Abstract
Methyl-IT, a novel methylome analysis procedure based on information thermodynamics and signal detection was recently released. Methylation analysis involves a signal detection problem, and the method was designed to discriminate methylation regulatory signal from background noise induced by thermal fluctuations. Methyl-IT enhances the resolution of genome methylation behavior to reveal network-associated responses, offering resolution of gene pathway influences not attainable with previous methods. Herein, an example of MethylIT application to the analysis of breast cancer methylomes is presented.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.