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Genome-wide association analysis of lifetime cannabis use (N=184,765) identifies new risk loci, genetic overlap with mental health, and a causal influence of schizophrenia on cannabis use
View ORCID ProfileJoëlle A. Pasman, Karin J.H. Verweij, Zachary Gerring, Sven Stringer, Sandra Sanchez-Roige, Jorien L. Treur, Abdel Abdellaoui, Michel G. Nivard, Bart M.L. Baselmans, Jue-Sheng Ong, Hill F. Ip, Matthijs D. van der Zee, Meike Bartels, Felix R. Day, Pierre Fontanillas, Sarah L. Elson, the 23andMe Research Team, Harriet de Wit, Lea K. Davis, James MacKillop, International Cannabis Consortium, Jaime L. Derringer, Susan J.T. Branje, Catharina A. Hartman, Andrew C. Heath, Pol A.C. van Lier, Pamela A.F. Madden, Reedik Mägi, Wim Meeus, Grant W. Montgomery, A.J. Oldehinkel, Zdenka Pausova, Josep A. Ramos-Quiroga, Tomas Paus, Marta Ribases, Jaakko Kaprio, Marco P.M. Boks, Jordana T. Bell, Tim D. Spector, Joel Gelernter, Dorret I. Boomsma, Nicholas G. Martin, Stuart MacGregor, John R.B. Perry, Abraham A. Palmer, Danielle Posthuma, Marcus R. Munafò, Nathan A. Gillespie, Eske M. Derks, Jacqueline M. Vink
doi: https://doi.org/10.1101/234294
Joëlle A. Pasman
1Behavioural Science Institute, Radboud University, Nijmegen, The Netherlands
Karin J.H. Verweij
1Behavioural Science Institute, Radboud University, Nijmegen, The Netherlands
Zachary Gerring
2Genetic Epidemiology, Statistical Genetics, and Translational Neurogenomics laboratories, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
Sven Stringer
3Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
Sandra Sanchez-Roige
4University of California San Diego, Department of Psychiatry, La Jolla, United States of America
Jorien L. Treur
5MRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, United Kingdom
Abdel Abdellaoui
6Department of Biological Psychology/Netherlands Twin Register, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
Michel G. Nivard
6Department of Biological Psychology/Netherlands Twin Register, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
Bart M.L. Baselmans
6Department of Biological Psychology/Netherlands Twin Register, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
Jue-Sheng Ong
2Genetic Epidemiology, Statistical Genetics, and Translational Neurogenomics laboratories, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
Hill F. Ip
6Department of Biological Psychology/Netherlands Twin Register, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
Matthijs D. van der Zee
6Department of Biological Psychology/Netherlands Twin Register, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
Meike Bartels
6Department of Biological Psychology/Netherlands Twin Register, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
Felix R. Day
7MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, United Kingdom
Pierre Fontanillas
823andMe, Inc., Mountain View, United States of America
Sarah L. Elson
823andMe, Inc., Mountain View, United States of America
823andMe, Inc., Mountain View, United States of America
Harriet de Wit
9Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, United States of America
Lea K. Davis
10Vanderbilt Genetics Institute; Division of Genetic Medicine, Department of Medicine, Vanderbilt University, Nashville, United States of America
James MacKillop
11Peter Boris Centre for Addictions Research and Michael G. DeGroote Centre for Medicinal Cannabis Research, McMaster University/St. Joseph's Healthcare Hamilton, Hamilton, Canada
Jaime L. Derringer
12Department of Psychology, University of Illinois Urbana-Champaign, Champaign, United States of America
Susan J.T. Branje
13Department of Youth and Family, Utrecht University, Utrecht, The Netherlands
Catharina A. Hartman
14Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
Andrew C. Heath
15Department of Psychiatry, Washington University School of Medicine, St. Louis (MO), United States of America
Pol A.C. van Lier
16Department of Developmental Psychology and EMGO Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
Pamela A.F. Madden
15Department of Psychiatry, Washington University School of Medicine, St. Louis (MO), United States of America
Reedik Mägi
17Estonian Genome Center, University of Tartu, Tartu, Estonia
Wim Meeus
13Department of Youth and Family, Utrecht University, Utrecht, The Netherlands
Grant W. Montgomery
18Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia
A.J. Oldehinkel
14Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
Zdenka Pausova
19Hospital for Sick Children, Toronto, Canada
Josep A. Ramos-Quiroga
20Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d’Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Spain
21Department of Psychiatry, Hospital Universitari Vall d’Hebron, Barcelona, Spain
22Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain
23Department of Psychiatry and Legal Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain
Tomas Paus
24Rotman Research Institute, Baycrest, Toronto, Canada
25Departments of Psychology and Psychiatry, University of Toronto, Toronto, Canada
Marta Ribases
20Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d’Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Spain
21Department of Psychiatry, Hospital Universitari Vall d’Hebron, Barcelona, Spain
22Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain
Jaakko Kaprio
26Institute for Molecular Medicine Finland FIMM, HiLIFE Unit, University of Helsinki, Helsinki, Finland
Marco P.M. Boks
27Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
Jordana T. Bell
28Department of Twin Research and Genetic Epidemiology, King’s College London, London, United Kingdom
Tim D. Spector
28Department of Twin Research and Genetic Epidemiology, King’s College London, London, United Kingdom
Joel Gelernter
29Department of Psychiatry, Yale University School of Medicine, New Haven (CT), United States of America
Dorret I. Boomsma
6Department of Biological Psychology/Netherlands Twin Register, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
Nicholas G. Martin
2Genetic Epidemiology, Statistical Genetics, and Translational Neurogenomics laboratories, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
Stuart MacGregor
2Genetic Epidemiology, Statistical Genetics, and Translational Neurogenomics laboratories, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
John R.B. Perry
7MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, United Kingdom
Abraham A. Palmer
4University of California San Diego, Department of Psychiatry, La Jolla, United States of America
30University of California San Diego, Institute for Genomic Medicine, La Jolla, United States of America
Danielle Posthuma
3Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
Marcus R. Munafò
5MRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, United Kingdom
31UK Centre for Tobacco and Alcohol Studies and School of Experimental Psychology, University of Bristol, Bristol, United Kingdom
Nathan A. Gillespie
2Genetic Epidemiology, Statistical Genetics, and Translational Neurogenomics laboratories, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
32Department of Psychiatry, Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, Virginia, United States of America
Eske M. Derks
2Genetic Epidemiology, Statistical Genetics, and Translational Neurogenomics laboratories, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
Jacqueline M. Vink
1Behavioural Science Institute, Radboud University, Nijmegen, The Netherlands
Article usage
Posted January 08, 2018.
Genome-wide association analysis of lifetime cannabis use (N=184,765) identifies new risk loci, genetic overlap with mental health, and a causal influence of schizophrenia on cannabis use
Joëlle A. Pasman, Karin J.H. Verweij, Zachary Gerring, Sven Stringer, Sandra Sanchez-Roige, Jorien L. Treur, Abdel Abdellaoui, Michel G. Nivard, Bart M.L. Baselmans, Jue-Sheng Ong, Hill F. Ip, Matthijs D. van der Zee, Meike Bartels, Felix R. Day, Pierre Fontanillas, Sarah L. Elson, the 23andMe Research Team, Harriet de Wit, Lea K. Davis, James MacKillop, International Cannabis Consortium, Jaime L. Derringer, Susan J.T. Branje, Catharina A. Hartman, Andrew C. Heath, Pol A.C. van Lier, Pamela A.F. Madden, Reedik Mägi, Wim Meeus, Grant W. Montgomery, A.J. Oldehinkel, Zdenka Pausova, Josep A. Ramos-Quiroga, Tomas Paus, Marta Ribases, Jaakko Kaprio, Marco P.M. Boks, Jordana T. Bell, Tim D. Spector, Joel Gelernter, Dorret I. Boomsma, Nicholas G. Martin, Stuart MacGregor, John R.B. Perry, Abraham A. Palmer, Danielle Posthuma, Marcus R. Munafò, Nathan A. Gillespie, Eske M. Derks, Jacqueline M. Vink
bioRxiv 234294; doi: https://doi.org/10.1101/234294
Genome-wide association analysis of lifetime cannabis use (N=184,765) identifies new risk loci, genetic overlap with mental health, and a causal influence of schizophrenia on cannabis use
Joëlle A. Pasman, Karin J.H. Verweij, Zachary Gerring, Sven Stringer, Sandra Sanchez-Roige, Jorien L. Treur, Abdel Abdellaoui, Michel G. Nivard, Bart M.L. Baselmans, Jue-Sheng Ong, Hill F. Ip, Matthijs D. van der Zee, Meike Bartels, Felix R. Day, Pierre Fontanillas, Sarah L. Elson, the 23andMe Research Team, Harriet de Wit, Lea K. Davis, James MacKillop, International Cannabis Consortium, Jaime L. Derringer, Susan J.T. Branje, Catharina A. Hartman, Andrew C. Heath, Pol A.C. van Lier, Pamela A.F. Madden, Reedik Mägi, Wim Meeus, Grant W. Montgomery, A.J. Oldehinkel, Zdenka Pausova, Josep A. Ramos-Quiroga, Tomas Paus, Marta Ribases, Jaakko Kaprio, Marco P.M. Boks, Jordana T. Bell, Tim D. Spector, Joel Gelernter, Dorret I. Boomsma, Nicholas G. Martin, Stuart MacGregor, John R.B. Perry, Abraham A. Palmer, Danielle Posthuma, Marcus R. Munafò, Nathan A. Gillespie, Eske M. Derks, Jacqueline M. Vink
bioRxiv 234294; doi: https://doi.org/10.1101/234294
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