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Exploring the genetic correlations of antisocial behavior and life history traits

Jorim J. Tielbeek, J.C. Barnes, Arne Popma, Tinca J.C. Polderman, James J. Lee, John R.B. Perry, Danielle Posthuma, Brian B. Boutwell
doi: https://doi.org/10.1101/247411
Jorim J. Tielbeek
1VU University Medical Center Amsterdam
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J.C. Barnes
2University of Cincinnati
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Arne Popma
3VU University Medical Center Amsterdam
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Tinca J.C. Polderman
4VU University Amsterdam
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James J. Lee
5University of Minnesota
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John R.B. Perry
6Cambridge University
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Danielle Posthuma
7VU University Amsterdam
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Brian B. Boutwell
8Saint Louis University
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  • For correspondence: brian.boutwell@slu.edu
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Abstract

Prior evolutionary theory provided reason to suspect that measures of development and reproduction would be correlated with antisocial behaviors in human and non-human species. Behavioral genetics has revealed that most quantitative traits are heritable, suggesting that these phenotypic correlations may share genetic etiologies. We use GWAS data to estimate the genetic correlations between various measures of reproductive development (N= 52,776 – 318,863) and antisocial behavior (N= 31,968). Our genetic correlation analyses demonstrate that alleles associated with higher reproductive output (number of children ever born, rg=0.50, p=.0065) were positively correlated with alleles associated with antisocial behavior, whereas alleles associated with more delayed reproductive onset (age of first birth, rg=-.64, p=.0008) were negatively associated with alleles linked to antisocial behavior. Ultimately, these findings coalesce with evolutionary theories suggesting that increased antisocial behaviors may partly represent a faster life history approach, which may be significantly calibrated by genes.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted August 23, 2018.
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Exploring the genetic correlations of antisocial behavior and life history traits
Jorim J. Tielbeek, J.C. Barnes, Arne Popma, Tinca J.C. Polderman, James J. Lee, John R.B. Perry, Danielle Posthuma, Brian B. Boutwell
bioRxiv 247411; doi: https://doi.org/10.1101/247411
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Exploring the genetic correlations of antisocial behavior and life history traits
Jorim J. Tielbeek, J.C. Barnes, Arne Popma, Tinca J.C. Polderman, James J. Lee, John R.B. Perry, Danielle Posthuma, Brian B. Boutwell
bioRxiv 247411; doi: https://doi.org/10.1101/247411

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