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Manipulation of central amygdala neurotensin neurons alters alcohol consumption

María Luisa Torruella-Súarez, Jessica R. Vandenberg, Gregory J. Tipton, Brennon R. Luster, Kedar Dange, Gunjan K. Patel, Jenna A. McHenry, J. Andrew Hardaway, Pranish A. Kantak, Nicole A. Crowley, Jeffrey F. DiBerto, Sara P. Faccidomo, Clyde W. Hodge, Garret D. Stuber, Zoé A. McElligott
doi: https://doi.org/10.1101/245274
María Luisa Torruella-Súarez
1Neuroscience Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599
2Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599
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Jessica R. Vandenberg
2Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599
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Gregory J. Tipton
2Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599
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Brennon R. Luster
2Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599
3Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599
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Kedar Dange
2Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599
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Gunjan K. Patel
2Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599
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Jenna A. McHenry
3Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599
4Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599
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J. Andrew Hardaway
2Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599
5Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599
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Pranish A. Kantak
3Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599
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Nicole A. Crowley
1Neuroscience Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599
2Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599
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Jeffrey F. DiBerto
2Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599
5Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599
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Sara P. Faccidomo
2Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599
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Clyde W. Hodge
2Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599
3Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599
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Garret D. Stuber
2Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599
3Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599
4Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599
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Zoé A. McElligott
2Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599
3Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599
4Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599
5Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27599
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  • For correspondence: zoemce@email.unc.edu
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Abstract

The central nucleus of the amygdala plays a significant role in alcohol use and other affective disorders; however, the genetically-defined neuronal subtypes and their projections that govern these behaviors are not well known. Here we show that ablation of neurotensin-expressing neurons in the central nucleus of the amygdala of mice decreases their ethanol consumption and preference for ethanol. Furthermore, optogenetically stimulating projections from these neurons to the parabrachial nucleus is reinforcing, and increases ethanol consumption while reducing food consumption. These data suggest that this central amygdala to parabrachial nucleus projection influences the expression of reward-related phenotypes and is a novel circuit promoting alcohol consumption and regulating state-dependent food consumption.

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Posted January 09, 2018.
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Manipulation of central amygdala neurotensin neurons alters alcohol consumption
María Luisa Torruella-Súarez, Jessica R. Vandenberg, Gregory J. Tipton, Brennon R. Luster, Kedar Dange, Gunjan K. Patel, Jenna A. McHenry, J. Andrew Hardaway, Pranish A. Kantak, Nicole A. Crowley, Jeffrey F. DiBerto, Sara P. Faccidomo, Clyde W. Hodge, Garret D. Stuber, Zoé A. McElligott
bioRxiv 245274; doi: https://doi.org/10.1101/245274
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Manipulation of central amygdala neurotensin neurons alters alcohol consumption
María Luisa Torruella-Súarez, Jessica R. Vandenberg, Gregory J. Tipton, Brennon R. Luster, Kedar Dange, Gunjan K. Patel, Jenna A. McHenry, J. Andrew Hardaway, Pranish A. Kantak, Nicole A. Crowley, Jeffrey F. DiBerto, Sara P. Faccidomo, Clyde W. Hodge, Garret D. Stuber, Zoé A. McElligott
bioRxiv 245274; doi: https://doi.org/10.1101/245274

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