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tarsal-less is expressed as a gap gene but has no gap gene phenotype in the moth midge Clogmia albipunctata

View ORCID ProfileEva Jiménez-Guri, View ORCID ProfileKarl R. Wotton, View ORCID ProfileJohannes Jaeger
doi: https://doi.org/10.1101/266288
Eva Jiménez-Guri
aEMBL/CRG Research Unit in Systems Biology, Centre de Regulació Genòmica (CRG), The Barcelona Institute of Science and Technology (BIST), Dr. Aiguader 88, 08003 Barcelona, Spain
bUniversitat Pompeu Fabra (UPF), Barcelona, Spain
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  • For correspondence: E.Jimenez-Guri@exeter.ac.uk
Karl R. Wotton
aEMBL/CRG Research Unit in Systems Biology, Centre de Regulació Genòmica (CRG), The Barcelona Institute of Science and Technology (BIST), Dr. Aiguader 88, 08003 Barcelona, Spain
bUniversitat Pompeu Fabra (UPF), Barcelona, Spain
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Johannes Jaeger
aEMBL/CRG Research Unit in Systems Biology, Centre de Regulació Genòmica (CRG), The Barcelona Institute of Science and Technology (BIST), Dr. Aiguader 88, 08003 Barcelona, Spain
bUniversitat Pompeu Fabra (UPF), Barcelona, Spain
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Abstract

Gap genes are involved in segment determination during early development of the vinegar fly Drosophila melanogaster and other dipteran insects (flies, midges, and mosquitoes). They are expressed in overlapping domains along the antero-posterior (A–P) axis of the blastoderm embryo. While gap domains cover the entire length of the A–P axis in Drosophila, there is a region in the blastoderm of the moth midge Clogmia albipunctata, which lacks canonical gap gene expression. Is a non-canonical gap gene functioning in this area? Here, we characterize tarsal-less (tal) in C. albipunctata. The homolog of tal in the flour beetle Tribolium castaneum (called milles-pattes, mlpt) is a bona fide gap gene. We find that Ca-tal is expressed in the region previously reported as lacking gap gene expression. Using RNA interference, we study the interaction of Ca-tal with gap genes. We show that Ca-tal is regulated by gap genes, but only has a very subtle effect on tailless (Catll), while not affecting other gap genes at all. Moreover, cuticle phenotypes of Ca-tal depleted embryos do not show any gap phenotype. We conclude that Ca-tal is expressed and regulated like a gap gene, but does not function as a gap gene in C. albipunctata.

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Posted February 16, 2018.
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tarsal-less is expressed as a gap gene but has no gap gene phenotype in the moth midge Clogmia albipunctata
Eva Jiménez-Guri, Karl R. Wotton, Johannes Jaeger
bioRxiv 266288; doi: https://doi.org/10.1101/266288
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tarsal-less is expressed as a gap gene but has no gap gene phenotype in the moth midge Clogmia albipunctata
Eva Jiménez-Guri, Karl R. Wotton, Johannes Jaeger
bioRxiv 266288; doi: https://doi.org/10.1101/266288

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