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Subtle left-right asymmetry of gene expression profiles in embryonic and foetal human brains

View ORCID ProfileCarolien G.F. de Kovel, View ORCID ProfileSteven N. Lisgo, Simon E. Fisher, View ORCID ProfileClyde Francks
doi: https://doi.org/10.1101/263111
Carolien G.F. de Kovel
1Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands
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  • ORCID record for Carolien G.F. de Kovel
Steven N. Lisgo
2Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
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Simon E. Fisher
1Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands
3Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands
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Clyde Francks
1Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands
3Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands
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Abstract

Left-right laterality is an important aspect of human brain organization for which the genetic basis is poorly understood. Using RNA sequencing data we contrasted gene expression in left- and right-sided samples from several structures of the anterior central nervous systems of post mortem human embryos and fetuses. While few individual genes stood out as significantly lateralized, most structures showed evidence of laterality of their overall transcriptomic profiles. These left-right differences showed overlap with age-dependent changes in expression, indicating lateralized maturation rates, but not consistently in left-right orientation over all structures. Brain asymmetry may therefore originate in multiple locations, or if there is a single origin, it is earlier than 5 weeks post conception, with structure-specific lateralized processes already underway by this age. This pattern is broadly consistent with the weak correlations reported between various aspects of adult brain laterality, such as language dominance and handedness.

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Posted February 09, 2018.
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Subtle left-right asymmetry of gene expression profiles in embryonic and foetal human brains
Carolien G.F. de Kovel, Steven N. Lisgo, Simon E. Fisher, Clyde Francks
bioRxiv 263111; doi: https://doi.org/10.1101/263111
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Subtle left-right asymmetry of gene expression profiles in embryonic and foetal human brains
Carolien G.F. de Kovel, Steven N. Lisgo, Simon E. Fisher, Clyde Francks
bioRxiv 263111; doi: https://doi.org/10.1101/263111

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