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Optogenetic dissection of descending behavioral control in Drosophila

Jessica Cande, View ORCID ProfileGordon J. Berman, View ORCID ProfileShigehiro Namiki, Jirui Qiu, View ORCID ProfileWyatt Korff, Gwyneth Card, Joshua W. Shaevitz, View ORCID ProfileDavid L. Stern
doi: https://doi.org/10.1101/230128
Jessica Cande
1Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147.
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Gordon J. Berman
2Department of Biology, Emory University, Atlanta, Georgia 30322.
3Department of Physics, Emory University, Atlanta, Georgia 30322.
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Shigehiro Namiki
1Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147.
4Research Center for Advanced Science and Technology, University of Tokyo, Tokyo 153-8904, Japan.
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Jirui Qiu
3Department of Physics, Emory University, Atlanta, Georgia 30322.
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Wyatt Korff
1Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147.
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Gwyneth Card
1Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147.
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Joshua W. Shaevitz
5Department of Physics and the Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544.
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David L. Stern
1Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147.
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Abstract

In most animals, the brain makes behavioral decisions that are transmitted by descending neurons to the nerve cord circuitry that produces behaviors. In insects, only a few descending neurons have been associated with specific behaviors. To explore how these neurons control an insect’s movements, we developed a novel method to systematically assay the behavioral effects of activating individual neurons on freely behaving terrestrial D. melanogaster. We calculated a two-dimensional representation of the entire behavior space explored by these flies and associated descending neurons with specific behaviors by identifying regions of this space that were visited with increased frequency during optogenetic activation. Applying this approach across a population of descending neurons, we found, that (1) activation of most of the descending neurons drove stereotyped behaviors, (2) in many cases multiple descending neurons activated similar behaviors, and (3) optogenetically-activated behaviors were often dependent on the behavioral state prior to activation.

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Posted December 09, 2017.
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Optogenetic dissection of descending behavioral control in Drosophila
Jessica Cande, Gordon J. Berman, Shigehiro Namiki, Jirui Qiu, Wyatt Korff, Gwyneth Card, Joshua W. Shaevitz, David L. Stern
bioRxiv 230128; doi: https://doi.org/10.1101/230128
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Optogenetic dissection of descending behavioral control in Drosophila
Jessica Cande, Gordon J. Berman, Shigehiro Namiki, Jirui Qiu, Wyatt Korff, Gwyneth Card, Joshua W. Shaevitz, David L. Stern
bioRxiv 230128; doi: https://doi.org/10.1101/230128

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