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Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank
View ORCID ProfileJonathan R.I. Coleman, Wouter J. Peyrot, View ORCID ProfileKirstin L. Purves, View ORCID ProfileKatrina A.S. Davis, Christopher Rayner, View ORCID ProfileShing Wan Choi, View ORCID ProfileChristopher Hübel, View ORCID ProfileHéléna A. Gaspar, View ORCID ProfileCarol Kan, View ORCID ProfileSandra Van der Auwera, View ORCID ProfileMark James Adams, View ORCID ProfileDonald M. Lyall, Karmel W. Choi, Jonathan R.I. Coleman, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, View ORCID ProfileErin C. Dunn, View ORCID ProfileEvangelos Vassos, View ORCID ProfileAndrea Danese, Barbara Maughan, View ORCID ProfileHans J. Grabe, View ORCID ProfileCathryn M. Lewis, View ORCID ProfilePaul F. O’Reilly, View ORCID ProfileAndrew M. McIntosh, View ORCID ProfileDaniel J. Smith, View ORCID ProfileNaomi R. Wray, View ORCID ProfileMatthew Hotopf, View ORCID ProfileThalia C. Eley, View ORCID ProfileGerome Breen
doi: https://doi.org/10.1101/247353
Jonathan R.I. Coleman
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UKNIHR Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK
Wouter J. Peyrot
Amsterdam UMC, Vrije Universiteit Medical Center, Department of Psychiatry, Amsterdam, The Netherlands
Kirstin L. Purves
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK
Katrina A.S. Davis
NIHR Biomedical Research Centre, South London and Maudsley NHS Trust, London, UKDepartment of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK
Christopher Rayner
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK
Shing Wan Choi
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK
Christopher Hübel
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UKNIHR Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK
Héléna A. Gaspar
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UKNIHR Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK
Carol Kan
Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK
Sandra Van der Auwera
Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany
Mark James Adams
Division of Psychiatry, University of Edinburgh, Edinburgh, UK
Donald M. Lyall
Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK
Karmel W. Choi
Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USAStanley Center for Psychiatric Research, The Broad Institute of Harvard and MIT, Cambridge, MA, USA.Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Jonathan R.I. Coleman
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UKNIHR Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK
Consortium members listed in Supplementary Materials
Erin C. Dunn
Stanley Center for Psychiatric Research, The Broad Institute of Harvard and MIT, Cambridge, MA, USA.Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
Evangelos Vassos
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UKNIHR Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK
Andrea Danese
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UKDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UKNational and Specialist CAMHS Trauma and Anxiety Clinic, South London and Maudsley NHS Foundation Trust, London, UK
Barbara Maughan
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK
Hans J. Grabe
Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany
Cathryn M. Lewis
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UKNIHR Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK
Paul F. O’Reilly
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK
Andrew M. McIntosh
Division of Psychiatry, University of Edinburgh, Edinburgh, UK
Daniel J. Smith
Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK
Naomi R. Wray
Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, AustraliaQueensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia
Matthew Hotopf
NIHR Biomedical Research Centre, South London and Maudsley NHS Trust, London, UKDepartment of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK
Thalia C. Eley
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UKNIHR Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK
Gerome Breen
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UKNIHR Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK

- Supplementary Figure 1
- Supplementary Figure 2
- Supplementary Figure 3
- Supplementary Figure 4
- Supplementary Figure 5
- Supplementary Figure 6
- Supplementary Figure 7
- Supplementary Figure 8
- Supplementary Figure 9
- Supplementary Figure 10
- Supplementary Material
- Supplementary Tables
- Supplementary Figure 11a
- Supplementary Figure 11b
Posted November 01, 2018.
Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank
Jonathan R.I. Coleman, Wouter J. Peyrot, Kirstin L. Purves, Katrina A.S. Davis, Christopher Rayner, Shing Wan Choi, Christopher Hübel, Héléna A. Gaspar, Carol Kan, Sandra Van der Auwera, Mark James Adams, Donald M. Lyall, Karmel W. Choi, Jonathan R.I. Coleman, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Erin C. Dunn, Evangelos Vassos, Andrea Danese, Barbara Maughan, Hans J. Grabe, Cathryn M. Lewis, Paul F. O’Reilly, Andrew M. McIntosh, Daniel J. Smith, Naomi R. Wray, Matthew Hotopf, Thalia C. Eley, Gerome Breen
bioRxiv 247353; doi: https://doi.org/10.1101/247353
Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank
Jonathan R.I. Coleman, Wouter J. Peyrot, Kirstin L. Purves, Katrina A.S. Davis, Christopher Rayner, Shing Wan Choi, Christopher Hübel, Héléna A. Gaspar, Carol Kan, Sandra Van der Auwera, Mark James Adams, Donald M. Lyall, Karmel W. Choi, Jonathan R.I. Coleman, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Erin C. Dunn, Evangelos Vassos, Andrea Danese, Barbara Maughan, Hans J. Grabe, Cathryn M. Lewis, Paul F. O’Reilly, Andrew M. McIntosh, Daniel J. Smith, Naomi R. Wray, Matthew Hotopf, Thalia C. Eley, Gerome Breen
bioRxiv 247353; doi: https://doi.org/10.1101/247353
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