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Contact-dependent cell-cell communications drive morphological invariance during ascidian embryogenesis

View ORCID ProfileLéo Guignard, Ulla-Maj Fiuza, Bruno Leggio, View ORCID ProfileEmmanuel Faure, Julien Laussu, Lars Hufnagel, View ORCID ProfileGrégoire Malandain, View ORCID ProfileChristophe Godin, View ORCID ProfilePatrick Lemaire
doi: https://doi.org/10.1101/238741
Léo Guignard
1CRBM, Université de Montpellier, France
2Inria project-team Virtual Plants, CIRAD, INRA, Université de Montpellier, France
3Janelia Research Campus, Howard Hughes Medical Institute, 19700 Helix drive, Ashburn, VA, USA
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Ulla-Maj Fiuza
1CRBM, Université de Montpellier, France
4European Molecular Biology Laboratory, Cell Biology and Biophysics Unit, Meyerhofstrasse 1, 69117, Heidelberg, Germany
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Bruno Leggio
1CRBM, Université de Montpellier, France
2Inria project-team Virtual Plants, CIRAD, INRA, Université de Montpellier, France
5Institut de Biologie Computationnelle, IBC, Université de Montpellier, France
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Emmanuel Faure
1CRBM, Université de Montpellier, France
2Inria project-team Virtual Plants, CIRAD, INRA, Université de Montpellier, France
5Institut de Biologie Computationnelle, IBC, Université de Montpellier, France
6IRIT, CNRS, INPT, ENSEEIHT, Universités de Toulouse I et III, France
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Julien Laussu
1CRBM, Université de Montpellier, France
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Lars Hufnagel
4European Molecular Biology Laboratory, Cell Biology and Biophysics Unit, Meyerhofstrasse 1, 69117, Heidelberg, Germany
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Grégoire Malandain
7Université Côte d’Azur, Inria, CNRS, I3S, France
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Christophe Godin
2Inria project-team Virtual Plants, CIRAD, INRA, Université de Montpellier, France
5Institut de Biologie Computationnelle, IBC, Université de Montpellier, France
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Patrick Lemaire
1CRBM, Université de Montpellier, France
5Institut de Biologie Computationnelle, IBC, Université de Montpellier, France
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ABSTRACT

Canalization of developmental processes ensures the reproducibility and robustness of embryogenesis within each species. In its extreme form, found in ascidians, early embryonic cell lineages are invariant between embryos within and between species, despite rapid genomic divergence. To resolve this paradox, we used live light-sheet imaging to quantify individual cell behaviors in digitalized embryos and explore the forces that canalize their development. This quantitative approach revealed that individual cell geometries and cell contacts are strongly constrained, and that these constraints are tightly linked to the control of fate specification by local cell inductions. While in vertebrates ligand concentration usually controls cell inductions, we found that this role is fulfilled in ascidians by the area of contacts between signaling and responding cells. We propose that the duality between geometric and genetic control of inductions contributes to the counterintuitive inverse correlation between geometric and genetic variability during embryogenesis.

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Posted February 22, 2018.
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Contact-dependent cell-cell communications drive morphological invariance during ascidian embryogenesis
Léo Guignard, Ulla-Maj Fiuza, Bruno Leggio, Emmanuel Faure, Julien Laussu, Lars Hufnagel, Grégoire Malandain, Christophe Godin, Patrick Lemaire
bioRxiv 238741; doi: https://doi.org/10.1101/238741
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Contact-dependent cell-cell communications drive morphological invariance during ascidian embryogenesis
Léo Guignard, Ulla-Maj Fiuza, Bruno Leggio, Emmanuel Faure, Julien Laussu, Lars Hufnagel, Grégoire Malandain, Christophe Godin, Patrick Lemaire
bioRxiv 238741; doi: https://doi.org/10.1101/238741

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