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Competitive release in tumors

Yongqian Ma, Jeffrey West, Paul K. Newton
doi: https://doi.org/10.1101/263335
Yongqian Ma
Department of Physics & Astronomy, University of Southern California, CA 90089 (e-mail: ).
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  • For correspondence: yongqiam@usc.edu
Jeffrey West
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Paul K. Newton
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Abstract

Competitive release is a bedrock principle of coevolutionary ecology and population dynamics. It is also the main mechanism by which heterogeneous tumors develop chemotherapeutic resistance. Understanding, controlling, and exploiting this important mechanism represents one of the key challenges and potential opportunities of current medical oncology. The development of sophisticated mathematical and computational models of coevolution among clonal and sub-clonal cell populations in the tumor ecosystem can guide us in predicting and shaping various responses to perturbations in the fitness landscape which is altered by chemo-toxic agents. This in turn can help us design adaptive chemotherapeutic strategies to combat the release resistant cells.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted February 10, 2018.
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Competitive release in tumors
Yongqian Ma, Jeffrey West, Paul K. Newton
bioRxiv 263335; doi: https://doi.org/10.1101/263335
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Competitive release in tumors
Yongqian Ma, Jeffrey West, Paul K. Newton
bioRxiv 263335; doi: https://doi.org/10.1101/263335

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