Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Coherent representations of subjective spatial position in primary visual cortex and hippocampus

View ORCID ProfileAman B. Saleem, E. Mika Diamanti, View ORCID ProfileJulien Fournier, View ORCID ProfileKenneth D. Harris, View ORCID ProfileMatteo Carandini
doi: https://doi.org/10.1101/235648
Aman B. Saleem
1UCL Institute of Ophthalmology, University College London, London, EC1V9EL, UK,
2Department of Experimental Psychology, University College London, London, WC1H 0AP, UK,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Aman B. Saleem
E. Mika Diamanti
1UCL Institute of Ophthalmology, University College London, London, EC1V9EL, UK,
3CoMPLEX, Department of Computer Science, University College London, London, WC1E 6BT, UK,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Julien Fournier
1UCL Institute of Ophthalmology, University College London, London, EC1V9EL, UK,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Julien Fournier
Kenneth D. Harris
4UCL Institute of Neurology, University College London, London, WC1N 3BG, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Kenneth D. Harris
Matteo Carandini
1UCL Institute of Ophthalmology, University College London, London, EC1V9EL, UK,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Matteo Carandini
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

A major role of vision is to guide navigation, and navigation is strongly driven by vision1-4. Indeed, the brain’s visual and navigational systems are known to interact5, 6, and signals related to position in the environment have been suggested to appear as early as in visual cortex6, 7. To establish the nature of these signals we recorded in primary visual cortex (V1) and in the CA1 region of the hippocampus while mice traversed a corridor in virtual reality. The corridor contained identical visual landmarks in two positions, so that a purely visual neuron would respond similarly in those positions. Most V1 neurons, however, responded solely or more strongly to the landmarks in one position. This modulation of visual responses by spatial location was not explained by factors such as running speed. To assess whether the modulation is related to navigational signals and to the animal’s subjective estimate of position, we trained the mice to lick for a water reward upon reaching a reward zone in the corridor. Neuronal populations in both CA1 and V1 encoded the animal’s position along the corridor, and the errors in their representations were correlated. Moreover, both representations reflected the animal’s subjective estimate of position, inferred from the animal’s licks, better than its actual position. Indeed, when animals licked in a given location – whether correct or incorrect – neural populations in both V1 and CA1 placed the animal in the reward zone. We conclude that visual responses in V1 are tightly controlled by navigational signals, which are coherent with those encoded in hippocampus, and reflect the animal’s subjective position in the environment. The presence of such navigational signals as early as in a primary sensory area suggests that these signals permeate sensory processing in the cortex.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted December 18, 2017.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Coherent representations of subjective spatial position in primary visual cortex and hippocampus
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Coherent representations of subjective spatial position in primary visual cortex and hippocampus
Aman B. Saleem, E. Mika Diamanti, Julien Fournier, Kenneth D. Harris, Matteo Carandini
bioRxiv 235648; doi: https://doi.org/10.1101/235648
Reddit logo Twitter logo Facebook logo LinkedIn logo Mendeley logo
Citation Tools
Coherent representations of subjective spatial position in primary visual cortex and hippocampus
Aman B. Saleem, E. Mika Diamanti, Julien Fournier, Kenneth D. Harris, Matteo Carandini
bioRxiv 235648; doi: https://doi.org/10.1101/235648

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (4397)
  • Biochemistry (9629)
  • Bioengineering (7123)
  • Bioinformatics (24937)
  • Biophysics (12670)
  • Cancer Biology (9994)
  • Cell Biology (14400)
  • Clinical Trials (138)
  • Developmental Biology (7989)
  • Ecology (12147)
  • Epidemiology (2067)
  • Evolutionary Biology (16025)
  • Genetics (10951)
  • Genomics (14778)
  • Immunology (9905)
  • Microbiology (23739)
  • Molecular Biology (9506)
  • Neuroscience (51049)
  • Paleontology (370)
  • Pathology (1545)
  • Pharmacology and Toxicology (2692)
  • Physiology (4038)
  • Plant Biology (8693)
  • Scientific Communication and Education (1512)
  • Synthetic Biology (2404)
  • Systems Biology (6458)
  • Zoology (1350)