Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Malaria during pregnancy and newborns outcome in an unstable transmission area in Brazil: a population-based record linkage study

Jamille Gregório Dombrowski, Rodrigo Medeiros de Souza, Natércia Regina Mendes Silva, André Barateiro, Sabrina Epiphanio, Lígia Antunes Gonçalves, View ORCID ProfileCláudio Romero Farias Marinho
doi: https://doi.org/10.1101/244178
Jamille Gregório Dombrowski
aDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil
BSc
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Rodrigo Medeiros de Souza
bMultidisciplinary Center, Federal University of Acre, Acre, Brazil
PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Natércia Regina Mendes Silva
aDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil
BSc
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
André Barateiro
aDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil
MSc
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sabrina Epiphanio
cDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil
PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lígia Antunes Gonçalves
aDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil
PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: marinho@usp.br lig.antunes.goncalves@gmail.com
Cláudio Romero Farias Marinho
aDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil
PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Cláudio Romero Farias Marinho
  • For correspondence: marinho@usp.br lig.antunes.goncalves@gmail.com
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

ABSTRACT

Background Malaria during pregnancy is one of the major causes of mortality in tropical regions, causing maternal anemia, intrauterine growth retardation, preterm birth, and low birth weight (LBW). The integration of the information systems is crucial to assess the dimension of gestational malaria in a wide and useful way, to improve decision making and maternal-child health.

Methods and Findings An observational population-based study acquired information retrospectively from all live births that occurred between 2006 and 2014 in Cruzeiro do Sul (Acre, Brazil). Social and clinical data of the mother and newborn was extracted from the Information System of Live Births. Malaria episodes information was obtained from the Brazilian Epidemiological Surveillance Information System Malaria. A deterministic record linkage was performed to assess malaria impact on pregnancy. The studied population presented a malaria incidence of 8.9%, of which 63.9% infected by Plasmodium (P.) vivax. Reduction of newborns birth weight at term (small for gestational age (SGA) and LBW) has been found associated with P. vivax infection during pregnancy (SGA - OR 1.24, 95% CI 1.02-1.52, p=0.035; term LBW - OR 1.39, 95% CI 1.03-1.88, p=0.033). Additionally, P. falciparum infection during pregnancy has been found to be associated with preterm births (OR 1.54, 95% CI 1.09-2.18, p=0.016), which is related with late preterm births (OR 1.59, 95% CI 1.11-2.27, p=0.011).

Conclusions Despite the decrease of malaria cases during the evaluated period, we present evidence of the deleterious effects of gestational malaria in a low transmission area in the Amazonian region. Regardless of Plasmodium species, malaria during pregnancy poses a risk for newborns birth weight reduction, highlighting the impact that P. vivax has on the fetus.

Funding São Paulo Research Foundation - FAPESP/Brazil.

Footnotes

  • ↵# These authors are joint senior authors on this work.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted January 08, 2018.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Malaria during pregnancy and newborns outcome in an unstable transmission area in Brazil: a population-based record linkage study
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Malaria during pregnancy and newborns outcome in an unstable transmission area in Brazil: a population-based record linkage study
Jamille Gregório Dombrowski, Rodrigo Medeiros de Souza, Natércia Regina Mendes Silva, André Barateiro, Sabrina Epiphanio, Lígia Antunes Gonçalves, Cláudio Romero Farias Marinho
bioRxiv 244178; doi: https://doi.org/10.1101/244178
Reddit logo Twitter logo Facebook logo LinkedIn logo Mendeley logo
Citation Tools
Malaria during pregnancy and newborns outcome in an unstable transmission area in Brazil: a population-based record linkage study
Jamille Gregório Dombrowski, Rodrigo Medeiros de Souza, Natércia Regina Mendes Silva, André Barateiro, Sabrina Epiphanio, Lígia Antunes Gonçalves, Cláudio Romero Farias Marinho
bioRxiv 244178; doi: https://doi.org/10.1101/244178

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Epidemiology
Subject Areas
All Articles
  • Animal Behavior and Cognition (4654)
  • Biochemistry (10299)
  • Bioengineering (7614)
  • Bioinformatics (26189)
  • Biophysics (13446)
  • Cancer Biology (10620)
  • Cell Biology (15333)
  • Clinical Trials (138)
  • Developmental Biology (8452)
  • Ecology (12754)
  • Epidemiology (2067)
  • Evolutionary Biology (16763)
  • Genetics (11356)
  • Genomics (15400)
  • Immunology (10548)
  • Microbiology (25041)
  • Molecular Biology (10152)
  • Neuroscience (54096)
  • Paleontology (398)
  • Pathology (1655)
  • Pharmacology and Toxicology (2877)
  • Physiology (4314)
  • Plant Biology (9196)
  • Scientific Communication and Education (1579)
  • Synthetic Biology (2541)
  • Systems Biology (6752)
  • Zoology (1452)