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Myosin1D is an evolutionarily conserved determinant of animal Left/Right asymmetry

Thomas Juan, Charles Géminard, Jean-Baptiste Coutelis, Delphine Cerezo, Sophie Polès, Stéphane Noselli, Maximilian Fürthauer
doi: https://doi.org/10.1101/267146
Thomas Juan
1Université Côte d’Azur, CNRS, Inserm, Institut de Biologie Valrose, Nice, France.
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Charles Géminard
1Université Côte d’Azur, CNRS, Inserm, Institut de Biologie Valrose, Nice, France.
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Jean-Baptiste Coutelis
1Université Côte d’Azur, CNRS, Inserm, Institut de Biologie Valrose, Nice, France.
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Delphine Cerezo
1Université Côte d’Azur, CNRS, Inserm, Institut de Biologie Valrose, Nice, France.
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Sophie Polès
1Université Côte d’Azur, CNRS, Inserm, Institut de Biologie Valrose, Nice, France.
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Stéphane Noselli
1Université Côte d’Azur, CNRS, Inserm, Institut de Biologie Valrose, Nice, France.
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  • For correspondence: noselli@unice.fr furthauer@unice.fr
Maximilian Fürthauer
1Université Côte d’Azur, CNRS, Inserm, Institut de Biologie Valrose, Nice, France.
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  • For correspondence: noselli@unice.fr furthauer@unice.fr
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Abstract

The establishment of Left/Right (LR) asymmetry is fundamental to animal development. While the pathways governing antero-posterior and dorso-ventral patterning are well conserved among different phyla, divergent mechanisms have been implicated in the specification of LR asymmetry in vertebrates and invertebrates. A cilia-driven, directional fluid flow is important for symmetry breaking in numerous vertebrates, including zebrafish1–⇓⇓⇓⇓⇓⇓⇓⇓10. Alternatively, LR asymmetry can be established independently of motile cilia, notably through the intrinsic chirality of the acto-myosin cytoskeleton11–⇓⇓⇓⇓⇓⇓18. Here we show that MyosiniD (Myo1D), which has been previously identified as a key determinant of LR asymmetry in Drosophila12,13, is essential for the formation and the function of the zebrafish LR Organizer (LRO). We show that Myo1D controls the polarity of LRO cilia and interacts functionally with the Planar Cell Polarity (PCP) gene VanGogh-like2 (Vangl2)19, to promote the establishment of a functional LRO flow. Our findings identify Myo1D as the first evolutionarily conserved determinant of LR asymmetry, and show that functional interactions between Myo1D and PCP are central to the establishment of animal LR asymmetry.

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Posted February 16, 2018.
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Myosin1D is an evolutionarily conserved determinant of animal Left/Right asymmetry
Thomas Juan, Charles Géminard, Jean-Baptiste Coutelis, Delphine Cerezo, Sophie Polès, Stéphane Noselli, Maximilian Fürthauer
bioRxiv 267146; doi: https://doi.org/10.1101/267146
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Myosin1D is an evolutionarily conserved determinant of animal Left/Right asymmetry
Thomas Juan, Charles Géminard, Jean-Baptiste Coutelis, Delphine Cerezo, Sophie Polès, Stéphane Noselli, Maximilian Fürthauer
bioRxiv 267146; doi: https://doi.org/10.1101/267146

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