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Binding during sequence learning does not alter cortical representations of individual actions

View ORCID ProfilePatrick Beukema, View ORCID ProfileJörn Diedrichsen, View ORCID ProfileTimothy Verstynen
doi: https://doi.org/10.1101/255794
Patrick Beukema
1Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, 15260
2Center for the Neural Basis of Cognition, University of Pittsburgh & Carnegie Mellon University, Pittsburgh, Pennsylvania, 15213
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Jörn Diedrichsen
3Brain and Mind Institute, Departments of Statistics & Computer Science, University of Western Ontario
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Timothy Verstynen
4Department of Psychology, Carnegie Mellon University, Pittsburgh, Pennsylvania, 15213
2Center for the Neural Basis of Cognition, University of Pittsburgh & Carnegie Mellon University, Pittsburgh, Pennsylvania, 15213
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ABSTRACT

As a movement sequence is learned, serially ordered actions get bound together into sets in order to reduce computational complexity during planning and execution. Here we examined how the binding of serial actions alters the cortical representations of individual movements. Across five weeks of practice, healthy human subjects learned either a complex 32-item sequence of finger movements (Trained group, N=9) or randomly ordered actions (Control group, N=9). After five weeks of training, responses during sequence production in the Trained group were correlated, consistent with being bound together under a common command. These behavioral changes, however, did not coincide with plasticity in the multivariate representations of individual finger movements, assessed using fMRI, at any level of the cortical motor hierarchy. This suggests that the representations of individual actions remain stable, even as the execution of those same actions become bound together in the context of producing a well learned sequence.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted January 30, 2018.
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Binding during sequence learning does not alter cortical representations of individual actions
Patrick Beukema, Jörn Diedrichsen, Timothy Verstynen
bioRxiv 255794; doi: https://doi.org/10.1101/255794
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Binding during sequence learning does not alter cortical representations of individual actions
Patrick Beukema, Jörn Diedrichsen, Timothy Verstynen
bioRxiv 255794; doi: https://doi.org/10.1101/255794

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