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The Folding Pathway of an Ig Domain is Conserved On and Off the Ribosome

Pengfei Tian, Annette Steward, Renuka Kudva, Ting Su, Patrick J. Shilling, Adrian A. Nickson, Jeffrey J. Hollins, Roland Beckmann, Gunnar Von Heijne, Robert B. Best, Jane Clarke
doi: https://doi.org/10.1101/253013
Pengfei Tian
1Laboratory of Chemical Physics, NIDDK, National Institutes of Health, 5 Memorial Drive, Bethesda, MD 20892-0520, USA.
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Annette Steward
2Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
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Renuka Kudva
3Department of Biochemistry and Biophysics, Stockholm University, SE-10691 Stockholm, Sweden.
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Ting Su
5Gene Center, Department of Biochemistry and Center for Integrated Protein Science Munich, CiPS-M, Feodor-Lynen-Strasse 25, Ludwig Maximilian University of Munich, 81377 Munich, Germany.
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Patrick J. Shilling
3Department of Biochemistry and Biophysics, Stockholm University, SE-10691 Stockholm, Sweden.
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Adrian A. Nickson
2Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
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Jeffrey J. Hollins
2Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
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Roland Beckmann
5Gene Center, Department of Biochemistry and Center for Integrated Protein Science Munich, CiPS-M, Feodor-Lynen-Strasse 25, Ludwig Maximilian University of Munich, 81377 Munich, Germany.
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Gunnar Von Heijne
3Department of Biochemistry and Biophysics, Stockholm University, SE-10691 Stockholm, Sweden.
4Science for Life Laboratory Stockholm University, Box 1031, SE-171 21 Solna, Sweden.
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Robert B. Best
1Laboratory of Chemical Physics, NIDDK, National Institutes of Health, 5 Memorial Drive, Bethesda, MD 20892-0520, USA.
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Jane Clarke
2Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
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Article Information

doi 
https://doi.org/10.1101/253013
History 
  • January 24, 2018.

Article Versions

  • You are currently viewing Version 1 of this article (January 24, 2018 - 13:20).
  • View Version 2, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Pengfei Tian1,‡,
  2. Annette Steward2,‡,
  3. Renuka Kudva3,‡,
  4. Ting Su5,‡,
  5. Patrick J. Shilling3,
  6. Adrian A. Nickson2,
  7. Jeffrey J. Hollins2,
  8. Roland Beckmann5,
  9. Gunnar Von Heijne3,4,#,
  10. Robert B. Best1,# and
  11. Jane Clarke2,#
  1. 1Laboratory of Chemical Physics, NIDDK, National Institutes of Health, 5 Memorial Drive, Bethesda, MD 20892-0520, USA.
  2. 2Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
  3. 3Department of Biochemistry and Biophysics, Stockholm University, SE-10691 Stockholm, Sweden.
  4. 4Science for Life Laboratory Stockholm University, Box 1031, SE-171 21 Solna, Sweden.
  5. 5Gene Center, Department of Biochemistry and Center for Integrated Protein Science Munich, CiPS-M, Feodor-Lynen-Strasse 25, Ludwig Maximilian University of Munich, 81377 Munich, Germany.
  1. ↵# Corresponding authors
  1. ↵‡ P.T., A.S., R.K. and T.S. contributed equally to this work.

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Posted January 24, 2018.
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The Folding Pathway of an Ig Domain is Conserved On and Off the Ribosome
Pengfei Tian, Annette Steward, Renuka Kudva, Ting Su, Patrick J. Shilling, Adrian A. Nickson, Jeffrey J. Hollins, Roland Beckmann, Gunnar Von Heijne, Robert B. Best, Jane Clarke
bioRxiv 253013; doi: https://doi.org/10.1101/253013
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The Folding Pathway of an Ig Domain is Conserved On and Off the Ribosome
Pengfei Tian, Annette Steward, Renuka Kudva, Ting Su, Patrick J. Shilling, Adrian A. Nickson, Jeffrey J. Hollins, Roland Beckmann, Gunnar Von Heijne, Robert B. Best, Jane Clarke
bioRxiv 253013; doi: https://doi.org/10.1101/253013

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