GWAS identifies 10 loci for objectively-measured physical activity and sleep with causal roles in cardiometabolic disease

Aiden Doherty; Karl Smith-Byrne; Teresa Ferreira; Michael V. Holmes; Chris Holmes; Sara L. Pulit; Cecilia M. Lindgren

doi:10.1101/261719

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GWAS identifies 10 loci for objectively-measured physical activity and sleep with causal roles in cardiometabolic disease

View ORCID ProfileAiden Doherty, Karl Smith-Byrne, Teresa Ferreira, View ORCID ProfileMichael V. Holmes, View ORCID ProfileChris Holmes, View ORCID ProfileSara L. Pulit, View ORCID ProfileCecilia M. Lindgren

doi: https://doi.org/10.1101/261719

Aiden Doherty

Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, U.K.Nuffield Department of Population Health, BHF Centre of Research Excellence, University of Oxford, Oxford, U.K.Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, U.K.NIHR Oxford Biomedical Research Centre, Oxford University Hospital, Oxford, UK

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For correspondence: aiden.doherty@bdi.ox.ac.uk

Karl Smith-Byrne

Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, U.K.

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Teresa Ferreira

Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, U.K.Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK

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Michael V. Holmes

NIHR Oxford Biomedical Research Centre, Oxford University Hospital, Oxford, UKClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, U.K.Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, U.K.

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Chris Holmes

Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, U.K.Department of Statistics, University of Oxford, Oxford, UK

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Sara L. Pulit

Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, U.K.Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UKDepartment of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the NetherlandsProgram in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA

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Cecilia M. Lindgren

Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, U.K.NIHR Oxford Biomedical Research Centre, Oxford University Hospital, Oxford, UKWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UKProgram in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA

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