New Results
Genetic meta-analysis identifies 9 novel loci and functional pathways for Alzheimer’s disease risk
Iris E Jansen, Jeanne E Savage, Kyoko Watanabe, Julien Bryois, Dylan M Williams, Stacy Steinberg, Julia Sealock, Ida K Karlsson, Sara Hägg, Lavinia Athanasiu, Nicola Voyle, Petroula Proitsi, Aree Witoelar, Sven Stringer, Dag Aarsland, Ina S Almdahl, Fred Andersen, Sverre Bergh, Francesco Bettella, Sigurbjorn Bjornsson, Anne Brækhus, Geir Bråthen, Christiaan de Leeuw, Rahul S Desikan, Srdjan Djurovic, Logan Dumitrescu, Tormod Fladby, Timothy Homan, Palmi V Jonsson, Steven J Kiddle, K Arvid Rongve, Ingvild Saltvedt, Sigrid B. Sando, Geir Selbæk, Nathan Skenne, Jon Snaedal, Eystein Stordal, Ingun D. Ulstein, Yunpeng Wang, Linda R White, Jens Hjerling-Leffler, Patrick F Sullivan, Wiesje M van der Flier, Richard Dobson, Lea K. Davis, Hreinn Stefansson, Kari Stefansson, Nancy L Pedersen, Stephan Ripke, Ole A Andreassen, Danielle Posthuma
doi: https://doi.org/10.1101/258533
Iris E Jansen
1Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University, Amsterdam, The Netherlands
2Alzheimer Center and Department of Neurology, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands
Jeanne E Savage
1Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University, Amsterdam, The Netherlands
Kyoko Watanabe
1Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University, Amsterdam, The Netherlands
Julien Bryois
3Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Dylan M Williams
3Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Stacy Steinberg
4deCODE Genetics/Amgen, Reykjavik, Iceland
Julia Sealock
5Interdisciplinary Graduate Program, Vanderbilt University, Nashville, USA
Ida K Karlsson
3Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Sara Hägg
3Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Lavinia Athanasiu
6NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway
7Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway
Nicola Voyle
8Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
Petroula Proitsi
8Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
Aree Witoelar
6NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway
9Institute of Clinical Medicine, University of Oslo, Oslo, Norway
Sven Stringer
1Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University, Amsterdam, The Netherlands
Dag Aarsland
8Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
10Center for Age-Related Diseases, Stavanger University Hospital, Stavanger, Norway
Ina S Almdahl
11Department of Neurology, Akershus University Hospital, Lørenskog, Norway
13Department of Psychiatry of Old Age, Oslo University Hospital, Oslo, Norway
Fred Andersen
14Department of Community Medicine, University of Tromsø, Tromsø, Norway
Sverre Bergh
15Norwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway
16Centre for Old Age Psychiatry Research, Innlandet Hospital Trust, Ottestad, Norway
Francesco Bettella
6NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway
9Institute of Clinical Medicine, University of Oslo, Oslo, Norway
Sigurbjorn Bjornsson
17Department of Geriatric Medicine, Landspitali University Hospital, Reykjavik, Iceland
Anne Brækhus
15Norwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway
18Geriatric Department, University Hospital Oslo and University of Oslo, Oslo, Norway
Geir Bråthen
19Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway
20Department of Neurology, St Olav’s Hospital, Trondheim University Hospital, Trondheim, Norway
Christiaan de Leeuw
1Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University, Amsterdam, The Netherlands
Rahul S Desikan
21Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA
Srdjan Djurovic
6NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway
22Department of Medical Genetics, Oslo University Hospital, Oslo, Norway
Logan Dumitrescu
23Vanderbilt Memory & Alzheimer’s Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, USA
Tormod Fladby
11Department of Neurology, Akershus University Hospital, Lørenskog, Norway
12AHUS Campus, University of Oslo, Oslo, Norway
Timothy Homan
23Vanderbilt Memory & Alzheimer’s Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, USA
Palmi V Jonsson
17Department of Geriatric Medicine, Landspitali University Hospital, Reykjavik, Iceland
24Faculty of Medicine, University of Iceland, Reykjavik, Iceland
Steven J Kiddle
25MRC Biostatistics Unit, Cambridge Institute of Public Health, University of Cambridge, Cambridge, UK
K Arvid Rongve
27Department of Clinical Medicine, University of Bergen, Bergen, Norway
28Department of Geriatrics, St. Olav’s Hospital, Trondheim University Hospital, Trondheim, Norway
Ingvild Saltvedt
19Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway
28Department of Geriatrics, St. Olav’s Hospital, Trondheim University Hospital, Trondheim, Norway
Sigrid B. Sando
19Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway
20Department of Neurology, St Olav’s Hospital, Trondheim University Hospital, Trondheim, Norway
Geir Selbæk
15Norwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway
29Institute of Health and Society, University of Oslo, Oslo, Norway
Nathan Skenne
30Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
Jon Snaedal
17Department of Geriatric Medicine, Landspitali University Hospital, Reykjavik, Iceland
Eystein Stordal
31Department of Psychiatry, Namsos Hospital, Namsos, Norway
32Department of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway
Ingun D. Ulstein
33Memory Clinic, Geriatric Department, Oslo University Hospital, Oslo, Norway
Yunpeng Wang
6NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway
9Institute of Clinical Medicine, University of Oslo, Oslo, Norway
Linda R White
19Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway
20Department of Neurology, St Olav’s Hospital, Trondheim University Hospital, Trondheim, Norway
Jens Hjerling-Leffler
30Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
Patrick F Sullivan
3Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
34Department of Genetics, University of North Carolina, Chapel Hill, USA
35Department of Psychiatry, University of North Carolina, Chapel Hill, USA
Wiesje M van der Flier
2Alzheimer Center and Department of Neurology, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands
Richard Dobson
8Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
36Farr Institute of Health Informatics Research, University College London, London, UK
Lea K. Davis
37Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, US
38Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, US
Hreinn Stefansson
4deCODE Genetics/Amgen, Reykjavik, Iceland
Kari Stefansson
4deCODE Genetics/Amgen, Reykjavik, Iceland
Nancy L Pedersen
3Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Stephan Ripke
39Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, USA
41Dept. of Psychiatry and Psychotherapy, Charité - Universitätsmedizin, Berlin, Germany
Ole A Andreassen
6NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway
9Institute of Clinical Medicine, University of Oslo, Oslo, Norway
Danielle Posthuma
1Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University, Amsterdam, The Netherlands
42Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands
Posted February 22, 2018.
Genetic meta-analysis identifies 9 novel loci and functional pathways for Alzheimer’s disease risk
Iris E Jansen, Jeanne E Savage, Kyoko Watanabe, Julien Bryois, Dylan M Williams, Stacy Steinberg, Julia Sealock, Ida K Karlsson, Sara Hägg, Lavinia Athanasiu, Nicola Voyle, Petroula Proitsi, Aree Witoelar, Sven Stringer, Dag Aarsland, Ina S Almdahl, Fred Andersen, Sverre Bergh, Francesco Bettella, Sigurbjorn Bjornsson, Anne Brækhus, Geir Bråthen, Christiaan de Leeuw, Rahul S Desikan, Srdjan Djurovic, Logan Dumitrescu, Tormod Fladby, Timothy Homan, Palmi V Jonsson, Steven J Kiddle, K Arvid Rongve, Ingvild Saltvedt, Sigrid B. Sando, Geir Selbæk, Nathan Skenne, Jon Snaedal, Eystein Stordal, Ingun D. Ulstein, Yunpeng Wang, Linda R White, Jens Hjerling-Leffler, Patrick F Sullivan, Wiesje M van der Flier, Richard Dobson, Lea K. Davis, Hreinn Stefansson, Kari Stefansson, Nancy L Pedersen, Stephan Ripke, Ole A Andreassen, Danielle Posthuma
bioRxiv 258533; doi: https://doi.org/10.1101/258533
Genetic meta-analysis identifies 9 novel loci and functional pathways for Alzheimer’s disease risk
Iris E Jansen, Jeanne E Savage, Kyoko Watanabe, Julien Bryois, Dylan M Williams, Stacy Steinberg, Julia Sealock, Ida K Karlsson, Sara Hägg, Lavinia Athanasiu, Nicola Voyle, Petroula Proitsi, Aree Witoelar, Sven Stringer, Dag Aarsland, Ina S Almdahl, Fred Andersen, Sverre Bergh, Francesco Bettella, Sigurbjorn Bjornsson, Anne Brækhus, Geir Bråthen, Christiaan de Leeuw, Rahul S Desikan, Srdjan Djurovic, Logan Dumitrescu, Tormod Fladby, Timothy Homan, Palmi V Jonsson, Steven J Kiddle, K Arvid Rongve, Ingvild Saltvedt, Sigrid B. Sando, Geir Selbæk, Nathan Skenne, Jon Snaedal, Eystein Stordal, Ingun D. Ulstein, Yunpeng Wang, Linda R White, Jens Hjerling-Leffler, Patrick F Sullivan, Wiesje M van der Flier, Richard Dobson, Lea K. Davis, Hreinn Stefansson, Kari Stefansson, Nancy L Pedersen, Stephan Ripke, Ole A Andreassen, Danielle Posthuma
bioRxiv 258533; doi: https://doi.org/10.1101/258533
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