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Characterization of P. falciparum dipeptidyl aminopeptidase 3 specificity reveals structural factors responsible for differences in amino acid preferences between peptide-based substrates and covalent inhibitors
Laura E. de Vries, Mateo I. Sanchez, Katarzyna Groborz, Laurie Kuppens, Marcin Poreba, Christine Lehmann, Fang Yuan, Shirin Arastu-Kapur, Martin Horn, Michael Mares, Matthew Bogyo, Marcin Drag, Edgar Deu
doi: https://doi.org/10.1101/246124
Laura E. de Vries
1Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands
Mateo I. Sanchez
2Department of Genetics, Stanford School of Medicine, Stanford, California, United States
Katarzyna Groborz
3Division of Bioorganic Chemistry, Faculty of Chemistry, Wroclaw University of Technology, Wroclaw, Poland
Laurie Kuppens
4Chemical Biology Approaches to Malaria Laboratory, The Francis Crick Institute, London, England, United Kingdom
Marcin Poreba
3Division of Bioorganic Chemistry, Faculty of Chemistry, Wroclaw University of Technology, Wroclaw, Poland
Christine Lehmann
4Chemical Biology Approaches to Malaria Laboratory, The Francis Crick Institute, London, England, United Kingdom
Fang Yuan
5Department of Pathology, Stanford University School of Medicine, Stanford, United States
Shirin Arastu-Kapur
5Department of Pathology, Stanford University School of Medicine, Stanford, United States
Martin Horn
6Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic
Michael Mares
6Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic
Matthew Bogyo
5Department of Pathology, Stanford University School of Medicine, Stanford, United States
Marcin Drag
3Division of Bioorganic Chemistry, Faculty of Chemistry, Wroclaw University of Technology, Wroclaw, Poland
Edgar Deu
4Chemical Biology Approaches to Malaria Laboratory, The Francis Crick Institute, London, England, United Kingdom
Article usage
Posted August 10, 2018.
Characterization of P. falciparum dipeptidyl aminopeptidase 3 specificity reveals structural factors responsible for differences in amino acid preferences between peptide-based substrates and covalent inhibitors
Laura E. de Vries, Mateo I. Sanchez, Katarzyna Groborz, Laurie Kuppens, Marcin Poreba, Christine Lehmann, Fang Yuan, Shirin Arastu-Kapur, Martin Horn, Michael Mares, Matthew Bogyo, Marcin Drag, Edgar Deu
bioRxiv 246124; doi: https://doi.org/10.1101/246124
Characterization of P. falciparum dipeptidyl aminopeptidase 3 specificity reveals structural factors responsible for differences in amino acid preferences between peptide-based substrates and covalent inhibitors
Laura E. de Vries, Mateo I. Sanchez, Katarzyna Groborz, Laurie Kuppens, Marcin Poreba, Christine Lehmann, Fang Yuan, Shirin Arastu-Kapur, Martin Horn, Michael Mares, Matthew Bogyo, Marcin Drag, Edgar Deu
bioRxiv 246124; doi: https://doi.org/10.1101/246124
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