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Loss of mitochondrial SIRT4 shortens lifespan and leads to a decline in physical activity

Sweta Parik, Sandipan Tewary, Champakali Ayyub, Ullas Kolthur-Seetharam
doi: https://doi.org/10.1101/248831
Sweta Parik
Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, Maharashtra, India
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Sandipan Tewary
Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, Maharashtra, India
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Champakali Ayyub
Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, Maharashtra, India
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Ullas Kolthur-Seetharam
Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, Maharashtra, India
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  • For correspondence: ullas@tifr.res.in
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Summary

Mitochondrial mechanisms and pathways have recently emerged as critical determinants of organismal aging. While nuclear sirtuins have been shown to regulate aging, whether mitochondrial sirtuins do so is still unclear. Here, we report that mitochondrial dSirt4 mediates organismal survival. We establish that absence of dSirt4 leads to reduced lifespan independent of dietary inputs. Further by assaying locomotion, a key correlate of aging, we demonstrate that dSirt4 null flies are severely physically impaired with a significant reduction in locomotion. In summary, we report for the first time that mitochondrial dSirt4 is a key determinant of longevity and its loss leads to early aging.

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Posted January 16, 2018.
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Loss of mitochondrial SIRT4 shortens lifespan and leads to a decline in physical activity
Sweta Parik, Sandipan Tewary, Champakali Ayyub, Ullas Kolthur-Seetharam
bioRxiv 248831; doi: https://doi.org/10.1101/248831
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Loss of mitochondrial SIRT4 shortens lifespan and leads to a decline in physical activity
Sweta Parik, Sandipan Tewary, Champakali Ayyub, Ullas Kolthur-Seetharam
bioRxiv 248831; doi: https://doi.org/10.1101/248831

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