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GWAS identifies 10 loci for objectively-measured physical activity and sleep with causal roles in cardiometabolic disease

View ORCID ProfileAiden Doherty, Karl Smith-Byrne, Teresa Ferreira, View ORCID ProfileMichael V. Holmes, View ORCID ProfileChris Holmes, View ORCID ProfileSara L. Pulit, View ORCID ProfileCecilia M. Lindgren
doi: https://doi.org/10.1101/261719
Aiden Doherty
1Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, U.K.
2Nuffield Department of Population Health, BHF Centre of Research Excellence, University of Oxford, Oxford, U.K.
3Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, U.K.
4NIHR Oxford Biomedical Research Centre, Oxford University Hospital, Oxford, UK
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  • For correspondence: aiden.doherty@bdi.ox.ac.uk
Karl Smith-Byrne
5Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, U.K.
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Teresa Ferreira
1Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, U.K.
6Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
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Michael V. Holmes
4NIHR Oxford Biomedical Research Centre, Oxford University Hospital, Oxford, UK
7Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, U.K.
8Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, U.K.
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Chris Holmes
1Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, U.K.
9Department of Statistics, University of Oxford, Oxford, UK
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Sara L. Pulit
1Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, U.K.
6Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
10Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands
11Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA
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Cecilia M. Lindgren
1Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, U.K.
4NIHR Oxford Biomedical Research Centre, Oxford University Hospital, Oxford, UK
6Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
11Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA
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  • ORCID record for Cecilia M. Lindgren
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Article Information

doi 
https://doi.org/10.1101/261719
History 
  • February 8, 2018.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Aiden Doherty1,2,3,4,*,
  2. Karl Smith-Byrne5,
  3. Teresa Ferreira1,6,
  4. Michael V. Holmes4,7,8,
  5. Chris Holmes1,9,
  6. Sara L. Pulit1,6,10,11 and
  7. Cecilia M. Lindgren1,4,6,11
  1. 1Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, U.K.
  2. 2Nuffield Department of Population Health, BHF Centre of Research Excellence, University of Oxford, Oxford, U.K.
  3. 3Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, U.K.
  4. 4NIHR Oxford Biomedical Research Centre, Oxford University Hospital, Oxford, UK
  5. 5Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, U.K.
  6. 6Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
  7. 7Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, U.K.
  8. 8Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, U.K.
  9. 9Department of Statistics, University of Oxford, Oxford, UK
  10. 10Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands
  11. 11Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA
  1. ↵*Corresponding author. E-mail: aiden.doherty{at}bdi.ox.ac.uk
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Posted February 08, 2018.
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GWAS identifies 10 loci for objectively-measured physical activity and sleep with causal roles in cardiometabolic disease
Aiden Doherty, Karl Smith-Byrne, Teresa Ferreira, Michael V. Holmes, Chris Holmes, Sara L. Pulit, Cecilia M. Lindgren
bioRxiv 261719; doi: https://doi.org/10.1101/261719
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GWAS identifies 10 loci for objectively-measured physical activity and sleep with causal roles in cardiometabolic disease
Aiden Doherty, Karl Smith-Byrne, Teresa Ferreira, Michael V. Holmes, Chris Holmes, Sara L. Pulit, Cecilia M. Lindgren
bioRxiv 261719; doi: https://doi.org/10.1101/261719

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