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The Homeostatic Logic of Reward

View ORCID ProfileTobias Morville, View ORCID ProfileKarl Friston, View ORCID ProfileDenis Burdakov, View ORCID ProfileHartwig R. Siebner, View ORCID ProfileOliver J. Hulme
doi: https://doi.org/10.1101/242974
Tobias Morville
1Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Kettegard Allé 30, 2650, Hvidovre, Denmark
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Karl Friston
2The Wellcome Trust Centre for Neuroimaging, University College London, 12 Queen Square, London, WC1N 3BG UK
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Denis Burdakov
3The Francis Crick Institute, Mill Hill Laboratory, London, NW7 1AA, UK
4Institute of Psychiatry, Psychology and Neuroscience, Department of Developmental Neurobiology, King’s College London, London WC2R 2LS, UK
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Hartwig R. Siebner
1Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Kettegard Allé 30, 2650, Hvidovre, Denmark
5Department of Neurology, Copenhagen University Hospital Bispebjerg, Copenhagen, 2400, Denmark
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Oliver J. Hulme
1Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Kettegard Allé 30, 2650, Hvidovre, Denmark
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  • For correspondence: oliverh@drcmr.dk
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Abstract

Energy homeostasis depends on behavior to predictively regulate metabolic states within narrow bounds. Here we review three theories of homeostatic control and ask how they provide insight into the circuitry underlying energy homeostasis. We offer two contributions. First, we detail how control theory and reinforcement learning are applied to homeostatic control. We show how these schemes rest on implausible assumptions; either via circular definitions, unprincipled drive functions, or by ignoring environmental volatility. We argue active inference can elude these shortcomings while retaining important features of each model. Second, we review the neural basis of energetic control. We focus on a subset of arcuate subpopulations that project directly to, and are thus in a privileged position to opponently modulate, dopaminergic cells as a function of energetic predictions over a spectrum of time horizons. We discuss how this can be interpreted under these theories, and how this can resolve paradoxes that have arisen. We propose this circuit constitutes a homeostatic-reward interface that underwrites the conjoint optimisation of physiological and behavioural homeostasis.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted January 05, 2018.
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The Homeostatic Logic of Reward
Tobias Morville, Karl Friston, Denis Burdakov, Hartwig R. Siebner, Oliver J. Hulme
bioRxiv 242974; doi: https://doi.org/10.1101/242974
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The Homeostatic Logic of Reward
Tobias Morville, Karl Friston, Denis Burdakov, Hartwig R. Siebner, Oliver J. Hulme
bioRxiv 242974; doi: https://doi.org/10.1101/242974

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