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Task-Evoked Functional Connectivity Does Not Explain Functional Connectivity Differences Between Rest and Task Conditions

Lauren K. Lynch, Kun-Han Lu, Haiguang Wen, Yizhen Zhang, Andrew J. Saykin, Zhongming Liu
doi: https://doi.org/10.1101/252759
Lauren K. Lynch
1Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana
2Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, Indiana
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Kun-Han Lu
2Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, Indiana
3School of Electrical and Computer Engineering, Purdue University, West Lafayette, Indiana
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Haiguang Wen
2Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, Indiana
3School of Electrical and Computer Engineering, Purdue University, West Lafayette, Indiana
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Yizhen Zhang
2Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, Indiana
3School of Electrical and Computer Engineering, Purdue University, West Lafayette, Indiana
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Andrew J. Saykin
4Center for Neuroimaging, Department of Radiology and Imaging Sciences and Indiana
5Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, Indiana
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Zhongming Liu
1Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana
2Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, Indiana
3School of Electrical and Computer Engineering, Purdue University, West Lafayette, Indiana
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  • For correspondence: zmliu@purdue.edu
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Abstract

During complex tasks, patterns of functional connectivity (FC) differ from those in the resting state. What accounts for such differences remains unclear. Brain activity during a task reflects an unknown mixture of spontaneous activity and task-evoked responses. The difference in FC between a task state and resting state may reflect not only task-evoked connectivity, but also changes in spontaneously emerging networks. Here, we characterized the difference in apparent functional connectivity between the resting state and when human subjects were watching a naturalistic movie. Such differences were marginally (3-15%) explained by the task-evoked networks directly involved in processing the movie content, but mostly attributable to changes in spontaneous networks driven by ongoing activity during the task. The execution of the task reduced the correlations in ongoing activity among different cortical networks, especially between the visual and non-visual sensory cortices. Our results suggest that the interaction between spontaneous and task-evoked activities is not mutually independent or linearly additive, and that engaging in a task may suppress ongoing activity.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted January 24, 2018.
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Task-Evoked Functional Connectivity Does Not Explain Functional Connectivity Differences Between Rest and Task Conditions
Lauren K. Lynch, Kun-Han Lu, Haiguang Wen, Yizhen Zhang, Andrew J. Saykin, Zhongming Liu
bioRxiv 252759; doi: https://doi.org/10.1101/252759
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Task-Evoked Functional Connectivity Does Not Explain Functional Connectivity Differences Between Rest and Task Conditions
Lauren K. Lynch, Kun-Han Lu, Haiguang Wen, Yizhen Zhang, Andrew J. Saykin, Zhongming Liu
bioRxiv 252759; doi: https://doi.org/10.1101/252759

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