New Results
Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders
Raymond K. Walters, View ORCID ProfileMark J. Adams, View ORCID ProfileAmy E. Adkins, View ORCID ProfileFazil Aliev, View ORCID ProfileSilviu-Alin Bacanu, View ORCID ProfileAnthony Batzler, View ORCID ProfileSarah Bertelsen, View ORCID ProfileJoanna Biernacka, View ORCID ProfileTim B. Bigdeli, View ORCID ProfileLi-Shiun Chen, View ORCID ProfileToni-Kim Clarke, Yi-Ling Chou, View ORCID ProfileFranziska Degenhardt, View ORCID ProfileAnna R. Docherty, Pierre Fontanillas, Jerome Foo, View ORCID ProfileLouis Fox, View ORCID ProfileJosef Frank, View ORCID ProfileIna Giegling, Scott Gordon, View ORCID ProfileLaura M. Hack, View ORCID ProfileAnnette M. Hartmann, View ORCID ProfileSarah M. Hartz, View ORCID ProfileStefanie Heilmann-Heimbach, View ORCID ProfileStefan Herms, View ORCID ProfileColin Hodgkinson, View ORCID ProfilePer Hoffmann, View ORCID ProfileJouke-Jan Hottenga, View ORCID ProfileMartin A. Kennedy, Mervi Alanne-Kinnunen, View ORCID ProfileBettina Konte, View ORCID ProfileJari Lahti, View ORCID ProfileMarius Lahti-Pulkkinen, View ORCID ProfileLannie Ligthart, View ORCID ProfileAnu-Maria Loukola, View ORCID ProfileBrion S. Maher, View ORCID ProfileHamdi Mbarek, View ORCID ProfileAndrew M. McIntosh, View ORCID ProfileMatthew B. McQueen, View ORCID ProfileYuri Milaneschi, View ORCID ProfileTeemu Palviainen, View ORCID ProfileJohn F. Pearson, View ORCID ProfileRoseann E. Peterson, View ORCID ProfileRenato Polimanti, View ORCID ProfileSamuli Ripatti, View ORCID ProfileEuijung Ryu, View ORCID ProfileNancy L. Saccone, View ORCID ProfileJessica E. Salvatore, Sandra Sanchez-Roige, Melanie Schwandt, View ORCID ProfileRichard Sherva, View ORCID ProfileFabian Streit, View ORCID ProfileJana Strohmaier, View ORCID ProfileNathaniel Thomas, View ORCID ProfileJen-Chyong Wang, View ORCID ProfileBradley T. Webb, View ORCID ProfileRobbee Wedow, View ORCID ProfileLeah Wetherill, View ORCID ProfileAmanda G. Wills, 23andMe Research Team, View ORCID ProfileJason D. Boardman, Danfeng Chen, View ORCID ProfileDoo-Sup Choi, View ORCID ProfileWilliam E. Copeland, View ORCID ProfileRobert C. Culverhouse, Norbert Dahmen, View ORCID ProfileLouisa Degenhardt, View ORCID ProfileBenjamin W. Domingue, Sarah L. Elson, View ORCID ProfileMark Frye, Wolfgang Gäbel, View ORCID ProfileMarcus Ising, Emma C. Johnson, Margaret Keyes, View ORCID ProfileFalk Kiefer, View ORCID ProfileJohn Kramer, View ORCID ProfileSamuel Kuperman, View ORCID ProfileSusanne Lucae, View ORCID ProfileMichael T. Lynskey, View ORCID ProfileWolfgang Maier, View ORCID ProfileKarl Mann, Satu Männistö, View ORCID ProfileJeanette Nance McClintick, View ORCID ProfileJacquelyn L. Meyers, View ORCID ProfileBertram Müller-Myhsok, View ORCID ProfileJohn I. Nurnberger, View ORCID ProfileAarno Palotie, Ulrich Preuss, View ORCID ProfileKatri Räikkönen, View ORCID ProfileMaureen D. Reynolds, View ORCID ProfileMonika Ridinger, View ORCID ProfileNorbert Scherbaum, Marc Shuckit, View ORCID ProfileMichael Soyka, View ORCID ProfileJens Treutlein, View ORCID ProfileStephanie Witt, View ORCID ProfileNorbert Wodarz, View ORCID ProfilePeter Zill, View ORCID ProfileDaniel E. Adkins, View ORCID ProfileJoseph M. Boden, View ORCID ProfileDorret Boomsma, View ORCID ProfileLaura J Bierut, View ORCID ProfileSandra A. Brown, View ORCID ProfileKathleen K. Bucholz, View ORCID ProfileSven Cichon, View ORCID ProfileE. Jane Costello, Harriet de Wit, Nancy Diazgranados, View ORCID ProfileDanielle M. Dick, View ORCID ProfileJohan G. Eriksson, View ORCID ProfileLindsay A. Farrer, View ORCID ProfileTatiana M. Foroud, View ORCID ProfileNathan A. Gillespie, View ORCID ProfileAlison A. Goate, View ORCID ProfileDavid Goldman, View ORCID ProfileRichard A. Grucza, View ORCID ProfileDana B. Hancock, View ORCID ProfileKathleen Mullan Harris, View ORCID ProfileAndrew C. Heath, View ORCID ProfileVictor Hesselbrock, View ORCID ProfileJohn K. Hewitt, View ORCID ProfileChristian Hopfer, View ORCID ProfileJohn Horwood, William Iacono, View ORCID ProfileEric O. Johnson, View ORCID ProfileJaakko A. Kaprio, View ORCID ProfileVictor Karpyak, View ORCID ProfileKenneth S. Kendler, View ORCID ProfileHenry R. Kranzler, View ORCID ProfileKenneth Krauter, View ORCID ProfilePaul Lichtenstein, View ORCID ProfilePenelope A. Lind, Matt McGue, View ORCID ProfileJames MacKillop, View ORCID ProfilePamela A.F. Madden, View ORCID ProfileHermine Maes, View ORCID ProfilePatrik Magnusson, View ORCID ProfileNicholas G. Martin, View ORCID ProfileSarah E. Medland, View ORCID ProfileGrant W. Montgomery, View ORCID ProfileElliot C. Nelson, View ORCID ProfileMarkus Nöthen, View ORCID ProfileAbraham A. Palmer, View ORCID ProfileNancy L. Pedersen, View ORCID ProfileBrenda W.J.H. Penninx, View ORCID ProfileBernice Porjesz, View ORCID ProfileJohn P. Rice, View ORCID ProfileMarcella Rietschel, View ORCID ProfileBrien P. Riley, Richard Rose, View ORCID ProfileDan Rujescu, Pei-Hong Shen, Judy Silberg, View ORCID ProfileMichael C. Stallings, View ORCID ProfileRalph E. Tarter, View ORCID ProfileMichael M. Vanyukov, Scott Vrieze, View ORCID ProfileTamara L. Wall, View ORCID ProfileJohn B. Whitfield, View ORCID ProfileHongyu Zhao, View ORCID ProfileBenjamin M. Neale, View ORCID ProfileJoel Gelernter, View ORCID ProfileHoward J. Edenberg, View ORCID ProfileArpana Agrawal
doi: https://doi.org/10.1101/257311
Raymond K. Walters
1Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
Mark J. Adams
2University of Edinburgh, Division of Psychiatry
Amy E. Adkins
3Department of Psychology & College Behavioral and Emotional Health Institute, Virginia Commonwealth University
Fazil Aliev
4Virginia Commonwealth University, Department of Psychology
Silviu-Alin Bacanu
5Virginia Commonwealth University Alcohol Research Center; Virginia Institute for Psychiatric and Behavioral Genetics; Department of Psychiatry, Virginia Commonwealth University
Anthony Batzler
6Mayo Clinic, Psychiatric Genomics and Pharmacogenomics Program
Sarah Bertelsen
5Virginia Commonwealth University Alcohol Research Center; Virginia Institute for Psychiatric and Behavioral Genetics; Department of Psychiatry, Virginia Commonwealth University
Joanna Biernacka
4Virginia Commonwealth University, Department of Psychology
Tim B. Bigdeli
6Mayo Clinic, Psychiatric Genomics and Pharmacogenomics Program
Li-Shiun Chen
10Washington University School of Medicine, Department of Psychiatry
Toni-Kim Clarke
2University of Edinburgh, Division of Psychiatry
Yi-Ling Chou
10Washington University School of Medicine, Department of Psychiatry
Franziska Degenhardt
11Institute of Human Genetics, University of Bonn; and Department of Genomics, Life & Brain Center, University of Bonn
Anna R. Docherty
12University of Utah, Department of Psychiatry
Pierre Fontanillas
1323andMe, Inc.
Jerome Foo
14Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University
Louis Fox
10Washington University School of Medicine, Department of Psychiatry
Josef Frank
14Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University
Ina Giegling
15Martin-Luther-University Halle-Wittenberg, Department of Psychiatry, Psychotherapy and Psychosomatics
Scott Gordon
16QIMR Berghofer Medical Research Institute
Laura M. Hack
17Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine
Annette M. Hartmann
15Martin-Luther-University Halle-Wittenberg, Department of Psychiatry, Psychotherapy and Psychosomatics
Sarah M. Hartz
10Washington University School of Medicine, Department of Psychiatry
Stefanie Heilmann-Heimbach
11Institute of Human Genetics, University of Bonn; and Department of Genomics, Life & Brain Center, University of Bonn
Stefan Herms
11Institute of Human Genetics, University of Bonn; and Department of Genomics, Life & Brain Center, University of Bonn
18Human Genomics Research Group, Department of Biomedicine, University of Basel Institute of Medical Genetics and Pathology, University Hospital Basel
Colin Hodgkinson
19NIH/NIAAA, Laboratory of Neurogenetics, NIAAA, NIH, USA
Per Hoffmann
11Institute of Human Genetics, University of Bonn; and Department of Genomics, Life & Brain Center, University of Bonn
18Human Genomics Research Group, Department of Biomedicine, University of Basel Institute of Medical Genetics and Pathology, University Hospital Basel
Jouke-Jan Hottenga
20Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands
Martin A. Kennedy
21University of Otago, Christchurch, New Zealand
Mervi Alanne-Kinnunen
22Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland
Bettina Konte
15Martin-Luther-University Halle-Wittenberg, Department of Psychiatry, Psychotherapy and Psychosomatics
Jari Lahti
23Helsinki Collegium for Advanced Studies, University of Helsinki, Helsinki, Finland
24Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland
Marius Lahti-Pulkkinen
24Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland
Lannie Ligthart
20Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands
Anu-Maria Loukola
22Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland
Brion S. Maher
25Johns Hopkins Bloomberg School of Public Health
Hamdi Mbarek
20Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands
Andrew M. McIntosh
26University of Edinburgh, Division of Psychiatry; Centre for Cognitive Ageing and Cognitive Epidemiology
Matthew B. McQueen
27Department of Integrative Physiology, University of Colorado Boulder
Yuri Milaneschi
28Department of Psychiatry, Amsterdam Public Health Research Institute, VU University Medical Center/GGz inGeest, Amsterdam, the Netherlands
Teemu Palviainen
22Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland
John F. Pearson
29Biostatistics and Computational Biology Unit, University of Otago, Christchurch, New Zealand
Roseann E. Peterson
30Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry
Renato Polimanti
31Department of Psychiatry, Yale School of Medicine and VA CT Healthcare Center, West Haven, CT, USA
Samuli Ripatti
22Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland
Euijung Ryu
32Mayo Clinic, Department of Health Sciences Research
Nancy L. Saccone
33Washington University School of Medicine, Department of Genetics
Jessica E. Salvatore
4Virginia Commonwealth University, Department of Psychology
30Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry
Sandra Sanchez-Roige
34University of California San Diego, Department of Psychiatry
Melanie Schwandt
35NIH/NIAAA, Office of the Clinical Director
Richard Sherva
36Department of Medicine (Biomedical Genetics), Boston University School of Medicine
Fabian Streit
14Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University
Jana Strohmaier
14Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University
Nathaniel Thomas
3Department of Psychology & College Behavioral and Emotional Health Institute, Virginia Commonwealth University
Jen-Chyong Wang
7Icahn School of Medicine at Mount Sinai, Department of Neuroscience
Bradley T. Webb
5Virginia Commonwealth University Alcohol Research Center; Virginia Institute for Psychiatric and Behavioral Genetics; Department of Psychiatry, Virginia Commonwealth University
Robbee Wedow
37Institute of Behavioral Science and Department of Sociology, University of Colorado
Leah Wetherill
38Indiana University School of Medicine, Department of Medical and Molecular Genetics
Amanda G. Wills
39University of Colorado School of Medicine, Department of Pharmacology
1323andMe, Inc.
Jason D. Boardman
37Institute of Behavioral Science and Department of Sociology, University of Colorado
Danfeng Chen
40Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
Doo-Sup Choi
41Mayo Clinic, Department of Molecular Pharmacology and Experimental Therapeutics
William E. Copeland
42Duke University Medical Center, Department of Psychiatry and Behavioral Sciences
Robert C. Culverhouse
43Washington University School of Medicine, Department of Medicine and Division of Biostatistics
Norbert Dahmen
44Department of Psychiatry, University of Mainz
Louisa Degenhardt
45National Drug and Alcohol Research Centre, University of New South Wales
Benjamin W. Domingue
46Stanford University Graduate School of Education
Sarah L. Elson
1323andMe, Inc.
Mark Frye
47Mayo Clinic, Department of Psychiatry and Psychology
Wolfgang Gäbel
48Department of Psychiatry and Psychotherapy, University of Düsseldorf
Marcus Ising
49Max-Planck-Institute of Psychiatry
Emma C. Johnson
10Washington University School of Medicine, Department of Psychiatry
Margaret Keyes
50University of Minnesota, Department of Psycholog
Falk Kiefer
51Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University
John Kramer
52University of Iowa Roy J and Lucille A Carver College of Medicine, Department of Psychiatry
Samuel Kuperman
52University of Iowa Roy J and Lucille A Carver College of Medicine, Department of Psychiatry
Susanne Lucae
49Max-Planck-Institute of Psychiatry
Michael T. Lynskey
53Addictions Dept, Institute of Psychiatry, Psychology & Neuroscience, King’s College London
Wolfgang Maier
54Department of Psychiatry, University of Bonn
Karl Mann
51Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University
Satu Männistö
55Institute for Health and Welfare, Finland
Jeanette Nance McClintick
56Indiana University School of Medicine, Biochemistry/Molecular Biology
Jacquelyn L. Meyers
57Henri Begleiter Neurodynamics Laboratory, Department of Psychiatry and Behavioral Sciences, SUNY Downstate Medical Center
Bertram Müller-Myhsok
58Department of Statistical Genetics, Max-Planck-Institute of Psychiatry
John I. Nurnberger
38Indiana University School of Medicine, Department of Medical and Molecular Genetics
59Department of Psychiatry, Indiana University School of Medicine
Aarno Palotie
1Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
22Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland
60Department of Medicine, Department of Neurology and Department of Psychiatry Massachusetts General Hospital, Boston, MA, USA
Ulrich Preuss
15Martin-Luther-University Halle-Wittenberg, Department of Psychiatry, Psychotherapy and Psychosomatics
61Vitos Hospital Herborn, Dept. of Psychiatry and Psychotherapy, Herborn
Katri Räikkönen
24Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland
Maureen D. Reynolds
62University of Pittsburgh, School of Pharmacy
Monika Ridinger
63Department of Psychiatry and Psychotherapy, University of Regensburg Psychiatric Health Care Aargau
Norbert Scherbaum
64LVR-Hospital Essen, Department of Psychiatry and Psychotherapy, Department of Addictive Behaviour and Addiction Medicine, Medical Faculty, University of Duisburg-Essen
Marc Shuckit
34University of California San Diego, Department of Psychiatry
Michael Soyka
65Medical Park Chiemseeblick in Bernau-Felden
66Psychiatric Hospital, Ludwig-Maximilians-University
Jens Treutlein
14Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University
Stephanie Witt
14Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University
Norbert Wodarz
67Department of Psychiatry and Psychotherapy, University of Regensburg
Peter Zill
66Psychiatric Hospital, Ludwig-Maximilians-University
Daniel E. Adkins
12University of Utah, Department of Psychiatry
68University of Utah, Department of Sociology
Joseph M. Boden
21University of Otago, Christchurch, New Zealand
Dorret Boomsma
20Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands
Laura J Bierut
10Washington University School of Medicine, Department of Psychiatry
Sandra A. Brown
34University of California San Diego, Department of Psychiatry
69University of California, San Diego School of Medicine, Department of Psychology
Kathleen K. Bucholz
10Washington University School of Medicine, Department of Psychiatry
Sven Cichon
18Human Genomics Research Group, Department of Biomedicine, University of Basel Institute of Medical Genetics and Pathology, University Hospital Basel
E. Jane Costello
42Duke University Medical Center, Department of Psychiatry and Behavioral Sciences
Harriet de Wit
70University of Chicago, Department of Psychiatry and Behavioral Neuroscience
Nancy Diazgranados
71NIAAA Intramural Research Program
Danielle M. Dick
3Department of Psychology & College Behavioral and Emotional Health Institute, Virginia Commonwealth University
72Department of Human & Molecular Genetics, Virginia Commonwealth University
Johan G. Eriksson
73Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland and National Institute for Health and Welfare, Finland
Lindsay A. Farrer
36Department of Medicine (Biomedical Genetics), Boston University School of Medicine
74Departments of Neurology, Ophthalmology, Epidemiology, and Biostatistics, Boston University Schools of Medicine and Public Health
Tatiana M. Foroud
38Indiana University School of Medicine, Department of Medical and Molecular Genetics
Nathan A. Gillespie
30Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry
Alison A. Goate
7Icahn School of Medicine at Mount Sinai, Department of Neuroscience
David Goldman
19NIH/NIAAA, Laboratory of Neurogenetics, NIAAA, NIH, USA
Richard A. Grucza
10Washington University School of Medicine, Department of Psychiatry
Dana B. Hancock
77University of Connecticut School of Medicine, Department of Psychiatry
Kathleen Mullan Harris
78University of Colorado Boulder, Institute for Behavioral Genetics
Andrew C. Heath
79University of Colorado Denver, School of Medicine
Victor Hesselbrock
21University of Otago, Christchurch, New Zealand
John K. Hewitt
78University of Colorado Boulder, Institute for Behavioral Genetics
Christian Hopfer
79University of Colorado Denver, School of Medicine
John Horwood
21University of Otago, Christchurch, New Zealand
William Iacono
50University of Minnesota, Department of Psycholog
Eric O. Johnson
80RTI International, Fellows Program
Jaakko A. Kaprio
22Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland
81Department of Public Health, University of Helsinki, Helsinki, Finland
Victor Karpyak
47Mayo Clinic, Department of Psychiatry and Psychology
Kenneth S. Kendler
5Virginia Commonwealth University Alcohol Research Center; Virginia Institute for Psychiatric and Behavioral Genetics; Department of Psychiatry, Virginia Commonwealth University
Henry R. Kranzler
82University of Pennsylvania Perelman School of Medicine, Center for Studies of Addiction, Department of Psychiatry and VISN 4 MIRECC, Crescenz VAMC
Kenneth Krauter
83University of Colorado Boulder, Department of Molecular, Cellular, and Developmental Biology
Paul Lichtenstein
84Department of Medical Epidemiology and Biostatistics, Karolinska Instituet, Stockholm, Sweden
Penelope A. Lind
16QIMR Berghofer Medical Research Institute
Matt McGue
50University of Minnesota, Department of Psycholog
James MacKillop
85Peter Boris Centre for Addictions Research, McMaster University/St. Joseph’s Healthcare Hamilton; Michael G. DeGroote Centre for Medicinal Cannabis Research
Pamela A.F. Madden
84Department of Medical Epidemiology and Biostatistics, Karolinska Instituet, Stockholm, Sweden
Hermine Maes
16QIMR Berghofer Medical Research Institute
Patrik Magnusson
84Department of Medical Epidemiology and Biostatistics, Karolinska Instituet, Stockholm, Sweden
Nicholas G. Martin
16QIMR Berghofer Medical Research Institute
Sarah E. Medland
16QIMR Berghofer Medical Research Institute
Grant W. Montgomery
87The Institute for Molecular Bioscience, University of Queensland
Elliot C. Nelson
10Washington University School of Medicine, Department of Psychiatry
Markus Nöthen
88Institute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn
Abraham A. Palmer
34University of California San Diego, Department of Psychiatry
89University of California San Diego, Institute for Genomic Medicine
Nancy L. Pedersen
84Department of Medical Epidemiology and Biostatistics, Karolinska Instituet, Stockholm, Sweden
Brenda W.J.H. Penninx
28Department of Psychiatry, Amsterdam Public Health Research Institute, VU University Medical Center/GGz inGeest, Amsterdam, the Netherlands
Bernice Porjesz
57Henri Begleiter Neurodynamics Laboratory, Department of Psychiatry and Behavioral Sciences, SUNY Downstate Medical Center
John P. Rice
10Washington University School of Medicine, Department of Psychiatry
Marcella Rietschel
14Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University
Brien P. Riley
5Virginia Commonwealth University Alcohol Research Center; Virginia Institute for Psychiatric and Behavioral Genetics; Department of Psychiatry, Virginia Commonwealth University
Richard Rose
90Department of Psychological & Brain Sciences, Indiana University, Bloomington, IN
Dan Rujescu
15Martin-Luther-University Halle-Wittenberg, Department of Psychiatry, Psychotherapy and Psychosomatics
Pei-Hong Shen
19NIH/NIAAA, Laboratory of Neurogenetics, NIAAA, NIH, USA
Judy Silberg
30Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry
Michael C. Stallings
78University of Colorado Boulder, Institute for Behavioral Genetics
Ralph E. Tarter
62University of Pittsburgh, School of Pharmacy
Michael M. Vanyukov
62University of Pittsburgh, School of Pharmacy
Scott Vrieze
50University of Minnesota, Department of Psycholog
Tamara L. Wall
34University of California San Diego, Department of Psychiatry
John B. Whitfield
16QIMR Berghofer Medical Research Institute
Hongyu Zhao
91Department of Biostatistics, Yale School of Public Health, Yale University
Benjamin M. Neale
1Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
Joel Gelernter
92Departments of Psychiatry, Genetics, and Neuroscience, Yale University School of Medicine; VA Connecticut Healthcare System
Howard J. Edenberg
38Indiana University School of Medicine, Department of Medical and Molecular Genetics
56Indiana University School of Medicine, Biochemistry/Molecular Biology
Arpana Agrawal
10Washington University School of Medicine, Department of Psychiatry
Abstract
Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic architecture or its genetic relationship with other disorders. To discover loci associated with AD and characterize the relationship between AD and other psychiatric and behavioral outcomes, we carried out the largest GWAS to date of DSM - IV diagnosed AD. Genome - wide data on 14,904 individuals with AD and 37,944 controls from 28 case / control and family - based studies were meta - analyzed, stratified by genetic ancestry (European, N = 46,568; African; N = 6,280). Independent, genome - wide significant effects of different ADH1B variants were identified in European (rs1229984; p = 9.8E - 13) and African ancestries (rs2066702; p = 2.2E - 9). Significant genetic correlations were observed with schizophrenia, ADHD, depression, and use of cigarettes and cannabis. There was only modest genetic correlation with alcohol consumption and inconsistent associations with problem drinking. The genetic underpinnings of AD only partially overlap with those for alcohol consumption, underscoring the genetic distinction between pathological and non - pathological drinking behaviors.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Posted March 10, 2018.
Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders
Raymond K. Walters, Mark J. Adams, Amy E. Adkins, Fazil Aliev, Silviu-Alin Bacanu, Anthony Batzler, Sarah Bertelsen, Joanna Biernacka, Tim B. Bigdeli, Li-Shiun Chen, Toni-Kim Clarke, Yi-Ling Chou, Franziska Degenhardt, Anna R. Docherty, Pierre Fontanillas, Jerome Foo, Louis Fox, Josef Frank, Ina Giegling, Scott Gordon, Laura M. Hack, Annette M. Hartmann, Sarah M. Hartz, Stefanie Heilmann-Heimbach, Stefan Herms, Colin Hodgkinson, Per Hoffmann, Jouke-Jan Hottenga, Martin A. Kennedy, Mervi Alanne-Kinnunen, Bettina Konte, Jari Lahti, Marius Lahti-Pulkkinen, Lannie Ligthart, Anu-Maria Loukola, Brion S. Maher, Hamdi Mbarek, Andrew M. McIntosh, Matthew B. McQueen, Yuri Milaneschi, Teemu Palviainen, John F. Pearson, Roseann E. Peterson, Renato Polimanti, Samuli Ripatti, Euijung Ryu, Nancy L. Saccone, Jessica E. Salvatore, Sandra Sanchez-Roige, Melanie Schwandt, Richard Sherva, Fabian Streit, Jana Strohmaier, Nathaniel Thomas, Jen-Chyong Wang, Bradley T. Webb, Robbee Wedow, Leah Wetherill, Amanda G. Wills, 23andMe Research Team, Jason D. Boardman, Danfeng Chen, Doo-Sup Choi, William E. Copeland, Robert C. Culverhouse, Norbert Dahmen, Louisa Degenhardt, Benjamin W. Domingue, Sarah L. Elson, Mark Frye, Wolfgang Gäbel, Marcus Ising, Emma C. Johnson, Margaret Keyes, Falk Kiefer, John Kramer, Samuel Kuperman, Susanne Lucae, Michael T. Lynskey, Wolfgang Maier, Karl Mann, Satu Männistö, Jeanette Nance McClintick, Jacquelyn L. Meyers, Bertram Müller-Myhsok, John I. Nurnberger, Aarno Palotie, Ulrich Preuss, Katri Räikkönen, Maureen D. Reynolds, Monika Ridinger, Norbert Scherbaum, Marc Shuckit, Michael Soyka, Jens Treutlein, Stephanie Witt, Norbert Wodarz, Peter Zill, Daniel E. Adkins, Joseph M. Boden, Dorret Boomsma, Laura J Bierut, Sandra A. Brown, Kathleen K. Bucholz, Sven Cichon, E. Jane Costello, Harriet de Wit, Nancy Diazgranados, Danielle M. Dick, Johan G. Eriksson, Lindsay A. Farrer, Tatiana M. Foroud, Nathan A. Gillespie, Alison A. Goate, David Goldman, Richard A. Grucza, Dana B. Hancock, Kathleen Mullan Harris, Andrew C. Heath, Victor Hesselbrock, John K. Hewitt, Christian Hopfer, John Horwood, William Iacono, Eric O. Johnson, Jaakko A. Kaprio, Victor Karpyak, Kenneth S. Kendler, Henry R. Kranzler, Kenneth Krauter, Paul Lichtenstein, Penelope A. Lind, Matt McGue, James MacKillop, Pamela A.F. Madden, Hermine Maes, Patrik Magnusson, Nicholas G. Martin, Sarah E. Medland, Grant W. Montgomery, Elliot C. Nelson, Markus Nöthen, Abraham A. Palmer, Nancy L. Pedersen, Brenda W.J.H. Penninx, Bernice Porjesz, John P. Rice, Marcella Rietschel, Brien P. Riley, Richard Rose, Dan Rujescu, Pei-Hong Shen, Judy Silberg, Michael C. Stallings, Ralph E. Tarter, Michael M. Vanyukov, Scott Vrieze, Tamara L. Wall, John B. Whitfield, Hongyu Zhao, Benjamin M. Neale, Joel Gelernter, Howard J. Edenberg, Arpana Agrawal
bioRxiv 257311; doi: https://doi.org/10.1101/257311
Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders
Raymond K. Walters, Mark J. Adams, Amy E. Adkins, Fazil Aliev, Silviu-Alin Bacanu, Anthony Batzler, Sarah Bertelsen, Joanna Biernacka, Tim B. Bigdeli, Li-Shiun Chen, Toni-Kim Clarke, Yi-Ling Chou, Franziska Degenhardt, Anna R. Docherty, Pierre Fontanillas, Jerome Foo, Louis Fox, Josef Frank, Ina Giegling, Scott Gordon, Laura M. Hack, Annette M. Hartmann, Sarah M. Hartz, Stefanie Heilmann-Heimbach, Stefan Herms, Colin Hodgkinson, Per Hoffmann, Jouke-Jan Hottenga, Martin A. Kennedy, Mervi Alanne-Kinnunen, Bettina Konte, Jari Lahti, Marius Lahti-Pulkkinen, Lannie Ligthart, Anu-Maria Loukola, Brion S. Maher, Hamdi Mbarek, Andrew M. McIntosh, Matthew B. McQueen, Yuri Milaneschi, Teemu Palviainen, John F. Pearson, Roseann E. Peterson, Renato Polimanti, Samuli Ripatti, Euijung Ryu, Nancy L. Saccone, Jessica E. Salvatore, Sandra Sanchez-Roige, Melanie Schwandt, Richard Sherva, Fabian Streit, Jana Strohmaier, Nathaniel Thomas, Jen-Chyong Wang, Bradley T. Webb, Robbee Wedow, Leah Wetherill, Amanda G. Wills, 23andMe Research Team, Jason D. Boardman, Danfeng Chen, Doo-Sup Choi, William E. Copeland, Robert C. Culverhouse, Norbert Dahmen, Louisa Degenhardt, Benjamin W. Domingue, Sarah L. Elson, Mark Frye, Wolfgang Gäbel, Marcus Ising, Emma C. Johnson, Margaret Keyes, Falk Kiefer, John Kramer, Samuel Kuperman, Susanne Lucae, Michael T. Lynskey, Wolfgang Maier, Karl Mann, Satu Männistö, Jeanette Nance McClintick, Jacquelyn L. Meyers, Bertram Müller-Myhsok, John I. Nurnberger, Aarno Palotie, Ulrich Preuss, Katri Räikkönen, Maureen D. Reynolds, Monika Ridinger, Norbert Scherbaum, Marc Shuckit, Michael Soyka, Jens Treutlein, Stephanie Witt, Norbert Wodarz, Peter Zill, Daniel E. Adkins, Joseph M. Boden, Dorret Boomsma, Laura J Bierut, Sandra A. Brown, Kathleen K. Bucholz, Sven Cichon, E. Jane Costello, Harriet de Wit, Nancy Diazgranados, Danielle M. Dick, Johan G. Eriksson, Lindsay A. Farrer, Tatiana M. Foroud, Nathan A. Gillespie, Alison A. Goate, David Goldman, Richard A. Grucza, Dana B. Hancock, Kathleen Mullan Harris, Andrew C. Heath, Victor Hesselbrock, John K. Hewitt, Christian Hopfer, John Horwood, William Iacono, Eric O. Johnson, Jaakko A. Kaprio, Victor Karpyak, Kenneth S. Kendler, Henry R. Kranzler, Kenneth Krauter, Paul Lichtenstein, Penelope A. Lind, Matt McGue, James MacKillop, Pamela A.F. Madden, Hermine Maes, Patrik Magnusson, Nicholas G. Martin, Sarah E. Medland, Grant W. Montgomery, Elliot C. Nelson, Markus Nöthen, Abraham A. Palmer, Nancy L. Pedersen, Brenda W.J.H. Penninx, Bernice Porjesz, John P. Rice, Marcella Rietschel, Brien P. Riley, Richard Rose, Dan Rujescu, Pei-Hong Shen, Judy Silberg, Michael C. Stallings, Ralph E. Tarter, Michael M. Vanyukov, Scott Vrieze, Tamara L. Wall, John B. Whitfield, Hongyu Zhao, Benjamin M. Neale, Joel Gelernter, Howard J. Edenberg, Arpana Agrawal
bioRxiv 257311; doi: https://doi.org/10.1101/257311
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