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Similar clinical improvement and maintenance after rTMS at 5 Hz using a simple vs. complex protocol in Alzheimer’s disease

R. Alcalá-Lozano, E. Morelos-Santana, J.F. Cortés-Sotres, E. A. Garza-Villarreal, A. L. Sosa-Ortiz, J. J. Gonzalez-Olvera
doi: https://doi.org/10.1101/232546
R. Alcalá-Lozano
1Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría “Ramón de la Fuente Muñiz”, Mexico City, Mexico
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E. Morelos-Santana
1Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría “Ramón de la Fuente Muñiz”, Mexico City, Mexico
2Facultad de Psicología, Universidad Nacional Autónoma de México, Mexico City, Mexico
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J.F. Cortés-Sotres
3Departmento de Apoyo Académico y Posgrado, Instituto Nacional de Psiquiatría “Ramón de la Fuente Muñiz”, Mexico City, Mexico.
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E. A. Garza-Villarreal
1Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría “Ramón de la Fuente Muñiz”, Mexico City, Mexico
4Department of Clinical Medicine & Center of Functionally Integrative Neuroscience/MINDLAB, University of Aarhus, Denmark
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A. L. Sosa-Ortiz
5Dementia Laboratory, Instituto Nacional de Neurología y Neurocirugía “Manuel Velasco Suárez”, Mexico City, Mexico
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J. J. Gonzalez-Olvera
1Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría “Ramón de la Fuente Muñiz”, Mexico City, Mexico
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Abstract

Brackground Current treatments for Alzheimer’s disease (AD) have a limited clinical response and methods, such as repetitive transcranial magnetic stimulation (rTMS), are being studied as possible treatments for the clinical symptoms with positive results. However, there is still seldom information on the type of rTMS protocols that deliver the best clinical improvement in AD.

Objetive To compare the clinical response between a simple stimulation protocol on the left dorsolateral prefrontal cortex (lDLPFC) against a complex protocol using six regions of interest.

Methods 19 participants were randomized to receive any of the protocols. The analysis of repeated measures evaluated the change.

Results Both protocols were equally proficient at improving cognitive function, behavior and functionality after 3 weeks of treatment, and the effects were maintained for 4 weeks more without treatment.

Conclusion We suggest rTMS on the lDLPFC could be enough to provide a clinical response, and the underlying mechanisms should be studied.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
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Posted December 13, 2017.
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Similar clinical improvement and maintenance after rTMS at 5 Hz using a simple vs. complex protocol in Alzheimer’s disease
R. Alcalá-Lozano, E. Morelos-Santana, J.F. Cortés-Sotres, E. A. Garza-Villarreal, A. L. Sosa-Ortiz, J. J. Gonzalez-Olvera
bioRxiv 232546; doi: https://doi.org/10.1101/232546
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Similar clinical improvement and maintenance after rTMS at 5 Hz using a simple vs. complex protocol in Alzheimer’s disease
R. Alcalá-Lozano, E. Morelos-Santana, J.F. Cortés-Sotres, E. A. Garza-Villarreal, A. L. Sosa-Ortiz, J. J. Gonzalez-Olvera
bioRxiv 232546; doi: https://doi.org/10.1101/232546

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