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Genome-wide association study of 1 million people identifies 111 loci for atrial fibrillation
View ORCID ProfileJonas B. Nielsen, Rosa B. Thorolfsdottir, View ORCID ProfileLars G. Fritsche, View ORCID ProfileWei Zhou, Morten W. Skov, Sarah E. Graham, Todd J. Herron, Shane McCarthy, Ellen M. Schmidt, Gardar Sveinbjornsson, Ida Surakka, Michael R. Mathis, Masatoshi Yamazaki, Ryan D. Crawford, Maiken E. Gabrielsen, Anne Heidi Skogholt, Oddgeir L. Holmen, Maoxuan Lin, View ORCID ProfileBrooke N. Wolford, Rounak Dey, Håvard Dalen, Patrick Sulem, Jonathan H. Chung, Joshua D. Backman, David O. Arnar, Unnur Thorsteinsdottir, Aris Baras, Colm O’Dushlaine, Anders G. Holst, Xiaoquan Wen, Whitney Hornsby, Frederick E. Dewey, Michael Boehnke, Sachin Kheterpal, View ORCID ProfileSeunggeun Lee, Hyun M. Kang, Hilma Holm, Jacob Kitzman, Jordan A. Shavit, José Jalife, Chad M. Brummett, Tanya M. Teslovich, David J. Carey, Daniel F. Gudbjartsson, Kari Stefansson, Goncalo R. Abecasis, Kristian Hveem, View ORCID ProfileCristen J. Willer
doi: https://doi.org/10.1101/242149
Jonas B. Nielsen
1Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, United States.
2Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, United States.
Rosa B. Thorolfsdottir
3deCODE genetics/Amgen, Inc., Reykjavik, Iceland.
Lars G. Fritsche
1Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, United States.
4HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.
5K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health, Norwegian University of Science and Technology, Trondheim, Norway.
6Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States.
Wei Zhou
1Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, United States.
6Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States.
Morten W. Skov
7Laboratory of Molecular Cardiology, Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Sarah E. Graham
1Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, United States.
2Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, United States.
Todd J. Herron
8Department of Internal Medicine, Center for Arrhythmia Research, University of Michigan, Ann Arbor, Michigan, United States.
Shane McCarthy
9Regeneron Genetics Center, Tarrytown, NY, United States.
Ellen M. Schmidt
10Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States.
Gardar Sveinbjornsson
3deCODE genetics/Amgen, Inc., Reykjavik, Iceland.
Ida Surakka
1Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, United States.
2Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, United States.
Michael R. Mathis
11Department of Anesthesiology, University of Michigan, Ann Arbor, Michigan
Masatoshi Yamazaki
12Medical Device Development and Regulation Research Center, The University of Tokyo, Japan.
Ryan D. Crawford
6Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States.
Maiken E. Gabrielsen
4HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.
5K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health, Norwegian University of Science and Technology, Trondheim, Norway.
Anne Heidi Skogholt
4HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.
5K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health, Norwegian University of Science and Technology, Trondheim, Norway.
Oddgeir L. Holmen
4HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.
5K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health, Norwegian University of Science and Technology, Trondheim, Norway.
13Department of Cardiology, St. Olav’s University Hospital, Trondheim, Norway.
Maoxuan Lin
1Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, United States.
2Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, United States.
Brooke N. Wolford
1Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, United States.
6Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States.
Rounak Dey
10Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States.
Håvard Dalen
14Department of Medicine, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway.
15Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway.
16Department of Cardiology, St. Olav’s University Hospital, Trondheim University Hospital, Norway.
Patrick Sulem
3deCODE genetics/Amgen, Inc., Reykjavik, Iceland.
Jonathan H. Chung
9Regeneron Genetics Center, Tarrytown, NY, United States.
Joshua D. Backman
9Regeneron Genetics Center, Tarrytown, NY, United States.
David O. Arnar
17Faculty of Medicine, University of Iceland, Reykjavik, Iceland
18Department of Medicine, Landspitali - National University Hospital, Reykjavik, Iceland
Unnur Thorsteinsdottir
3deCODE genetics/Amgen, Inc., Reykjavik, Iceland.
17Faculty of Medicine, University of Iceland, Reykjavik, Iceland
Aris Baras
9Regeneron Genetics Center, Tarrytown, NY, United States.
Colm O’Dushlaine
9Regeneron Genetics Center, Tarrytown, NY, United States.
Anders G. Holst
7Laboratory of Molecular Cardiology, Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Xiaoquan Wen
10Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States.
Whitney Hornsby
1Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, United States.
Frederick E. Dewey
9Regeneron Genetics Center, Tarrytown, NY, United States.
Michael Boehnke
10Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States.
Sachin Kheterpal
11Department of Anesthesiology, University of Michigan, Ann Arbor, Michigan
Seunggeun Lee
10Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States.
Hyun M. Kang
10Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States.
Hilma Holm
3deCODE genetics/Amgen, Inc., Reykjavik, Iceland.
Jacob Kitzman
2Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, United States.
Jordan A. Shavit
20Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI
José Jalife
1Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, United States.
8Department of Internal Medicine, Center for Arrhythmia Research, University of Michigan, Ann Arbor, Michigan, United States.
21Fundación Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid and CIBERCV, Spain.
Chad M. Brummett
11Department of Anesthesiology, University of Michigan, Ann Arbor, Michigan
Tanya M. Teslovich
9Regeneron Genetics Center, Tarrytown, NY, United States.
David J. Carey
22Geisinger Health System, Danville, PA 17822, USA.
Daniel F. Gudbjartsson
3deCODE genetics/Amgen, Inc., Reykjavik, Iceland.
19School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland.
Kari Stefansson
3deCODE genetics/Amgen, Inc., Reykjavik, Iceland.
17Faculty of Medicine, University of Iceland, Reykjavik, Iceland
Goncalo R. Abecasis
5K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health, Norwegian University of Science and Technology, Trondheim, Norway.
10Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States.
Kristian Hveem
4HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.
5K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health, Norwegian University of Science and Technology, Trondheim, Norway.
14Department of Medicine, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway.
Cristen J. Willer
1Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, United States.
2Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, United States.
6Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States.
Article usage
Posted January 04, 2018.
Genome-wide association study of 1 million people identifies 111 loci for atrial fibrillation
Jonas B. Nielsen, Rosa B. Thorolfsdottir, Lars G. Fritsche, Wei Zhou, Morten W. Skov, Sarah E. Graham, Todd J. Herron, Shane McCarthy, Ellen M. Schmidt, Gardar Sveinbjornsson, Ida Surakka, Michael R. Mathis, Masatoshi Yamazaki, Ryan D. Crawford, Maiken E. Gabrielsen, Anne Heidi Skogholt, Oddgeir L. Holmen, Maoxuan Lin, Brooke N. Wolford, Rounak Dey, Håvard Dalen, Patrick Sulem, Jonathan H. Chung, Joshua D. Backman, David O. Arnar, Unnur Thorsteinsdottir, Aris Baras, Colm O’Dushlaine, Anders G. Holst, Xiaoquan Wen, Whitney Hornsby, Frederick E. Dewey, Michael Boehnke, Sachin Kheterpal, Seunggeun Lee, Hyun M. Kang, Hilma Holm, Jacob Kitzman, Jordan A. Shavit, José Jalife, Chad M. Brummett, Tanya M. Teslovich, David J. Carey, Daniel F. Gudbjartsson, Kari Stefansson, Goncalo R. Abecasis, Kristian Hveem, Cristen J. Willer
bioRxiv 242149; doi: https://doi.org/10.1101/242149
Genome-wide association study of 1 million people identifies 111 loci for atrial fibrillation
Jonas B. Nielsen, Rosa B. Thorolfsdottir, Lars G. Fritsche, Wei Zhou, Morten W. Skov, Sarah E. Graham, Todd J. Herron, Shane McCarthy, Ellen M. Schmidt, Gardar Sveinbjornsson, Ida Surakka, Michael R. Mathis, Masatoshi Yamazaki, Ryan D. Crawford, Maiken E. Gabrielsen, Anne Heidi Skogholt, Oddgeir L. Holmen, Maoxuan Lin, Brooke N. Wolford, Rounak Dey, Håvard Dalen, Patrick Sulem, Jonathan H. Chung, Joshua D. Backman, David O. Arnar, Unnur Thorsteinsdottir, Aris Baras, Colm O’Dushlaine, Anders G. Holst, Xiaoquan Wen, Whitney Hornsby, Frederick E. Dewey, Michael Boehnke, Sachin Kheterpal, Seunggeun Lee, Hyun M. Kang, Hilma Holm, Jacob Kitzman, Jordan A. Shavit, José Jalife, Chad M. Brummett, Tanya M. Teslovich, David J. Carey, Daniel F. Gudbjartsson, Kari Stefansson, Goncalo R. Abecasis, Kristian Hveem, Cristen J. Willer
bioRxiv 242149; doi: https://doi.org/10.1101/242149
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