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Chromatin interaction data visualization in the WashU Epigenome Browser

Daofeng Li, Silas Hsu, Deepak Purushotham, Ting Wang
doi: https://doi.org/10.1101/239368
Daofeng Li
Department of Genetics, Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA
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Silas Hsu
Department of Genetics, Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA
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Deepak Purushotham
Department of Genetics, Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA
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Ting Wang
Department of Genetics, Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA
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Abstract

Motivation Long-range chromatin interactions are critical for gene regulations and genome maintenance. HiC and Cool are the two most common data formats used by the community, including the 4D Nucleome Consortium (4DN), to represent chromatin interaction data from a variety of chromatin conformation capture experiments, and specialized tools were developed for their analysis, visualization, and conversion. However, there does not exist a tool that can support visualization of both data formats simultaneously.

Results The WashU Epigenome Browser has integrated both HiC and Cool data formats into its visualization platform. Investigators can seamlessly explore chromatin interaction data regardless of their underlying data format. For developers it is straightforward to benchmark the differences in rendering speed and computational resource usage between the two data formats.

Availability http://epigenomegateway.wustl.edu/browser/.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted December 24, 2017.
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Chromatin interaction data visualization in the WashU Epigenome Browser
Daofeng Li, Silas Hsu, Deepak Purushotham, Ting Wang
bioRxiv 239368; doi: https://doi.org/10.1101/239368
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Chromatin interaction data visualization in the WashU Epigenome Browser
Daofeng Li, Silas Hsu, Deepak Purushotham, Ting Wang
bioRxiv 239368; doi: https://doi.org/10.1101/239368

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