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Small interfering RNAs based on huntingtin trinucleotide repeats are highly toxic to cancer cells

Andrea E. Murmann, Quan Q. Gao, William Putzbach, Monal Patel, Elizabeth T. Bartom, Calvin Law, Bryan Bridgeman, Siquan Chen, Kaylin M. McMahon, C. Shad Thaxton, View ORCID ProfileMarcus E. Peter
doi: https://doi.org/10.1101/247429
Andrea E. Murmann
1Division of Hematology/Oncology
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  • For correspondence: m-peter@northwestern.edu amurmann@northwestern.edu
Quan Q. Gao
1Division of Hematology/Oncology
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William Putzbach
1Division of Hematology/Oncology
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Monal Patel
1Division of Hematology/Oncology
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Elizabeth T. Bartom
2Department of Biochemistry and Molecular Genetics
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Calvin Law
1Division of Hematology/Oncology
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Bryan Bridgeman
1Division of Hematology/Oncology
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Siquan Chen
7Cellular Screening Center, Institute for Genomics & Systems Biology, The University of Chicago, Chicago, IL 60637
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Kaylin M. McMahon
3Department of Urology
5Simpson Querrey Institute (SQI) for BioNanotechnology, 303 East Superior, Chicago, IL 60611, USA
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C. Shad Thaxton
3Department of Urology
4Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Northwestern University, Chicago, IL 60611, USA
5Simpson Querrey Institute (SQI) for BioNanotechnology, 303 East Superior, Chicago, IL 60611, USA
6International Institute for Nanotechnology, Evanston, IL 60208, USA
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Marcus E. Peter
1Division of Hematology/Oncology
2Department of Biochemistry and Molecular Genetics
4Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Northwestern University, Chicago, IL 60611, USA
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  • ORCID record for Marcus E. Peter
  • For correspondence: m-peter@northwestern.edu amurmann@northwestern.edu
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Article Information

doi 
https://doi.org/10.1101/247429
History 
  • January 12, 2018.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Andrea E. Murmann1,*,
  2. Quan Q. Gao1,
  3. William Putzbach1,
  4. Monal Patel1,
  5. Elizabeth T. Bartom2,
  6. Calvin Law1,
  7. Bryan Bridgeman1,
  8. Siquan Chen7,
  9. Kaylin M. McMahon3,5,
  10. C. Shad Thaxton3,4,5,6 and
  11. Marcus E. Peter1,2,4,*
  1. 1Division of Hematology/Oncology
  2. 2Department of Biochemistry and Molecular Genetics
  3. 3Department of Urology
  4. 4Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Northwestern University, Chicago, IL 60611, USA
  5. 5Simpson Querrey Institute (SQI) for BioNanotechnology, 303 East Superior, Chicago, IL 60611, USA
  6. 6International Institute for Nanotechnology, Evanston, IL 60208, USA
  7. 7Cellular Screening Center, Institute for Genomics & Systems Biology, The University of Chicago, Chicago, IL 60637
  1. ↵*Co-corresponding authors: Marcus Peter and Andrea Murmann, email: m-peter{at}northwestern.edu/amurmann{at}northwestern.edu
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Posted January 12, 2018.
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Small interfering RNAs based on huntingtin trinucleotide repeats are highly toxic to cancer cells
Andrea E. Murmann, Quan Q. Gao, William Putzbach, Monal Patel, Elizabeth T. Bartom, Calvin Law, Bryan Bridgeman, Siquan Chen, Kaylin M. McMahon, C. Shad Thaxton, Marcus E. Peter
bioRxiv 247429; doi: https://doi.org/10.1101/247429
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Small interfering RNAs based on huntingtin trinucleotide repeats are highly toxic to cancer cells
Andrea E. Murmann, Quan Q. Gao, William Putzbach, Monal Patel, Elizabeth T. Bartom, Calvin Law, Bryan Bridgeman, Siquan Chen, Kaylin M. McMahon, C. Shad Thaxton, Marcus E. Peter
bioRxiv 247429; doi: https://doi.org/10.1101/247429

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