Genome-Encoded Cytoplasmic Double-Stranded RNAs, Found in C9ORF72 ALS-FTD Brain, Provoke Propagated Neuronal Death

Steven Rodriguez; Benjamin R. Schrank; Asli Sahin; Hawra Al-Lawati; Isabel Costantino; Eric Benz; Darian Fard; Alefiya D. Albers; Luxiang Cao; Alexis C. Gomez; Elena Ratti; Merit Cudkowicz; Matthew P. Frosch; Michael Talkowski; Peter K. Sorger; Bradley T. Hyman; Mark W. Albers

doi:10.1101/248328

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Genome-Encoded Cytoplasmic Double-Stranded RNAs, Found in C9ORF72 ALS-FTD Brain, Provoke Propagated Neuronal Death

Steven Rodriguez, Benjamin R. Schrank, Asli Sahin, Hawra Al-Lawati, Isabel Costantino, Eric Benz, Darian Fard, View ORCID ProfileAlefiya D. Albers, Luxiang Cao, Alexis C. Gomez, Elena Ratti, Merit Cudkowicz, Matthew P. Frosch, Michael Talkowski, Peter K. Sorger, Bradley T. Hyman, Mark W. Albers

doi: https://doi.org/10.1101/248328

Steven Rodriguez

1Department of Neurology, Massachusetts General Hospital, Boston, MA

55Harvard Program in Therapeutic Science, Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA 02115

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Benjamin R. Schrank

1Department of Neurology, Massachusetts General Hospital, Boston, MA

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Asli Sahin

1Department of Neurology, Massachusetts General Hospital, Boston, MA

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Hawra Al-Lawati

1Department of Neurology, Massachusetts General Hospital, Boston, MA

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Isabel Costantino

1Department of Neurology, Massachusetts General Hospital, Boston, MA

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Eric Benz

1Department of Neurology, Massachusetts General Hospital, Boston, MA

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Darian Fard

1Department of Neurology, Massachusetts General Hospital, Boston, MA

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Alefiya D. Albers

1Department of Neurology, Massachusetts General Hospital, Boston, MA

2Department of Psychology, Endicott College, Beverly MA

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ORCID record for Alefiya D. Albers

Luxiang Cao

1Department of Neurology, Massachusetts General Hospital, Boston, MA

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Alexis C. Gomez

1Department of Neurology, Massachusetts General Hospital, Boston, MA

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Elena Ratti

1Department of Neurology, Massachusetts General Hospital, Boston, MA

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Merit Cudkowicz

1Department of Neurology, Massachusetts General Hospital, Boston, MA

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Matthew P. Frosch

3Department of Pathology, Massachusetts General Hospital, Boston, MA

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Michael Talkowski

4Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA

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Peter K. Sorger

55Harvard Program in Therapeutic Science, Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA 02115

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Bradley T. Hyman

55Harvard Program in Therapeutic Science, Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA 02115

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Mark W. Albers

1Department of Neurology, Massachusetts General Hospital, Boston, MA

55Harvard Program in Therapeutic Science, Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA 02115

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Posted January 19, 2018.

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Genome-Encoded Cytoplasmic Double-Stranded RNAs, Found in C9ORF72 ALS-FTD Brain, Provoke Propagated Neuronal Death

Steven Rodriguez, Benjamin R. Schrank, Asli Sahin, Hawra Al-Lawati, Isabel Costantino, Eric Benz, Darian Fard, Alefiya D. Albers, Luxiang Cao, Alexis C. Gomez, Elena Ratti, Merit Cudkowicz, Matthew P. Frosch, Michael Talkowski, Peter K. Sorger, Bradley T. Hyman, Mark W. Albers

bioRxiv 248328; doi: https://doi.org/10.1101/248328

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