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Precise temporal regulation of alternative splicing during neural development

Sebastien M. Weyn-Vanhentenryck, Huijuan Feng, Dmytro Ustianenko, Rachel Duffié, Qinghong Yan, Martin Jacko, Jose C. Martinez, Marianne Goodwin, Xuegong Zhang, Ulrich Hengst, Stavros Lomvardas, Maurice S. Swanson, Chaolin Zhang
doi: https://doi.org/10.1101/247601
Sebastien M. Weyn-Vanhentenryck
1 Department of Systems Biology, Department of Biochemistry and Molecular Biophysics, Center for Motor Neuron Biology and Disease, Columbia University, New York NY 10032, USA
7Equal contribution
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Huijuan Feng
1 Department of Systems Biology, Department of Biochemistry and Molecular Biophysics, Center for Motor Neuron Biology and Disease, Columbia University, New York NY 10032, USA
2 MOE Key Laboratory of Bioinformatics and Bioinformatics Division, TNLIST/Department of Automation, Tsinghua University, Beijing 100084, China
7Equal contribution
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Dmytro Ustianenko
1 Department of Systems Biology, Department of Biochemistry and Molecular Biophysics, Center for Motor Neuron Biology and Disease, Columbia University, New York NY 10032, USA
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Rachel Duffié
3Department of Biochemistry and Molecular Biophysics, Mortimer B. Zuckerman Mind Brain and Behavior Institute, Columbia University, New York, NY 10027, USA
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Qinghong Yan
1 Department of Systems Biology, Department of Biochemistry and Molecular Biophysics, Center for Motor Neuron Biology and Disease, Columbia University, New York NY 10032, USA
4 Present address: Department of Comparative Biology and Safety Sciences, Amgen Inc., Cambridge, MA 02141, USA
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Martin Jacko
1 Department of Systems Biology, Department of Biochemistry and Molecular Biophysics, Center for Motor Neuron Biology and Disease, Columbia University, New York NY 10032, USA
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Jose C. Martinez
5 The Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Department of Pathology and Cell Biology, Columbia University, New York NY 10032, USA
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Marianne Goodwin
6 Department of Molecular Genetics and Microbiology, Center for NeuroGenetics and the Genetics Institute, University of Florida, College of Medicine, Gainesville, FL 32610, USA
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Xuegong Zhang
2 MOE Key Laboratory of Bioinformatics and Bioinformatics Division, TNLIST/Department of Automation, Tsinghua University, Beijing 100084, China
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Ulrich Hengst
5 The Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Department of Pathology and Cell Biology, Columbia University, New York NY 10032, USA
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Stavros Lomvardas
4 Present address: Department of Comparative Biology and Safety Sciences, Amgen Inc., Cambridge, MA 02141, USA
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Maurice S. Swanson
6 Department of Molecular Genetics and Microbiology, Center for NeuroGenetics and the Genetics Institute, University of Florida, College of Medicine, Gainesville, FL 32610, USA
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Chaolin Zhang
1 Department of Systems Biology, Department of Biochemistry and Molecular Biophysics, Center for Motor Neuron Biology and Disease, Columbia University, New York NY 10032, USA
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  • For correspondence: cz2294@columbia.edu
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Article Information

doi 
https://doi.org/10.1101/247601
History 
  • January 14, 2018.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Sebastien M. Weyn-Vanhentenryck1,7,
  2. Huijuan Feng1,2,7,
  3. Dmytro Ustianenko1,
  4. Rachel Duffié3,
  5. Qinghong Yan1,4,
  6. Martin Jacko1,
  7. Jose C. Martinez5,
  8. Marianne Goodwin6,
  9. Xuegong Zhang2,
  10. Ulrich Hengst5,
  11. Stavros Lomvardas4,
  12. Maurice S. Swanson6 and
  13. Chaolin Zhang1,*
  1. 1 Department of Systems Biology, Department of Biochemistry and Molecular Biophysics, Center for Motor Neuron Biology and Disease, Columbia University, New York NY 10032, USA
  2. 2 MOE Key Laboratory of Bioinformatics and Bioinformatics Division, TNLIST/Department of Automation, Tsinghua University, Beijing 100084, China
  3. 3Department of Biochemistry and Molecular Biophysics, Mortimer B. Zuckerman Mind Brain and Behavior Institute, Columbia University, New York, NY 10027, USA
  4. 4 Present address: Department of Comparative Biology and Safety Sciences, Amgen Inc., Cambridge, MA 02141, USA
  5. 5 The Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Department of Pathology and Cell Biology, Columbia University, New York NY 10032, USA
  6. 6 Department of Molecular Genetics and Microbiology, Center for NeuroGenetics and the Genetics Institute, University of Florida, College of Medicine, Gainesville, FL 32610, USA
  7. 7Equal contribution
  1. ↵*To whom correspondence should be addressed: cz2294{at}columbia.edu
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Posted January 14, 2018.
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Precise temporal regulation of alternative splicing during neural development
Sebastien M. Weyn-Vanhentenryck, Huijuan Feng, Dmytro Ustianenko, Rachel Duffié, Qinghong Yan, Martin Jacko, Jose C. Martinez, Marianne Goodwin, Xuegong Zhang, Ulrich Hengst, Stavros Lomvardas, Maurice S. Swanson, Chaolin Zhang
bioRxiv 247601; doi: https://doi.org/10.1101/247601
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Precise temporal regulation of alternative splicing during neural development
Sebastien M. Weyn-Vanhentenryck, Huijuan Feng, Dmytro Ustianenko, Rachel Duffié, Qinghong Yan, Martin Jacko, Jose C. Martinez, Marianne Goodwin, Xuegong Zhang, Ulrich Hengst, Stavros Lomvardas, Maurice S. Swanson, Chaolin Zhang
bioRxiv 247601; doi: https://doi.org/10.1101/247601

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