Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

TIMELINE OF BRAIN ALTERATIONS IN ALZHEIMER’S DISEASE ACROSS THE ENTIRE LIFESPAN

Pierrick Coupé, José Vicente Manjón, Enrique Lanuza, Gwenaelle Catheline, for the Alzheimer’s Disease Neuroimaging Initiative
doi: https://doi.org/10.1101/229195
Pierrick Coupé
aUniv. Bordeaux, LaBRI, UMR 5800, PICTURA, F-33400 Talence, France.
bCNRS, LaBRI, UMR 5800, PICTURA, F-33400 Talence, France.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: Pierrick.coupe@u-bordeaux.fr
José Vicente Manjón
cInstituto Universitario de Tecnologías de la Información y Comunicaciones (ITACA), Universitat Politècnica de València, Camino de Vera s/n, 46022 Valencia, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Enrique Lanuza
dUniv. Valencia, Dept. of Cell Biology, Burjassot 46100, Valencia, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gwenaelle Catheline
eUniv. Bordeaux, CNRS, EPHE PSL Research Univ., INCIA, UMR 5283, F-33000 Bordeaux
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

Brain imaging studies have shown that progressive cerebral atrophy characterized the development of Alzheimer’s Disease (AD). The key question is how long before the diagnosis of AD the neurodegenerative process started leading to these structural alterations. To answer this question, we proposed an innovative way by inferring brain structure volume trajectories across the entire lifespan using massive number of MRI (N=4714). Our study provides evidences of early divergence of the AD model from the control model for the hippocampus before 40 years, followed by the lateral ventricles and the amygdala around 40 years for the AD model. Moreover, our lifespan investigation reveals the dynamic of the evolution of these biomarkers and suggest close abnormality trajectories for the hippocampus and the amygdala. Finally, our results highlight that the temporal lobe atrophy, a key biomarker in AD, is a very early pathophysiological event potentially associated to early life exposures to risk factors.

Footnotes

  • ↵* Data used in preparation of this article were obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database (adni.loni.usc.edu). As such, the investigators within the ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in analysis or writing of this report. A complete listing of ADNI investigators can be found at: http://adni.loni.usc.edu/wpcontent/uploads/how_to_apply/ADNI_Acknowledgement_List.pdf

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Back to top
PreviousNext
Posted December 07, 2017.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
TIMELINE OF BRAIN ALTERATIONS IN ALZHEIMER’S DISEASE ACROSS THE ENTIRE LIFESPAN
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
TIMELINE OF BRAIN ALTERATIONS IN ALZHEIMER’S DISEASE ACROSS THE ENTIRE LIFESPAN
Pierrick Coupé, José Vicente Manjón, Enrique Lanuza, Gwenaelle Catheline, for the Alzheimer’s Disease Neuroimaging Initiative
bioRxiv 229195; doi: https://doi.org/10.1101/229195
Digg logo Reddit logo Twitter logo Facebook logo Google logo LinkedIn logo Mendeley logo
Citation Tools
TIMELINE OF BRAIN ALTERATIONS IN ALZHEIMER’S DISEASE ACROSS THE ENTIRE LIFESPAN
Pierrick Coupé, José Vicente Manjón, Enrique Lanuza, Gwenaelle Catheline, for the Alzheimer’s Disease Neuroimaging Initiative
bioRxiv 229195; doi: https://doi.org/10.1101/229195

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (3691)
  • Biochemistry (7800)
  • Bioengineering (5678)
  • Bioinformatics (21295)
  • Biophysics (10584)
  • Cancer Biology (8179)
  • Cell Biology (11948)
  • Clinical Trials (138)
  • Developmental Biology (6764)
  • Ecology (10401)
  • Epidemiology (2065)
  • Evolutionary Biology (13876)
  • Genetics (9709)
  • Genomics (13075)
  • Immunology (8151)
  • Microbiology (20022)
  • Molecular Biology (7859)
  • Neuroscience (43075)
  • Paleontology (321)
  • Pathology (1279)
  • Pharmacology and Toxicology (2261)
  • Physiology (3353)
  • Plant Biology (7232)
  • Scientific Communication and Education (1314)
  • Synthetic Biology (2008)
  • Systems Biology (5539)
  • Zoology (1128)