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Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

View ORCID ProfileJonathan R.I. Coleman, Wouter J. Peyrot, View ORCID ProfileKirstin L. Purves, View ORCID ProfileKatrina A.S. Davis, Christopher Rayner, View ORCID ProfileShing Wan Choi, View ORCID ProfileChristopher Hübel, View ORCID ProfileHéléna A. Gaspar, View ORCID ProfileCarol Kan, View ORCID ProfileSandra Van der Auwera, View ORCID ProfileMark James Adams, View ORCID ProfileDonald M. Lyall, Karmel W. Choi, Jonathan R.I. Coleman, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, View ORCID ProfileErin C. Dunn, View ORCID ProfileEvangelos Vassos, View ORCID ProfileAndrea Danese, Barbara Maughan, View ORCID ProfileHans J. Grabe, View ORCID ProfileCathryn M. Lewis, View ORCID ProfilePaul F. O’Reilly, View ORCID ProfileAndrew M. McIntosh, View ORCID ProfileDaniel J. Smith, View ORCID ProfileNaomi R. Wray, View ORCID ProfileMatthew Hotopf, View ORCID ProfileThalia C. Eley, View ORCID ProfileGerome Breen
doi: https://doi.org/10.1101/247353
Jonathan R.I. Coleman
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UKNIHR Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK
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  • ORCID record for Jonathan R.I. Coleman
Wouter J. Peyrot
Amsterdam UMC, Vrije Universiteit Medical Center, Department of Psychiatry, Amsterdam, The Netherlands
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Kirstin L. Purves
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK
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  • ORCID record for Kirstin L. Purves
Katrina A.S. Davis
NIHR Biomedical Research Centre, South London and Maudsley NHS Trust, London, UKDepartment of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK
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  • ORCID record for Katrina A.S. Davis
Christopher Rayner
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK
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Shing Wan Choi
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK
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  • ORCID record for Shing Wan Choi
Christopher Hübel
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UKNIHR Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK
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  • ORCID record for Christopher Hübel
Héléna A. Gaspar
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UKNIHR Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK
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  • ORCID record for Héléna A. Gaspar
Carol Kan
Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK
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  • ORCID record for Carol Kan
Sandra Van der Auwera
Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany
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  • ORCID record for Sandra Van der Auwera
Mark James Adams
Division of Psychiatry, University of Edinburgh, Edinburgh, UK
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  • ORCID record for Mark James Adams
Donald M. Lyall
Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK
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  • ORCID record for Donald M. Lyall
Karmel W. Choi
Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USAStanley Center for Psychiatric Research, The Broad Institute of Harvard and MIT, Cambridge, MA, USA.Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
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Jonathan R.I. Coleman
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UKNIHR Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK
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Consortium members listed in Supplementary Materials
Erin C. Dunn
Stanley Center for Psychiatric Research, The Broad Institute of Harvard and MIT, Cambridge, MA, USA.Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
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  • ORCID record for Erin C. Dunn
Evangelos Vassos
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UKNIHR Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK
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  • ORCID record for Evangelos Vassos
Andrea Danese
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UKDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UKNational and Specialist CAMHS Trauma and Anxiety Clinic, South London and Maudsley NHS Foundation Trust, London, UK
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Barbara Maughan
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK
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Hans J. Grabe
Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany
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  • ORCID record for Hans J. Grabe
Cathryn M. Lewis
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UKNIHR Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK
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  • ORCID record for Cathryn M. Lewis
Paul F. O’Reilly
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK
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  • ORCID record for Paul F. O’Reilly
Andrew M. McIntosh
Division of Psychiatry, University of Edinburgh, Edinburgh, UK
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  • ORCID record for Andrew M. McIntosh
Daniel J. Smith
Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK
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  • ORCID record for Daniel J. Smith
Naomi R. Wray
Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, AustraliaQueensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia
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Matthew Hotopf
NIHR Biomedical Research Centre, South London and Maudsley NHS Trust, London, UKDepartment of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK
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Thalia C. Eley
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UKNIHR Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK
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  • ORCID record for Thalia C. Eley
  • For correspondence: gerome.breen@kcl.ac.uk thalia.eley@kcl.ac.uk
Gerome Breen
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UKNIHR Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK
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  • ORCID record for Gerome Breen
  • For correspondence: gerome.breen@kcl.ac.uk thalia.eley@kcl.ac.uk
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Posted November 01, 2018.
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Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank
Jonathan R.I. Coleman, Wouter J. Peyrot, Kirstin L. Purves, Katrina A.S. Davis, Christopher Rayner, Shing Wan Choi, Christopher Hübel, Héléna A. Gaspar, Carol Kan, Sandra Van der Auwera, Mark James Adams, Donald M. Lyall, Karmel W. Choi, Jonathan R.I. Coleman, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Erin C. Dunn, Evangelos Vassos, Andrea Danese, Barbara Maughan, Hans J. Grabe, Cathryn M. Lewis, Paul F. O’Reilly, Andrew M. McIntosh, Daniel J. Smith, Naomi R. Wray, Matthew Hotopf, Thalia C. Eley, Gerome Breen
bioRxiv 247353; doi: https://doi.org/10.1101/247353
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Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank
Jonathan R.I. Coleman, Wouter J. Peyrot, Kirstin L. Purves, Katrina A.S. Davis, Christopher Rayner, Shing Wan Choi, Christopher Hübel, Héléna A. Gaspar, Carol Kan, Sandra Van der Auwera, Mark James Adams, Donald M. Lyall, Karmel W. Choi, Jonathan R.I. Coleman, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Erin C. Dunn, Evangelos Vassos, Andrea Danese, Barbara Maughan, Hans J. Grabe, Cathryn M. Lewis, Paul F. O’Reilly, Andrew M. McIntosh, Daniel J. Smith, Naomi R. Wray, Matthew Hotopf, Thalia C. Eley, Gerome Breen
bioRxiv 247353; doi: https://doi.org/10.1101/247353

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