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Intrinsic neuronal dynamics predict distinct functional roles during working memory

DF Wasmuht, E Spaak, TJ Buschman, EK Miller, MG Stokes
doi: https://doi.org/10.1101/233171
DF Wasmuht
1Department of Experimental Psychology, University of Oxford, Oxford, OX1 3UD, United Kingdom.
2Oxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, Department of Psychiatry, University of Oxford, Oxford, OX3 7JX, United Kingdom.
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E Spaak
1Department of Experimental Psychology, University of Oxford, Oxford, OX1 3UD, United Kingdom.
2Oxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, Department of Psychiatry, University of Oxford, Oxford, OX3 7JX, United Kingdom.
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TJ Buschman
3Princeton Neuroscience Institute and Department of Psychology, Princeton, NJ 08544, USA.
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EK Miller
4The Picower Institute for Learning and Memory and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology. Cambridge, MA 02139, USA.
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MG Stokes
1Department of Experimental Psychology, University of Oxford, Oxford, OX1 3UD, United Kingdom.
2Oxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, Department of Psychiatry, University of Oxford, Oxford, OX3 7JX, United Kingdom.
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Abstract

Working memory (WM) is characterized by the ability to maintain stable representations over time; however, neural activity associated with WM maintenance can be highly dynamic. We explore whether complex population coding dynamics during WM relate to the intrinsic temporal properties of single neurons in lateral prefrontal cortex (lPFC), the frontal eye fields (FEF) and lateral intraparietal cortex (LIP) of two monkeys (Macaca mulatta). We found that cells with short timescales carried memory information relatively early during memory encoding in lPFC; whereas long timescale cells played a greater role later during processing, dominating coding in the delay period. We also observed a link between functional connectivity at rest and intrinsic timescale in FEF and LIP. Our results indicate that individual differences in the temporal processing capacity predicts complex neuronal dynamics during WM; ranging from rapid dynamic encoding of stimuli to slower, but stable, maintenance of mnemonic information.

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Posted December 14, 2017.
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Intrinsic neuronal dynamics predict distinct functional roles during working memory
DF Wasmuht, E Spaak, TJ Buschman, EK Miller, MG Stokes
bioRxiv 233171; doi: https://doi.org/10.1101/233171
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Intrinsic neuronal dynamics predict distinct functional roles during working memory
DF Wasmuht, E Spaak, TJ Buschman, EK Miller, MG Stokes
bioRxiv 233171; doi: https://doi.org/10.1101/233171

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