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Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP pathways in macrophages
Evan D. Muse, Shan Yu, Chantle R. Edillor, Jenhan Tao, Nathanael J. Spann, Ty D. Troutman, Jason S. Seidman, Adam Henke, Jason T. Roland, Katherine A. Ozeki, Jeffrey G. McDonald, John Bahadorani, Sotirios Tsimikas, Tamar R. Grossman, Matthew S. Tremblay, Christopher K. Glass
doi: https://doi.org/10.1101/263434
Evan D. Muse
1Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093
2Scripps Translational Science Institute, Division of Cardiology, Scripps Health, La Jolla, CA 92037
Shan Yu
3California Institute for Biomedical Research (Calibr), La Jolla, CA 92037
Chantle R. Edillor
1Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093
Jenhan Tao
1Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093
Nathanael J. Spann
1Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093
Ty D. Troutman
1Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093
Jason S. Seidman
1Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093
Adam Henke
3California Institute for Biomedical Research (Calibr), La Jolla, CA 92037
Jason T. Roland
3California Institute for Biomedical Research (Calibr), La Jolla, CA 92037
Katherine A. Ozeki
1Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093
Jeffrey G. McDonald
4Department of Molecular Genetics, The University of Texas Southwestern Medical Center, Dallas, TX 75390
John Bahadorani
5Department of Medicine, University of California, San Diego, La Jolla, CA 92093
Sotirios Tsimikas
5Department of Medicine, University of California, San Diego, La Jolla, CA 92093
Tamar R. Grossman
6Ionis Pharmaceuticals, Carlsbad, CA 92008
Matthew S. Tremblay
3California Institute for Biomedical Research (Calibr), La Jolla, CA 92037
Christopher K. Glass
1Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093
5Department of Medicine, University of California, San Diego, La Jolla, CA 92093
Posted February 11, 2018.
Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP pathways in macrophages
Evan D. Muse, Shan Yu, Chantle R. Edillor, Jenhan Tao, Nathanael J. Spann, Ty D. Troutman, Jason S. Seidman, Adam Henke, Jason T. Roland, Katherine A. Ozeki, Jeffrey G. McDonald, John Bahadorani, Sotirios Tsimikas, Tamar R. Grossman, Matthew S. Tremblay, Christopher K. Glass
bioRxiv 263434; doi: https://doi.org/10.1101/263434
Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP pathways in macrophages
Evan D. Muse, Shan Yu, Chantle R. Edillor, Jenhan Tao, Nathanael J. Spann, Ty D. Troutman, Jason S. Seidman, Adam Henke, Jason T. Roland, Katherine A. Ozeki, Jeffrey G. McDonald, John Bahadorani, Sotirios Tsimikas, Tamar R. Grossman, Matthew S. Tremblay, Christopher K. Glass
bioRxiv 263434; doi: https://doi.org/10.1101/263434
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