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Causal contribution and dynamical encoding in the striatum during evidence accumulation

Michael M. Yartsev, Timothy D. Hanks, Alice M. Yoon, Carlos D. Brody
doi: https://doi.org/10.1101/245316
Michael M. Yartsev
1Princeton Neuroscience Institute, Princeton, NJ.
2Department of Bioengineering and the Helen Wills Neuroscience Institute, UC Berkeley, CA
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  • For correspondence: myartsev@berkeley.edu thanks@ucdavis.edu brody@princeton.edu
Timothy D. Hanks
1Princeton Neuroscience Institute, Princeton, NJ.
3Department of Neurology and Center for Neuroscience, UC Davis, CA
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  • For correspondence: myartsev@berkeley.edu thanks@ucdavis.edu brody@princeton.edu
Alice M. Yoon
1Princeton Neuroscience Institute, Princeton, NJ.
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Carlos D. Brody
1Princeton Neuroscience Institute, Princeton, NJ.
4HHMI
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  • For correspondence: myartsev@berkeley.edu thanks@ucdavis.edu brody@princeton.edu
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Abstract

A broad range of decision-making processes involve gradual accumulation of evidence over time, but the neural circuits responsible for this computation are not yet established. Recent data indicates that cortical regions prominently associated with accumulating evidence, such as posterior parietal cortex and the frontal orienting fields, are not necessary for computing it. Which, then, are the regions responsible? Regions directly involved in evidence accumulation should satisfy the criteria of being necessary for accumulation-based decision-making behavior, having a graded neural encoding of accumulated evidence and causal contributing throughout the accumulation process. Here, we investigated the role of the anterior dorsal striatum (ADS) in a rodent auditory evidence accumulation task using a combination of behavioral, pharmacological, optogenetic, electrophysiological and computational approaches. We find that the ADS is the first brain region known to satisfy these criteria. Thus, the ADS may be the first identified node in the network responsible for evidence accumulation.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted January 10, 2018.
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Causal contribution and dynamical encoding in the striatum during evidence accumulation
Michael M. Yartsev, Timothy D. Hanks, Alice M. Yoon, Carlos D. Brody
bioRxiv 245316; doi: https://doi.org/10.1101/245316
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Causal contribution and dynamical encoding in the striatum during evidence accumulation
Michael M. Yartsev, Timothy D. Hanks, Alice M. Yoon, Carlos D. Brody
bioRxiv 245316; doi: https://doi.org/10.1101/245316

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