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History
- December 23, 2017.
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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Author Information
- Esther Rheinbay1,*,
- Morten Muhlig Nielsen2,*,
- Federico Abascal3,*,
- Grace Tiao1,#,
- Henrik Hornshøj2,#,
- Julian M. Hess1,#,
- Randi Istrup Pedersen2,#,
- Lars Feuerbach4,
- Radhakrishnan Sabarinathan5,6,
- Tobias Madsen2,
- Jaegil Kim1,
- Loris Mularoni5,6,
- Shimin Shuai18,
- Andrés Lanzós8,9,
- Carl Herrmann10,11,
- Yosef E. Maruvka1,12,
- Ciyue Shen13,14,
- Samirkumar B. Amin15,16,
- Johanna Bertl2,
- Priyanka Dhingra17,18,
- Klev Diamanti19,
- Abel Gonzalez-Perez5,6,
- Qianyun Guo20,
- Nicholas J. Haradhvala1,12,
- Keren Isaev21,22,
- Malene Juul2,
- Jan Komorowski19,23,
- Sushant Kumar24,
- Donghoon Lee24,
- Lucas Lochovsky25,
- Eric Minwei Liu17,18,
- Oriol Pich5,6,
- David Tamborero5,6,
- Husen M. Umer19,
- Liis Uusküla-Reimand26,27,
- Claes Wadelius28,
- Lina Wadi21,
- Jing Zhang24,
- Keith A. Boroevich29,
- Joana Carlevaro-Fita8,9,
- Dimple Chakravarty30,
- Calvin W.Y. Chan10,33,
- Nuno A. Fonseca31,
- Mark P. Hamilton32,
- Chen Hong4,33,
- Andre Kahles34,
- Youngwook Kim35,
- Kjong-Van Lehmann34,
- Todd A. Johnson29,
- Abdullah Kahraman36,
- Keunchil Park35,
- Gordon Saksena1,
- Lina Sieverling4,33,
- Nicholas A. Sinnott-Armstrong37,
- Peter J. Campbell3,38,
- Asger Hobolth20,
- Manolis Kellis1,39,
- Michael S. Lawrence1,12,
- Ben Raphael40,
- Mark A. Rubin41,42,43,
- Chris Sander13,14,
- Lincoln Stein7,21,44,
- Josh Stuart45,
- Tatsuhiko Tsunoda46,47,48,
- David A. Wheeler49,
- Rory Johnson50,
- Jüri Reimand21,22,
- Mark B. Gerstein51,52,53,
- Ekta Khurana17,18,42,43,
- Núria López-Bigas5,6,54,
- Iñigo Martincorena3,&,
- Jakob Skou Pedersen2,20,&,
- Gad Getz1,12,55,56,&,
- on behalf of the PCAWG Drivers and Functional Interpretation Group and the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Network
- 1The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02124, USA
- 2Department of Molecular Medicine (MOMA), Aarhus University Hospital, Aarhus, Denmark
- 3Wellcome Trust Sanger Institute, Hinxton CB10 1SA, Cambridgeshire, UK
- 4Division of Applied Bioinformatics, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany
- 5Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac, 10, 08028 Barcelona, Spain
- 6Research Program on Biomedical Informatics, Universitat Pompeu Fabra, Barcelona, Spain
- 7Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
- 8Centre for Genomic Regulation (CRG), Barcelona 08003, Spain
- 9Universitat Pompeu Fabra (UPF), Barcelona, Spain
- 10Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
- 11Institute of Pharmacy and Molecular Biotechnology, and Bioquant Center, University of Heidelberg, 69120 Heidelberg, Germany
- 12Massachusetts General Hospital, Center for Cancer Research, Charlestown, Massachusetts 02129, USA
- 13Department of Cell Biology, Harvard Medical School, Boston, MA, USA
- 14cBio Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston
- 15Department of Genomic Medicine, the University of Texas MD Anderson Cancer Center, Houston, Texas, USA
- 16Graduate Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, Texas, USA
- 17Department of Physiology and Biophysics, Weill Cornell Medicine, 1300 York Avenue, New York, NY, 10065, USA
- 18Institute for Computational Biomedicine, Weill Cornell Medical College, New York, New York 10021 USA
- 19Computational Biology and Bioinformatics, Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden
- 20Bioinformatics Research Centre (BiRC), Aarhus University, Aarhus, Denmark
- 21Computational Biology Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada
- 22Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
- 23Institute of Computer Science, Polish Academy of Sciences, Warsaw, 01-248, Poland
- 24Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut 06520, USA
- 25Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA
- 26Genetics and Genome Biology Program, SickKids Research Institute, Toronto, ON, Canada
- 27Department of Gene Technology, Tallinn University of Technology, Estonia
- 28Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
- 29Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
- 30Department of Genitourinary Medical Oncology - Research, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
- 31European Bioinformatics Institute. European Molecular Biology Laboratory. Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, UK
- 32Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza Houston M822, Houston, Texas 77030, USA
- 33Faculty of Biosciences, Heidelberg University, Im Neuenheimer Feld 234, 69120 Heidelberg, Germany
- 34Division of Computational Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
- 35Samsung Medical Center, Sungkyunkwan University School of Medicine South Korea
- 36Institute of Molecular Life Sciences and Swiss Institute of Bioinformatics, University of Zurich, CH-8057 Zurich, Switzerland
- 37Department of Genetics, Stanford University School of Medicine, Stanford, California, USA
- 38Department of Haematology, University of Cambridge, Cambridge CB2 2XY, UK
- 39MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, Massachusetts, USA
- 40Department of Computer Science, Princeton University, Princeton, New Jersey 08540, USA
- 41Weill Cornell Medicine and New York Presbyterian, Department of Pathology and Laboratory Medicine, New York, NY, USA
- 42Weill Cornell Medicine and New York Presbyterian, Caryl and Israel Englander Institute for Precision Medicine, New York, NY, USA
- 43Weill Cornell Medicine and New York Presbyterian, Sandra and Edward Meyer Cancer Center, New York, NY, USA
- 44Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada
- 45Center for Biomolecular Science and Engineering, University of California at Santa Cruz, Santa Cruz, CA 95064, USA
- 46Department of Medical Science Mathematics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
- 47Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
- 48CREST, Japan Science and Technology Agency, Tokyo, Japan
- 49Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA
- 50Department of Medical Oncology, Inselspital, University Hospital and University of Bern, 3010 Bern, Switzerland
- 51Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, USA
- 52Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA
- 53Department of Computer Science, Yale University, New Haven, Connecticut, USA
- 54Catalan Institution for Research and Advanced Studies (ICREA), 08010 Barcelona, Spain
- 55Harvard Medical School, 250 Longwood Avenue, Boston, 02115, MA, USA MA, USA
- 56Massachusetts General Hospital, Department of Pathology, Boston, Massachusetts, USA