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The behavioral and neurobiological effects of reduced Brd1 expression in mice are sex-biased and implicate gender dependent dysregulation of nuclear receptor mediated signaling in mental disorders
Anto P. Rajkumar, View ORCID ProfilePer Qvist, Sanne H. Larsen, Ross Lazarus, Jonatan Pallesen, Nicoletta Nava, Gudrun Winther, Nico Liebenberg, Veerle Paternoster, Tue Fryland, Johan Palmfeldt, Kim Fejgin, Arne Mørk, Mette Nyegaard, Bente Pakkenberg, Michael Didriksen, Jens R. Nyengaard, Gregers Wegener, Ole Mors, Jane H. Christensen, Anders D. Børglum
doi: https://doi.org/10.1101/257170
Anto P. Rajkumar
1iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark;
2Department of Biomedicine, Aarhus University, Aarhus, Denmark;
3Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark;
4Mental Health of Older Adults and Dementia Clinical Academic Group, South London and Maudsley NHS foundation Trust, London, UK;
5Department of old age psychiatry, Institute of Psychiatry, Psychology, & Neuroscience, King’s College London, London, UK;
M.D., M.R.C.Psych., Ph.D., Ph.D.Per Qvist
1iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark;
2Department of Biomedicine, Aarhus University, Aarhus, Denmark;
3Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark;
6Synaptic transmission, H. Lundbeck A/S, Copenhagen, Denmark;
Ph.D.Sanne H. Larsen
1iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark;
2Department of Biomedicine, Aarhus University, Aarhus, Denmark;
3Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark;
M.Sc.Ross Lazarus
7Computational Biology, Baker IDI heart and diabetes institute, Melbourne, Australia;
M.D., Ph.D.Jonatan Pallesen
1iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark;
2Department of Biomedicine, Aarhus University, Aarhus, Denmark;
3Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark;
Ph.D.Nicoletta Nava
9Translational Neuropsychiatry Unit, Aarhus University Hospital, Aarhus, Denmark;
11Core Centre for Molecular Morphology, Section for Stereology and Microscopy, Department of Clinical Medicine, Centre for Stochastic Geometry and Advanced Bioimaging, Department of Clinical Medicine, Aarhus University, Denmark;
Ph.D.Gudrun Winther
9Translational Neuropsychiatry Unit, Aarhus University Hospital, Aarhus, Denmark;
M.Sc.Nico Liebenberg
9Translational Neuropsychiatry Unit, Aarhus University Hospital, Aarhus, Denmark;
Ph.D.Veerle Paternoster
1iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark;
2Department of Biomedicine, Aarhus University, Aarhus, Denmark;
3Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark;
Ph.D.Tue Fryland
1iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark;
2Department of Biomedicine, Aarhus University, Aarhus, Denmark;
3Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark;
Ph.D.Johan Palmfeldt
8Research Unit for Molecular Medicine, Aarhus University Hospital, Denmark;
Ph.D.Kim Fejgin
6Synaptic transmission, H. Lundbeck A/S, Copenhagen, Denmark;
Ph.D.Arne Mørk
6Synaptic transmission, H. Lundbeck A/S, Copenhagen, Denmark;
Ph.D.Mette Nyegaard
1iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark;
2Department of Biomedicine, Aarhus University, Aarhus, Denmark;
3Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark;
Ph.D.Bente Pakkenberg
10Research Laboratory for Stereology and Neuroscience, Bispebjerg University Hospital, Copenhagen, Denmark;
M.D., Ph.D.Michael Didriksen
6Synaptic transmission, H. Lundbeck A/S, Copenhagen, Denmark;
Ph.D.Jens R. Nyengaard
11Core Centre for Molecular Morphology, Section for Stereology and Microscopy, Department of Clinical Medicine, Centre for Stochastic Geometry and Advanced Bioimaging, Department of Clinical Medicine, Aarhus University, Denmark;
M.D., D.M.Sc.Gregers Wegener
9Translational Neuropsychiatry Unit, Aarhus University Hospital, Aarhus, Denmark;
M.D., D.M.Sc.Ole Mors
2Department of Biomedicine, Aarhus University, Aarhus, Denmark;
3Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark;
12Psychosis Research Unit, Aarhus University Hospital, Aarhus, Denmark.
M.D., Ph.D.Jane H. Christensen
1iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark;
2Department of Biomedicine, Aarhus University, Aarhus, Denmark;
3Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark;
Ph.D.Anders D. Børglum
1iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark;
2Department of Biomedicine, Aarhus University, Aarhus, Denmark;
3Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark;
M.D., Ph.D.
Posted January 31, 2018.
The behavioral and neurobiological effects of reduced Brd1 expression in mice are sex-biased and implicate gender dependent dysregulation of nuclear receptor mediated signaling in mental disorders
Anto P. Rajkumar, Per Qvist, Sanne H. Larsen, Ross Lazarus, Jonatan Pallesen, Nicoletta Nava, Gudrun Winther, Nico Liebenberg, Veerle Paternoster, Tue Fryland, Johan Palmfeldt, Kim Fejgin, Arne Mørk, Mette Nyegaard, Bente Pakkenberg, Michael Didriksen, Jens R. Nyengaard, Gregers Wegener, Ole Mors, Jane H. Christensen, Anders D. Børglum
bioRxiv 257170; doi: https://doi.org/10.1101/257170
The behavioral and neurobiological effects of reduced Brd1 expression in mice are sex-biased and implicate gender dependent dysregulation of nuclear receptor mediated signaling in mental disorders
Anto P. Rajkumar, Per Qvist, Sanne H. Larsen, Ross Lazarus, Jonatan Pallesen, Nicoletta Nava, Gudrun Winther, Nico Liebenberg, Veerle Paternoster, Tue Fryland, Johan Palmfeldt, Kim Fejgin, Arne Mørk, Mette Nyegaard, Bente Pakkenberg, Michael Didriksen, Jens R. Nyengaard, Gregers Wegener, Ole Mors, Jane H. Christensen, Anders D. Børglum
bioRxiv 257170; doi: https://doi.org/10.1101/257170
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