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Association of Peripheral Blood Pressure with Grey Matter Volume in 19- to 40-Year-Old Adults

H. Lina Schaare, Shahrzad Kharabian Masouleh, Frauke Beyer, Deniz Kumral, Marie Uhlig, Janis D. Reinelt, Andrea M.F. Reiter, Leonie Lampe, Anahit Babayan, Miray Erbey, Josefin Roebbig, Matthias L. Schroeter, Hadas Okon-Singer, Karsten Müller, Natacha Mendes, Daniel S. Margulies, A. Veronica Witte, Michael Gaebler, Arno Villringer
doi: https://doi.org/10.1101/239160
H. Lina Schaare
Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, GermanyInternational Max Planck Research School NeuroCom, Leipzig, Germany
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Shahrzad Kharabian Masouleh
Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
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Frauke Beyer
Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, GermanyCollaborative Research Centre 1052 ‘Obesity Mechanisms’, Subproject A1, Faculty of Medicine, University of Leipzig, Germany
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Deniz Kumral
Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, GermanyMindBrainBody Institute at Berlin School of Mind and Brain, Charité & Humboldt Universität zu Berlin, Germany
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Marie Uhlig
Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, GermanyInternational Max Planck Research School NeuroCom, Leipzig, Germany
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Janis D. Reinelt
Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
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Andrea M.F. Reiter
Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, GermanyLifespan Developmental Neuroscience, Technische Universität Dresden, Germany
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Leonie Lampe
Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
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Anahit Babayan
Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, GermanyMindBrainBody Institute at Berlin School of Mind and Brain, Charité & Humboldt Universität zu Berlin, Germany
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Miray Erbey
Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, GermanyMindBrainBody Institute at Berlin School of Mind and Brain, Charité & Humboldt Universität zu Berlin, Germany
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Josefin Roebbig
Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
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Matthias L. Schroeter
Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, GermanyLeipzig Research Centre for Civilization Diseases (LIFE), University of Leipzig, GermanyClinic for Cognitive Neurology, University of Leipzig, Germany
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Hadas Okon-Singer
Department of Psychology, University of Haifa, Israel
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Karsten Müller
Nuclear Magnetic Resonance Group, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
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Natacha Mendes
Max Planck Research Group for Neuroanatomy & Connectivity, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
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Daniel S. Margulies
Max Planck Research Group for Neuroanatomy & Connectivity, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
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A. Veronica Witte
Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, GermanyCollaborative Research Centre 1052 ‘Obesity Mechanisms’, Subproject A1, Faculty of Medicine, University of Leipzig, Germany
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Michael Gaebler
Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, GermanyMindBrainBody Institute at Berlin School of Mind and Brain, Charité & Humboldt Universität zu Berlin, GermanyLeipzig Research Centre for Civilization Diseases (LIFE), University of Leipzig, Germany
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Arno Villringer
Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, GermanyMindBrainBody Institute at Berlin School of Mind and Brain, Charité & Humboldt Universität zu Berlin, GermanyLeipzig Research Centre for Civilization Diseases (LIFE), University of Leipzig, GermanyClinic for Cognitive Neurology, University of Leipzig, GermanyCollaborative Research Centre 1052 ‘Obesity Mechanisms’, Subproject A1, Faculty of Medicine, University of Leipzig, GermanyCenter for Stroke Research Berlin, Charité – Universitätsmedizin Berlin, Germany
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Abstract

Objective To test whether elevated blood pressure (BP) relates to grey matter volume (GMV) changes in young adults who had not previously been diagnosed as hypertensive (systolic BP (SBP)/diastolic BP (DBP)≥140/90 mmHg).

Methods We associated BP with GMV from structural 3 Tesla T1-weighted MRI of 423 healthy adults between 19-40 years (mean age=27.7±5.3 years, 177 women, SBP/DBP=123.2/73.4±12.2/8.5 mmHg). Data originated from four previously unpublished cross-sectional studies conducted in Leipzig, Germany. We performed voxel-based morphometry on each study separately and combined results in image-based meta-analyses (IBMA) to assess cumulative effects across studies. Resting BP was assigned to one of four categories: (1) SBP<120 and DBP<80 mmHg, (2) SBP 120-129 or DBP 80-84 mmHg, (3) SBP 130-139 or DBP 85-89 mmHg, (4) SBP≥140 or DBP≥90 mmHg.

Results IBMA yielded: (a) lower regional GMV was correlated with higher peripheral BP; (b) lower GMV with higher BP when comparing individuals in sub-hypertensive categories 3 and 2, respectively, to those in category 1; (c) lower BP-related GMV was found in regions including hippocampus, amygdala, thalamus, frontal and parietal structures (e.g. precuneus).

Conclusions BP≥120/80 mmHg was associated with lower GMV in regions that have previously been related to GM decline in older individuals with manifest hypertension. Our study shows that BP-associated GM alterations emerge continuously across the range of BP and earlier in adulthood than previously assumed. This suggests that treating hypertension or maintaining lower BP in early adulthood might be essential for preventing the pathophysiological cascade of asymptomatic cerebrovascular disease to symptomatic end-organ damage, such as stroke or dementia.

Author contributions

Study concept and design: Schaare, Villringer.

Statistical analysis: Schaare.

Acquisition or interpretation of data: All authors.

Drafting of the manuscript: Schaare, Villringer.

Critical revision of the manuscript: All authors.

Acknowledgements

We thank all volunteers for their participation in any of the studies. Furthermore, we thank all researchers, technicians and students who planned, collected, entered and curated data used in this manuscript.

Footnotes

  • Statistical analysis

    Statistical analysis conducted by H. Lina Schaare, Max Planck Institute for Human Cognitive and Brain Sciences

  • Study funding

    Max Planck Institute for Human Cognitive and Brain Sciences

  • Disclosures

    • Ms. Schaare reports no disclosures.

    • Ms. Kharabian Masouleh reports no disclosures.

    • Ms. Beyer reports no disclosures.

    • Ms. Kumral reports no disclosures.

    • Ms. Uhlig reports no disclosures.

    • Mr. Reinelt reports no disclosures.

    • Dr. Reiter reports no disclosures.

    • Dr. Lampe reports no disclosures.

    • Dr. Babayan reports no disclosures.

    • Ms. Erbey reports no disclosures.

    • Ms. Roebbig reports no disclosures.

    • Dr. Schroeter reports no disclosures.

    • Dr. Okon-Singer reports no disclosures.

    • Dr. Müller reports no disclosures.

    • Dr. Mendes reports no disclosures.

    • Dr. Margulies reports no disclosures.

    • Dr. Witte reports no disclosures.

    • Dr. Gaebler reports no disclosures.

    • Dr. Villringer reports no disclosures.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted September 10, 2018.
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Association of Peripheral Blood Pressure with Grey Matter Volume in 19- to 40-Year-Old Adults
H. Lina Schaare, Shahrzad Kharabian Masouleh, Frauke Beyer, Deniz Kumral, Marie Uhlig, Janis D. Reinelt, Andrea M.F. Reiter, Leonie Lampe, Anahit Babayan, Miray Erbey, Josefin Roebbig, Matthias L. Schroeter, Hadas Okon-Singer, Karsten Müller, Natacha Mendes, Daniel S. Margulies, A. Veronica Witte, Michael Gaebler, Arno Villringer
bioRxiv 239160; doi: https://doi.org/10.1101/239160
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Association of Peripheral Blood Pressure with Grey Matter Volume in 19- to 40-Year-Old Adults
H. Lina Schaare, Shahrzad Kharabian Masouleh, Frauke Beyer, Deniz Kumral, Marie Uhlig, Janis D. Reinelt, Andrea M.F. Reiter, Leonie Lampe, Anahit Babayan, Miray Erbey, Josefin Roebbig, Matthias L. Schroeter, Hadas Okon-Singer, Karsten Müller, Natacha Mendes, Daniel S. Margulies, A. Veronica Witte, Michael Gaebler, Arno Villringer
bioRxiv 239160; doi: https://doi.org/10.1101/239160

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