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Evidence of a common causal relationship between body mass index and inflammatory skin disease: a Mendelian Randomization study
View ORCID ProfileAshley Budu-Aggrey, View ORCID ProfileBen Brumpton, View ORCID ProfileJess Tyrrell, View ORCID ProfileSarah Watkins, View ORCID ProfileEllen H Modalsli, View ORCID ProfileCarlos Celis-Morales, View ORCID ProfileLyn D Ferguson, Gunnhild Åberge Vie, View ORCID ProfileTom Palmer, View ORCID ProfileLars G Fritsche, Mari Løset, View ORCID ProfileJonas Bille Nielsen, Wei Zhou, Lam C Tsoi, Andrew R Wood, Samuel E Jones, View ORCID ProfileRobin Beaumont, Marit Saunes, View ORCID ProfilePål Richard Romundstad, Stefan Siebert, View ORCID ProfileIain B McInnes, James T Elder, George Davey Smith, View ORCID ProfileTimothy M Frayling, Bjørn Olav Åsvold, Sara J Brown, Naveed Sattar, View ORCID ProfileLavinia Paternoster
doi: https://doi.org/10.1101/265629
Ashley Budu-Aggrey
1Medical Research Council (MRC) Integrative Epidemiology Unit, University of Bristol, Bristol, UK
2Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, UK
*These authors contributed equally to this work.
Ben Brumpton
1Medical Research Council (MRC) Integrative Epidemiology Unit, University of Bristol, Bristol, UK
3K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway
4Department of Thoracic Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway
*These authors contributed equally to this work.
Jess Tyrrell
5Genetics of Complex Traits, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, UK
6European Centre for Environment and Human Health, University of Exeter Medical School, The Knowledge Spa, Truro, UK
*These authors contributed equally to this work.
Sarah Watkins
1Medical Research Council (MRC) Integrative Epidemiology Unit, University of Bristol, Bristol, UK
2Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, UK
*These authors contributed equally to this work.
Ellen H Modalsli
7Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway
8Department of Dermatology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway
Carlos Celis-Morales
9Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
Lyn D Ferguson
9Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
Gunnhild Åberge Vie
7Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway
Tom Palmer
10Department of Mathematics and Statistics, Lancaster University, Lancaster, UK
Lars G Fritsche
3K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway
Mari Løset
3K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway
8Department of Dermatology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway
Jonas Bille Nielsen
11Department of Internal Medicine, Division of Cardiology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
Wei Zhou
12Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States of America
Lam C Tsoi
13Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA
14Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA
Andrew R Wood
5Genetics of Complex Traits, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, UK
Samuel E Jones
5Genetics of Complex Traits, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, UK
Robin Beaumont
5Genetics of Complex Traits, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, UK
Marit Saunes
8Department of Dermatology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway
15Department of Clinical and Molecular Medicine, NTNU, Norwegian University of Science and Technology, Trondheim, Norway
Pål Richard Romundstad
7Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway
Stefan Siebert
16Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK
Iain B McInnes
16Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK
James T Elder
13Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA
17Ann Arbor Veterans Affairs Hospital, Ann Arbor, Michigan, USA
George Davey Smith
1Medical Research Council (MRC) Integrative Epidemiology Unit, University of Bristol, Bristol, UK
2Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, UK
Timothy M Frayling
5Genetics of Complex Traits, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, UK
**Joint last authors.
Bjørn Olav Åsvold
3K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway
18Department of Endocrinology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway
**Joint last authors.
Sara J Brown
19Skin Research Group, School of Medicine, University of Dundee, Dundee, UK
20Department of Dermatology, Ninewells Hospital and Medical School, Dundee, UK
**Joint last authors.
Naveed Sattar
9Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
**Joint last authors.
Lavinia Paternoster
1Medical Research Council (MRC) Integrative Epidemiology Unit, University of Bristol, Bristol, UK
2Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, UK
**Joint last authors.
Article usage
Posted February 15, 2018.
Evidence of a common causal relationship between body mass index and inflammatory skin disease: a Mendelian Randomization study
Ashley Budu-Aggrey, Ben Brumpton, Jess Tyrrell, Sarah Watkins, Ellen H Modalsli, Carlos Celis-Morales, Lyn D Ferguson, Gunnhild Åberge Vie, Tom Palmer, Lars G Fritsche, Mari Løset, Jonas Bille Nielsen, Wei Zhou, Lam C Tsoi, Andrew R Wood, Samuel E Jones, Robin Beaumont, Marit Saunes, Pål Richard Romundstad, Stefan Siebert, Iain B McInnes, James T Elder, George Davey Smith, Timothy M Frayling, Bjørn Olav Åsvold, Sara J Brown, Naveed Sattar, Lavinia Paternoster
bioRxiv 265629; doi: https://doi.org/10.1101/265629
Evidence of a common causal relationship between body mass index and inflammatory skin disease: a Mendelian Randomization study
Ashley Budu-Aggrey, Ben Brumpton, Jess Tyrrell, Sarah Watkins, Ellen H Modalsli, Carlos Celis-Morales, Lyn D Ferguson, Gunnhild Åberge Vie, Tom Palmer, Lars G Fritsche, Mari Løset, Jonas Bille Nielsen, Wei Zhou, Lam C Tsoi, Andrew R Wood, Samuel E Jones, Robin Beaumont, Marit Saunes, Pål Richard Romundstad, Stefan Siebert, Iain B McInnes, James T Elder, George Davey Smith, Timothy M Frayling, Bjørn Olav Åsvold, Sara J Brown, Naveed Sattar, Lavinia Paternoster
bioRxiv 265629; doi: https://doi.org/10.1101/265629
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