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Incomplete reprogramming of cell-specific epigenetic marks during asexual reproduction leads to heritable phenotypic variation in plants

Anjar Wibowo, View ORCID ProfileClaude Becker, Julius Durr, Jonathan Price, Stijn Spaepen, Sally Hilton, Hadi Putra, Ranjith Papareddy, Quentin Saintain, Sarah Harvey, Gary D. Bending, Paul Schulze-Lefert, View ORCID ProfileDetlef Weigel, View ORCID ProfileJose Gutierrez-Marcos
doi: https://doi.org/10.1101/267955
Anjar Wibowo
1School of Life Sciences, University of Warwick, Coventry CV4 7AL, UK
2Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tübingen, Germany
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Claude Becker
2Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tübingen, Germany
3Gregor Mendel Institute of Molecular Plant Biology, Austrian Academy of Sciences, Vienna Biocenter (VBC), 1030 Vienna, Austria
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  • ORCID record for Claude Becker
Julius Durr
1School of Life Sciences, University of Warwick, Coventry CV4 7AL, UK
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Jonathan Price
1School of Life Sciences, University of Warwick, Coventry CV4 7AL, UK
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Stijn Spaepen
4Department of Plant Microbe Interactions, Max Planck Institute for Plant Breeding Research, Carl-von-Linné-Weg 10, 50829 Köln, Germany. Cluster of Excellence on Plant Sciences (CEPLAS), Max Planck Institute for Plant Breeding Research, 50829 Köln, Germany
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Sally Hilton
1School of Life Sciences, University of Warwick, Coventry CV4 7AL, UK
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Hadi Putra
1School of Life Sciences, University of Warwick, Coventry CV4 7AL, UK
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Ranjith Papareddy
1School of Life Sciences, University of Warwick, Coventry CV4 7AL, UK
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Quentin Saintain
1School of Life Sciences, University of Warwick, Coventry CV4 7AL, UK
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Sarah Harvey
1School of Life Sciences, University of Warwick, Coventry CV4 7AL, UK
5Department of Biology, University of York, York YO10 5DD, UK
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Gary D. Bending
1School of Life Sciences, University of Warwick, Coventry CV4 7AL, UK
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Paul Schulze-Lefert
4Department of Plant Microbe Interactions, Max Planck Institute for Plant Breeding Research, Carl-von-Linné-Weg 10, 50829 Köln, Germany. Cluster of Excellence on Plant Sciences (CEPLAS), Max Planck Institute for Plant Breeding Research, 50829 Köln, Germany
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Detlef Weigel
2Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tübingen, Germany
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  • For correspondence: weigel@tue.mpg.de j.f.gutierrez-marcos@warwick.ac.uk
Jose Gutierrez-Marcos
1School of Life Sciences, University of Warwick, Coventry CV4 7AL, UK
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  • ORCID record for Jose Gutierrez-Marcos
  • For correspondence: weigel@tue.mpg.de j.f.gutierrez-marcos@warwick.ac.uk
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Abstract

Plants differ from animals in their capability to easily regenerate fertile adult individuals from terminally differentiated cells [1]. This unique developmental plasticity is commonly observed in nature where many species can reproduce asexually through the ectopic initiation of organogenic or embryogenic developmental programs [2, 3]. However, it is not currently known if this developmental reprogramming is coupled to a global epigenomic resetting, or what impact it has on the phenotype of the clonal progeny. Here we show that plants asexually propagated via induction of a zygotic developmental program do not fully reset cell-specific epigenetic imprints. These imprints are instead inherited even over multiple rounds of sexual reproduction, becoming fixed in hybrids and resulting in heritable molecular and physiological phenotypes that depend on the founder cell used. Our results demonstrate how novel phenotypic variation in plants can be unlocked through the incomplete reprogramming of cell-specific epigenetic marks during asexual propagation.

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Posted February 19, 2018.
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Incomplete reprogramming of cell-specific epigenetic marks during asexual reproduction leads to heritable phenotypic variation in plants
Anjar Wibowo, Claude Becker, Julius Durr, Jonathan Price, Stijn Spaepen, Sally Hilton, Hadi Putra, Ranjith Papareddy, Quentin Saintain, Sarah Harvey, Gary D. Bending, Paul Schulze-Lefert, Detlef Weigel, Jose Gutierrez-Marcos
bioRxiv 267955; doi: https://doi.org/10.1101/267955
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Incomplete reprogramming of cell-specific epigenetic marks during asexual reproduction leads to heritable phenotypic variation in plants
Anjar Wibowo, Claude Becker, Julius Durr, Jonathan Price, Stijn Spaepen, Sally Hilton, Hadi Putra, Ranjith Papareddy, Quentin Saintain, Sarah Harvey, Gary D. Bending, Paul Schulze-Lefert, Detlef Weigel, Jose Gutierrez-Marcos
bioRxiv 267955; doi: https://doi.org/10.1101/267955

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