Analysis of human immunoglobulin VDJ and DJ rearrangements shows N region synthesis by concatenation of cytosine-rich strands preferentially originating from trimmed germline gene segments

Tina Funck; Mike Bogetofte Barnkob; Nanna Holm; Line Ohm-Laursen; Camilla Slot Mehlum; Sören Möller; Torben Barington

doi:10.1101/248021

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Analysis of human immunoglobulin VDJ and DJ rearrangements shows N region synthesis by concatenation of cytosine-rich strands preferentially originating from trimmed germline gene segments

View ORCID ProfileTina Funck, View ORCID ProfileMike Bogetofte Barnkob, Nanna Holm, Line Ohm-Laursen, View ORCID ProfileCamilla Slot Mehlum, View ORCID ProfileSören Möller, View ORCID ProfileTorben Barington

doi: https://doi.org/10.1101/248021

Tina Funck

†Department of Clinical Immunology, Odense University Hospital, Odense, Denmark.

*Department of Clinical Biochemistry, Zealand University Hospital, Roskilde, Denmark.

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ORCID record for Tina Funck

Mike Bogetofte Barnkob

†Department of Clinical Immunology, Odense University Hospital, Odense, Denmark.

‡Currently at MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxfordshire, UK.

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ORCID record for Mike Bogetofte Barnkob

Nanna Holm

†Department of Clinical Immunology, Odense University Hospital, Odense, Denmark.

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Line Ohm-Laursen

§Randall Division of Cell & Molecular Biophysics, School of Basic and Medical Biosciences, King’s College London, London, UK.

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Camilla Slot Mehlum

¶Department of ORL – Head & Neck Surgery, Odense University Hospital, Odense, Denmark.

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Sören Möller

#OPEN, Odense Patient data Explorative Network, Odense University Hospital, Odense, Denmark.

$Clinical Department, University of Southern Denmark, Odense, Denmark.

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Torben Barington

†Department of Clinical Immunology, Odense University Hospital, Odense, Denmark.

#OPEN, Odense Patient data Explorative Network, Odense University Hospital, Odense, Denmark.

$Clinical Department, University of Southern Denmark, Odense, Denmark.

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ORCID record for Torben Barington

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Posted January 23, 2018.

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Analysis of human immunoglobulin VDJ and DJ rearrangements shows N region synthesis by concatenation of cytosine-rich strands preferentially originating from trimmed germline gene segments

Tina Funck, Mike Bogetofte Barnkob, Nanna Holm, Line Ohm-Laursen, Camilla Slot Mehlum, Sören Möller, Torben Barington

bioRxiv 248021; doi: https://doi.org/10.1101/248021

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Analysis of human immunoglobulin VDJ and DJ rearrangements shows N region synthesis by concatenation of cytosine-rich strands preferentially originating from trimmed germline gene segments

Tina Funck, Mike Bogetofte Barnkob, Nanna Holm, Line Ohm-Laursen, Camilla Slot Mehlum, Sören Möller, Torben Barington

bioRxiv 248021; doi: https://doi.org/10.1101/248021

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