S 4L8 Canada
  1. ↵*Correspondence: mevred{at}mcmaster.ca (D.M.)
  1. ↵9 These authors contributed equally to this work

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Posted November 29, 2017.
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Penetrance of polygenic obesity susceptibility loci across the body mass index distribution: an update on scaling effects
Arkan Abadi, Akram Alyass, Sebastien Robiou du Pont, Ben Bolker, Pardeep Singh, Viswanathan Mohan, Rafael Diaz, James C. Engert, Hertzel C. Gerstein, Sonia S. Anand, David Meyre
bioRxiv 225128; doi: https://doi.org/10.1101/225128
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Penetrance of polygenic obesity susceptibility loci across the body mass index distribution: an update on scaling effects
Arkan Abadi, Akram Alyass, Sebastien Robiou du Pont, Ben Bolker, Pardeep Singh, Viswanathan Mohan, Rafael Diaz, James C. Engert, Hertzel C. Gerstein, Sonia S. Anand, David Meyre
bioRxiv 225128; doi: https://doi.org/10.1101/225128

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