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Coadapted genomes and selection on hybrids: Fisher’s geometric model explains a variety of empirical patterns

View ORCID ProfileAlexis Simon, View ORCID ProfileNicolas Bierne, John J. Welch
doi: https://doi.org/10.1101/237925
Alexis Simon
1Institut des Sciences de l’Évolution UMR5554, Université de Montpellier, CNRS-IRD-EPHE-UM, France
2Department of Genetics, University of Cambridge, Downing St. Cambridge, CB23EH, UK
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  • For correspondence: alexis.simon@umontpellier.fr
Nicolas Bierne
1Institut des Sciences de l’Évolution UMR5554, Université de Montpellier, CNRS-IRD-EPHE-UM, France
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John J. Welch
2Department of Genetics, University of Cambridge, Downing St. Cambridge, CB23EH, UK
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Abstract

Natural selection plays a variety of roles in hybridization, speciation and admixture. Most research has focused on two extreme cases: crosses between closely-related inbred lines, where hybrids are fitter than their parents, or crosses between effectively isolated species, where hybrids suffer severe breakdown. Many natural populations must fall into intermediate regimes, with multiple types of gene interaction, but these are more difficult to study. Here, we develop a simple fitness landscape model, and show that it naturally interpolates between previous modeling approaches, involving mildly deleterious recessives, or discrete hybrid incompatibilities. The model yields several new predictions, which we test with genomic data from Mytilus mussels, and published data from plants (Zea, Populus and Senecio) and animals (Mus, Teleogryllus and Drosophila). The predictions are generally supported, and the model explains surprising empirical patterns that have been observed in both extreme regimes. Our approach enables novel and complementary uses of genome-wide datasets, which do not depend on identifying outlier loci, or “speciation genes” with anomalous effects. Given its simplicity and flexibility, and its predictive successes with a wide range of data, the approach should be readily extendable to other outstanding questions in the study of hybridization.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted March 05, 2018.
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Coadapted genomes and selection on hybrids: Fisher’s geometric model explains a variety of empirical patterns
Alexis Simon, Nicolas Bierne, John J. Welch
bioRxiv 237925; doi: https://doi.org/10.1101/237925
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Coadapted genomes and selection on hybrids: Fisher’s geometric model explains a variety of empirical patterns
Alexis Simon, Nicolas Bierne, John J. Welch
bioRxiv 237925; doi: https://doi.org/10.1101/237925

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