New Results
Discovery and characterization of coding and non-coding driver mutations in more than 2,500 whole cancer genomes
View ORCID ProfileEsther Rheinbay, View ORCID ProfileMorten Muhlig Nielsen, Federico Abascal, View ORCID ProfileGrace Tiao, Henrik Hornshøj, View ORCID ProfileJulian M. Hess, View ORCID ProfileRandi Istrup Pedersen, View ORCID ProfileLars Feuerbach, View ORCID ProfileRadhakrishnan Sabarinathan, View ORCID ProfileTobias Madsen, View ORCID ProfileJaegil Kim, View ORCID ProfileLoris Mularoni, View ORCID ProfileShimin Shuai, View ORCID ProfileAndrés Lanzós, View ORCID ProfileCarl Herrmann, Yosef E. Maruvka, Ciyue Shen, View ORCID ProfileSamirkumar B. Amin, View ORCID ProfileJohanna Bertl, View ORCID ProfilePriyanka Dhingra, View ORCID ProfileKlev Diamanti, View ORCID ProfileAbel Gonzalez-Perez, View ORCID ProfileQianyun Guo, View ORCID ProfileNicholas J. Haradhvala, Keren Isaev, View ORCID ProfileMalene Juul, View ORCID ProfileJan Komorowski, View ORCID ProfileSushant Kumar, View ORCID ProfileDonghoon Lee, View ORCID ProfileLucas Lochovsky, View ORCID ProfileEric Minwei Liu, View ORCID ProfileOriol Pich, View ORCID ProfileDavid Tamborero, View ORCID ProfileHusen M. Umer, Liis Uusküla-Reimand, View ORCID ProfileClaes Wadelius, Lina Wadi, View ORCID ProfileJing Zhang, View ORCID ProfileKeith A. Boroevich, View ORCID ProfileJoana Carlevaro-Fita, Dimple Chakravarty, View ORCID ProfileCalvin W.Y. Chan, Nuno A. Fonseca, Mark P. Hamilton, Chen Hong, View ORCID ProfileAndre Kahles, Youngwook Kim, View ORCID ProfileKjong-Van Lehmann, View ORCID ProfileTodd A. Johnson, View ORCID ProfileAbdullah Kahraman, Keunchil Park, View ORCID ProfileGordon Saksena, View ORCID ProfileLina Sieverling, View ORCID ProfileNicholas A. Sinnott-Armstrong, Peter J. Campbell, View ORCID ProfileAsger Hobolth, View ORCID ProfileManolis Kellis, Michael S. Lawrence, View ORCID ProfileBen Raphael, View ORCID ProfileMark A. Rubin, Chris Sander, View ORCID ProfileLincoln Stein, Josh Stuart, View ORCID ProfileTatsuhiko Tsunoda, View ORCID ProfileDavid A. Wheeler, View ORCID ProfileRory Johnson, Jüri Reimand, View ORCID ProfileMark B. Gerstein, View ORCID ProfileEkta Khurana, View ORCID ProfileNúria López-Bigas, View ORCID ProfileIñigo Martincorena, View ORCID ProfileJakob Skou Pedersen, View ORCID ProfileGad Getz
doi: https://doi.org/10.1101/237313
Esther Rheinbay
1The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02124, USA
Morten Muhlig Nielsen
2Department of Molecular Medicine (MOMA), Aarhus University Hospital, Aarhus, Denmark
Federico Abascal
3Wellcome Trust Sanger Institute, Hinxton CB10 1SA, Cambridgeshire, UK
Grace Tiao
1The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02124, USA
Henrik Hornshøj
2Department of Molecular Medicine (MOMA), Aarhus University Hospital, Aarhus, Denmark
Julian M. Hess
1The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02124, USA
Randi Istrup Pedersen
2Department of Molecular Medicine (MOMA), Aarhus University Hospital, Aarhus, Denmark
Lars Feuerbach
4Division of Applied Bioinformatics, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany
Radhakrishnan Sabarinathan
5Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac, 10, 08028 Barcelona, Spain
6Research Program on Biomedical Informatics, Universitat Pompeu Fabra, Barcelona, Spain
Tobias Madsen
2Department of Molecular Medicine (MOMA), Aarhus University Hospital, Aarhus, Denmark
Jaegil Kim
1The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02124, USA
Loris Mularoni
5Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac, 10, 08028 Barcelona, Spain
6Research Program on Biomedical Informatics, Universitat Pompeu Fabra, Barcelona, Spain
Shimin Shuai
18Institute for Computational Biomedicine, Weill Cornell Medical College, New York, New York 10021 USA
Andrés Lanzós
8Centre for Genomic Regulation (CRG), Barcelona 08003, Spain
9Universitat Pompeu Fabra (UPF), Barcelona, Spain
Carl Herrmann
10Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
11Institute of Pharmacy and Molecular Biotechnology, and Bioquant Center, University of Heidelberg, 69120 Heidelberg, Germany
Yosef E. Maruvka
1The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02124, USA
12Massachusetts General Hospital, Center for Cancer Research, Charlestown, Massachusetts 02129, USA
Ciyue Shen
13Department of Cell Biology, Harvard Medical School, Boston, MA, USA
14cBio Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston
Samirkumar B. Amin
15Department of Genomic Medicine, the University of Texas MD Anderson Cancer Center, Houston, Texas, USA
16Graduate Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, Texas, USA
Johanna Bertl
2Department of Molecular Medicine (MOMA), Aarhus University Hospital, Aarhus, Denmark
Priyanka Dhingra
17Department of Physiology and Biophysics, Weill Cornell Medicine, 1300 York Avenue, New York, NY, 10065, USA
18Institute for Computational Biomedicine, Weill Cornell Medical College, New York, New York 10021 USA
Klev Diamanti
19Computational Biology and Bioinformatics, Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden
Abel Gonzalez-Perez
5Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac, 10, 08028 Barcelona, Spain
6Research Program on Biomedical Informatics, Universitat Pompeu Fabra, Barcelona, Spain
Qianyun Guo
20Bioinformatics Research Centre (BiRC), Aarhus University, Aarhus, Denmark
Nicholas J. Haradhvala
1The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02124, USA
12Massachusetts General Hospital, Center for Cancer Research, Charlestown, Massachusetts 02129, USA
Keren Isaev
21Computational Biology Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada
22Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
Malene Juul
2Department of Molecular Medicine (MOMA), Aarhus University Hospital, Aarhus, Denmark
Jan Komorowski
19Computational Biology and Bioinformatics, Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden
23Institute of Computer Science, Polish Academy of Sciences, Warsaw, 01-248, Poland
Sushant Kumar
24Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut 06520, USA
Donghoon Lee
24Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut 06520, USA
Lucas Lochovsky
25Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA
Eric Minwei Liu
17Department of Physiology and Biophysics, Weill Cornell Medicine, 1300 York Avenue, New York, NY, 10065, USA
18Institute for Computational Biomedicine, Weill Cornell Medical College, New York, New York 10021 USA
Oriol Pich
5Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac, 10, 08028 Barcelona, Spain
6Research Program on Biomedical Informatics, Universitat Pompeu Fabra, Barcelona, Spain
David Tamborero
5Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac, 10, 08028 Barcelona, Spain
6Research Program on Biomedical Informatics, Universitat Pompeu Fabra, Barcelona, Spain
Husen M. Umer
19Computational Biology and Bioinformatics, Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden
Liis Uusküla-Reimand
26Genetics and Genome Biology Program, SickKids Research Institute, Toronto, ON, Canada
27Department of Gene Technology, Tallinn University of Technology, Estonia
Claes Wadelius
28Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
Lina Wadi
21Computational Biology Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada
Jing Zhang
24Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut 06520, USA
Keith A. Boroevich
29Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
Joana Carlevaro-Fita
8Centre for Genomic Regulation (CRG), Barcelona 08003, Spain
9Universitat Pompeu Fabra (UPF), Barcelona, Spain
Dimple Chakravarty
30Department of Genitourinary Medical Oncology - Research, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Calvin W.Y. Chan
10Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
33Faculty of Biosciences, Heidelberg University, Im Neuenheimer Feld 234, 69120 Heidelberg, Germany
Nuno A. Fonseca
31European Bioinformatics Institute. European Molecular Biology Laboratory. Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, UK
Mark P. Hamilton
32Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza Houston M822, Houston, Texas 77030, USA
Chen Hong
4Division of Applied Bioinformatics, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany
33Faculty of Biosciences, Heidelberg University, Im Neuenheimer Feld 234, 69120 Heidelberg, Germany
Andre Kahles
34Division of Computational Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Youngwook Kim
35Samsung Medical Center, Sungkyunkwan University School of Medicine South Korea
Kjong-Van Lehmann
34Division of Computational Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Todd A. Johnson
29Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
Abdullah Kahraman
36Institute of Molecular Life Sciences and Swiss Institute of Bioinformatics, University of Zurich, CH-8057 Zurich, Switzerland
Keunchil Park
35Samsung Medical Center, Sungkyunkwan University School of Medicine South Korea
Gordon Saksena
1The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02124, USA
Lina Sieverling
4Division of Applied Bioinformatics, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany
33Faculty of Biosciences, Heidelberg University, Im Neuenheimer Feld 234, 69120 Heidelberg, Germany
Nicholas A. Sinnott-Armstrong
37Department of Genetics, Stanford University School of Medicine, Stanford, California, USA
Peter J. Campbell
3Wellcome Trust Sanger Institute, Hinxton CB10 1SA, Cambridgeshire, UK
38Department of Haematology, University of Cambridge, Cambridge CB2 2XY, UK
Asger Hobolth
20Bioinformatics Research Centre (BiRC), Aarhus University, Aarhus, Denmark
Manolis Kellis
1The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02124, USA
39MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, Massachusetts, USA
Michael S. Lawrence
1The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02124, USA
12Massachusetts General Hospital, Center for Cancer Research, Charlestown, Massachusetts 02129, USA
Ben Raphael
40Department of Computer Science, Princeton University, Princeton, New Jersey 08540, USA
Mark A. Rubin
41Weill Cornell Medicine and New York Presbyterian, Department of Pathology and Laboratory Medicine, New York, NY, USA
42Weill Cornell Medicine and New York Presbyterian, Caryl and Israel Englander Institute for Precision Medicine, New York, NY, USA
43Weill Cornell Medicine and New York Presbyterian, Sandra and Edward Meyer Cancer Center, New York, NY, USA
Chris Sander
13Department of Cell Biology, Harvard Medical School, Boston, MA, USA
14cBio Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston
Lincoln Stein
7Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
21Computational Biology Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada
44Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada
Josh Stuart
45Center for Biomolecular Science and Engineering, University of California at Santa Cruz, Santa Cruz, CA 95064, USA
Tatsuhiko Tsunoda
46Department of Medical Science Mathematics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
47Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
48CREST, Japan Science and Technology Agency, Tokyo, Japan
David A. Wheeler
49Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA
Rory Johnson
50Department of Medical Oncology, Inselspital, University Hospital and University of Bern, 3010 Bern, Switzerland
Jüri Reimand
21Computational Biology Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada
22Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
Mark B. Gerstein
51Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, USA
52Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA
53Department of Computer Science, Yale University, New Haven, Connecticut, USA
Ekta Khurana
17Department of Physiology and Biophysics, Weill Cornell Medicine, 1300 York Avenue, New York, NY, 10065, USA
18Institute for Computational Biomedicine, Weill Cornell Medical College, New York, New York 10021 USA
42Weill Cornell Medicine and New York Presbyterian, Caryl and Israel Englander Institute for Precision Medicine, New York, NY, USA
43Weill Cornell Medicine and New York Presbyterian, Sandra and Edward Meyer Cancer Center, New York, NY, USA
Núria López-Bigas
5Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac, 10, 08028 Barcelona, Spain
6Research Program on Biomedical Informatics, Universitat Pompeu Fabra, Barcelona, Spain
54Catalan Institution for Research and Advanced Studies (ICREA), 08010 Barcelona, Spain
Iñigo Martincorena
3Wellcome Trust Sanger Institute, Hinxton CB10 1SA, Cambridgeshire, UK
Jakob Skou Pedersen
2Department of Molecular Medicine (MOMA), Aarhus University Hospital, Aarhus, Denmark
20Bioinformatics Research Centre (BiRC), Aarhus University, Aarhus, Denmark
Gad Getz
1The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02124, USA
12Massachusetts General Hospital, Center for Cancer Research, Charlestown, Massachusetts 02129, USA
55Harvard Medical School, 250 Longwood Avenue, Boston, 02115, MA, USA MA, USA
56Massachusetts General Hospital, Department of Pathology, Boston, Massachusetts, USA
Posted December 23, 2017.
Discovery and characterization of coding and non-coding driver mutations in more than 2,500 whole cancer genomes
Esther Rheinbay, Morten Muhlig Nielsen, Federico Abascal, Grace Tiao, Henrik Hornshøj, Julian M. Hess, Randi Istrup Pedersen, Lars Feuerbach, Radhakrishnan Sabarinathan, Tobias Madsen, Jaegil Kim, Loris Mularoni, Shimin Shuai, Andrés Lanzós, Carl Herrmann, Yosef E. Maruvka, Ciyue Shen, Samirkumar B. Amin, Johanna Bertl, Priyanka Dhingra, Klev Diamanti, Abel Gonzalez-Perez, Qianyun Guo, Nicholas J. Haradhvala, Keren Isaev, Malene Juul, Jan Komorowski, Sushant Kumar, Donghoon Lee, Lucas Lochovsky, Eric Minwei Liu, Oriol Pich, David Tamborero, Husen M. Umer, Liis Uusküla-Reimand, Claes Wadelius, Lina Wadi, Jing Zhang, Keith A. Boroevich, Joana Carlevaro-Fita, Dimple Chakravarty, Calvin W.Y. Chan, Nuno A. Fonseca, Mark P. Hamilton, Chen Hong, Andre Kahles, Youngwook Kim, Kjong-Van Lehmann, Todd A. Johnson, Abdullah Kahraman, Keunchil Park, Gordon Saksena, Lina Sieverling, Nicholas A. Sinnott-Armstrong, Peter J. Campbell, Asger Hobolth, Manolis Kellis, Michael S. Lawrence, Ben Raphael, Mark A. Rubin, Chris Sander, Lincoln Stein, Josh Stuart, Tatsuhiko Tsunoda, David A. Wheeler, Rory Johnson, Jüri Reimand, Mark B. Gerstein, Ekta Khurana, Núria López-Bigas, Iñigo Martincorena, Jakob Skou Pedersen, Gad Getz
bioRxiv 237313; doi: https://doi.org/10.1101/237313
Discovery and characterization of coding and non-coding driver mutations in more than 2,500 whole cancer genomes
Esther Rheinbay, Morten Muhlig Nielsen, Federico Abascal, Grace Tiao, Henrik Hornshøj, Julian M. Hess, Randi Istrup Pedersen, Lars Feuerbach, Radhakrishnan Sabarinathan, Tobias Madsen, Jaegil Kim, Loris Mularoni, Shimin Shuai, Andrés Lanzós, Carl Herrmann, Yosef E. Maruvka, Ciyue Shen, Samirkumar B. Amin, Johanna Bertl, Priyanka Dhingra, Klev Diamanti, Abel Gonzalez-Perez, Qianyun Guo, Nicholas J. Haradhvala, Keren Isaev, Malene Juul, Jan Komorowski, Sushant Kumar, Donghoon Lee, Lucas Lochovsky, Eric Minwei Liu, Oriol Pich, David Tamborero, Husen M. Umer, Liis Uusküla-Reimand, Claes Wadelius, Lina Wadi, Jing Zhang, Keith A. Boroevich, Joana Carlevaro-Fita, Dimple Chakravarty, Calvin W.Y. Chan, Nuno A. Fonseca, Mark P. Hamilton, Chen Hong, Andre Kahles, Youngwook Kim, Kjong-Van Lehmann, Todd A. Johnson, Abdullah Kahraman, Keunchil Park, Gordon Saksena, Lina Sieverling, Nicholas A. Sinnott-Armstrong, Peter J. Campbell, Asger Hobolth, Manolis Kellis, Michael S. Lawrence, Ben Raphael, Mark A. Rubin, Chris Sander, Lincoln Stein, Josh Stuart, Tatsuhiko Tsunoda, David A. Wheeler, Rory Johnson, Jüri Reimand, Mark B. Gerstein, Ekta Khurana, Núria López-Bigas, Iñigo Martincorena, Jakob Skou Pedersen, Gad Getz
bioRxiv 237313; doi: https://doi.org/10.1101/237313
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