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Fast Intensity Adaptation Enhances the Encoding of Sound in Drosophila

View ORCID ProfileJan Clemens, Nofar Ozeri-Engelhard, Mala Murthy
doi: https://doi.org/10.1101/228213
Jan Clemens
1Princeton Neuroscience Institute, Washington Road, Princeton University, Princeton 08540, NJ, USA
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  • ORCID record for Jan Clemens
Nofar Ozeri-Engelhard
1Princeton Neuroscience Institute, Washington Road, Princeton University, Princeton 08540, NJ, USA
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Mala Murthy
1Princeton Neuroscience Institute, Washington Road, Princeton University, Princeton 08540, NJ, USA
3Department of Molecular Biology, Princeton University, Princeton, NJ, USA
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Abstract

To faithfully encode complex stimuli, sensory neurons should correct, via adaptation, for stimulus properties that corrupt pattern recognition. Here, we investigate sound intensity adaptation in the Drosophila auditory system, which is largely devoted to processing courtship song. Mechanosensory neurons (JONs) in the antenna are sensitive not only to sound-induced antennal vibrations, but also to wind or gravity, which affect the antenna’s mean position. Song pattern recognition therefore requires adaptation to antennal position (stimulus mean) in addition to sound intensity (stimulus variance). We discover fast variance adaptation in Drosophila JONs, which corrects for background noise over the behaviorally relevant intensity range. We determine where mean and variance adaptation arises and how they interact. A computational model explains our results using a sequence of subtractive and divisive adaptation modules, interleaved by rectification. These results lay the foundation for identifying the molecular and biophysical implementation of adaptation to the statistics of natural sensory stimuli.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted December 03, 2017.
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Fast Intensity Adaptation Enhances the Encoding of Sound in Drosophila
Jan Clemens, Nofar Ozeri-Engelhard, Mala Murthy
bioRxiv 228213; doi: https://doi.org/10.1101/228213
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Fast Intensity Adaptation Enhances the Encoding of Sound in Drosophila
Jan Clemens, Nofar Ozeri-Engelhard, Mala Murthy
bioRxiv 228213; doi: https://doi.org/10.1101/228213

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