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From preliminary to definitive plans: two classes of neurons in frontal eye field

Joshua I. Glaser, Daniel K. Wood, Patrick N. Lawlor, Mark A. Segraves, Konrad P. Kording
doi: https://doi.org/10.1101/251835
Joshua I. Glaser
1Interdepartmental Neuroscience Program, Northwestern University, Chicago, IL, USA
2Department of Physical Medicine and Rehabilitation, Northwestern University and Shirley Ryan Ability Lab, Chicago, IL, USA
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Daniel K. Wood
3Department of Neurobiology, Northwestern University, Evanston, IL, USA
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Patrick N. Lawlor
1Interdepartmental Neuroscience Program, Northwestern University, Chicago, IL, USA
2Department of Physical Medicine and Rehabilitation, Northwestern University and Shirley Ryan Ability Lab, Chicago, IL, USA
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Mark A. Segraves
3Department of Neurobiology, Northwestern University, Evanston, IL, USA
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Konrad P. Kording
2Department of Physical Medicine and Rehabilitation, Northwestern University and Shirley Ryan Ability Lab, Chicago, IL, USA
4Department of Neuroscience, University of Pennsylvania, Philadelphia, IL, USA
5Department of Biomedical Engineering, University of Pennsylvania, Philadelphia, IL, USA
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Abstract

Prior to selecting an action, we often consider other possibilities. How does the brain represent these preliminary plans prior to action selection? Here, we investigated this question in the oculomotor system during self-guided search of natural scenes. We found two classes of neurons in the frontal eye field (FEF): 1) “late selection neurons” that represented the selected action plan not long before the upcoming saccade, and 2) “early selection neurons” that became predictive of the upcoming saccade much earlier, often before the previous saccade had even ended. Crucially, these early selection neurons did not only predict the upcoming saccade direction; they also reflected the probabilities of possible upcoming saccades, even when they did not end up being selected. Our results demonstrate that during naturalistic eye movements, separate populations of neurons code for preliminary and definitive plans.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted February 07, 2018.
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From preliminary to definitive plans: two classes of neurons in frontal eye field
Joshua I. Glaser, Daniel K. Wood, Patrick N. Lawlor, Mark A. Segraves, Konrad P. Kording
bioRxiv 251835; doi: https://doi.org/10.1101/251835
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From preliminary to definitive plans: two classes of neurons in frontal eye field
Joshua I. Glaser, Daniel K. Wood, Patrick N. Lawlor, Mark A. Segraves, Konrad P. Kording
bioRxiv 251835; doi: https://doi.org/10.1101/251835

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