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Properties of Gene Expression and Chromatin Structure with Mechanically Regulated Transcription

Stuart A Sevier, Herbert Levine
doi: https://doi.org/10.1101/262717
Stuart A Sevier
Rice University, CTBP
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  • For correspondence: s.a.sevier@gmail.com
Herbert Levine
Rice University, CTBP
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Abstract

The mechanical properties of transcription have emerged as central elements in our understanding of gene expression. Recent work has been done introducing a simple description of the basic physical elements of transcription where RNA elongation, RNA polymerase (RNAP) rotation and DNA supercoiling are coupled. Here we generalize this framework to accommodate the behavior of many RNAPs operating on multiple genes on a shared piece of DNA. The resulting framework is combined with well-established stochastic processes of transcription resulting in a model which characterizes the impact of the mechanical properties of transcription on gene expression and DNA structure. Transcriptional bursting readily emerges as a common phenomenon with origins in the geometric nature of the genetic system and results in the bounding of gene expression statistics. Properties of a multiple gene system are examined with special attention paid to role that genome composition (gene orientation, size, and intergenic distance) plays in the ability of genes to transcribe. The role of transcription in shaping DNA structure is examined and the possibility of transcription driven domain formation is discussed.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted February 10, 2018.
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Properties of Gene Expression and Chromatin Structure with Mechanically Regulated Transcription
Stuart A Sevier, Herbert Levine
bioRxiv 262717; doi: https://doi.org/10.1101/262717
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Properties of Gene Expression and Chromatin Structure with Mechanically Regulated Transcription
Stuart A Sevier, Herbert Levine
bioRxiv 262717; doi: https://doi.org/10.1101/262717

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